CAS: 17630-75-0; 5-Chloro-2-Oxindole

上下游产品

CAS号17630-76-1 5-氯靛红 | CAS号22908-29-8 (5-chloro-2-nit... | CAS号22908-28-7 2-(5-氯-2-硝基苯基)乙酸 | CAS号100487-78-3 5-chloro-3-diaz... | CAS号127792-49-8 2-(2-溴-5-氯苯基)乙腈 | CAS号65816-14-0 1,3-dihydro-1-M... | CAS号106-47-8 对氯苯胺 | CAS号79-04-9 氯乙酰氯 | CAS号100487-33-0 N-benzoyl-5-chl... | CAS号120210-48-2 替尼达普 | CAS号17630-76-1 5-氯靛红 | CAS号113423-48-6 3,3-二溴-5-氯-1,3-... | CAS号73424-95-0 5-氯-1,3-二氢吲哚-2-硫酮 | CAS号91098-13-4 2H-Indol-2-one,...

5-氯靛红置于sodium Ethanolate,一水合肼体系中,用 甲醇,乙醇 用作溶剂,化学反应 6.0H,反应生成5-氯氧化吲哚
参考文献:合成和5-抗肿瘤活性[1-(3-(二甲氨基)丙基)-5-卤代-2-Oxoindolin-(3 ž-亚基甲基)]-2,4-二甲基-1-ħ吡咯-3-甲酰胺
标题:合成和5-抗肿瘤活性[1-(3-(二甲氨基)丙基)-5-卤代-2-Oxoindolin-(3 ž-亚基甲基)]-2,4-二甲基-1-ħ吡咯-3-甲酰胺
摘要:我们在此报告基于已知的多靶点受体酪氨酸激酶抑制剂舒尼替尼和先前发现的化合物tmp-20的结构特征,设计和合成新型1-[3-(二甲基氨基)丙基]吲哚-2-酮衍生物在我们的实验室中具有非常好的抗肿瘤活性.评价了这些新合成的衍生物对五种人类癌细胞系和vegf / Bfgf刺激的huvec的体外活性.结果显示,所有目标化合物1A-P均显示出强大的抗肿瘤活性,化合物1E-H(ic 50值:0.45-5.08μm)比舒尼替尼(ic 50值:1.35-6.61μm)更具活性,并且活性最高的化合物1H(ic50:0.47-3.11μm)对所有五种癌细胞系的效力比舒尼替尼高2.1-4.6倍.另外,与舒尼替尼一样,1A-P对bfgf刺激的huvec以外的vegf刺激的huvec具有更高的选择性.
Doi:10.1016/j.Bmcl.2011.03.031

专利信息

专利号:RU-2035448-C1
优先权日:1992-04-20
标题:2-acetonyl-5,5-dimethyl-1,2,3,4,5,6,7,8-octahydronaphthalene as a component of perfumery composition, method of its synthesis, 2,6-dimethyl-2,6,10-tridecatriene-12-one as an intermediate product in synthesis of 2-acetonyl-5,5-dimethyl-1,2,3,4,5,6,7,8-octahydronaphthalene

专利号:CN-107088437-B
优先权日:2017-05-16
标题 :Catalyst for synthesis of isobornyl acetate and synthesis method of isobornyl acetate

专利号:US-6479696-B1
优先权日:1999-07-05
标题:Method for synthesis and process inhibition of isobornyl (meth)acrylate
发明人：KNEBEL JOACHIM; SAAL DORIS
权利人:ROEHM GMBH
摘要:Isobornyl (meth)acrylate is synthesized by a two-stage one-pot process, wherein isobornyl acetate is converted to isoborneol followed by transesterification with (meth)acrylic acid methyl ester, without isolation of the intermediates or purification of the product.

专利号:WO-0006525-A9
优先权日:1998-07-25
标题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:WO-9948868-A9
优先权日:1998-03-26
标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase
发明人：FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:US-RE29882-E
优先权日:1973-04-27
标题 :Synthesis of oxindoles from anilines and intermediates therein
摘要:Preparing oxindoles and intermediates therefor by reacting an N-haloaniline with β-thio ester or β-thio amides to form an azasulfonium halide, reacting the azasulfonium halide with a base to form an ortho[thio-ether (hydrocarbonoxycarbonyl) alkyl]aniline, or a [thio-ether (aminocarbonyl) alkyl]aniline, reacting the ortho-substituted aniline with an acid to form a 3-thio-ether-2-oxindole, and then reducing the 3-thio-ether-2-oxindole with Raney Nickel to form the 2-oxindole.