CAS: 42926-52-3; 2-Ethoxybenzoyl Chloride

上下游产品

2-ethoxybenzoic acid methyl salicylate 2-ethoxy-benzoic acid benzo[1,3]dioxol-5-yl ester 2-ethoxy-benzoic acid-(1-phenyl-2-pyrrolidino-ethyl ester); hydr°Chloride 2-ethoxy-benzoic acid-(1-phenyl-2-piperidino-ethyl ester); hydr°Chloride 2,5-bis-[4-(2-ethoxy-benzoylamino)-phenyl]-furan

2-乙氧基苯甲酸置于草酰氯体系中,用 二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 2.0H,反应生成 邻乙氧基苯甲酰氯
参考文献:脱羟基甲基环氧喹诺酮类似物作为nf-Kb功能抑制剂的合成及其构效关系.
标题:脱羟基甲基环氧喹诺酮类似物作为nf-Kb功能抑制剂的合成及其构效关系.
摘要:我们先前发现脱羟甲基环氧喹诺酮(dhmeq)抑制nf-Kb活化并在体内表现出抗炎活性.在这里,我们设计并合成了dhmeq的类似物,并测试了它们在人t细胞白血病jurkat细胞中作为nf-Kb抑制剂的生物学活性.发现苯甲酰胺部分的2-位上的羟基对于抑制活性是必需的.但是该组的醚化并未完全降低活性.因此,对于进一步的机理研究,在2-位的羟基对于与接头和生物素部分的延伸可能是有用的.
DOI:10.1016/s0968-0896(02)00315-2

专利信息

专利号:US-5719283-A
优先权日:1990-06-20
标 题:Intermediates useful in the synthesis of pyrazolopyrimidinone antianginal agents
发明人：BELL ANDREW SIMON; BROWN DAVID; TERRETT NICHOLAS KENNETH
权利人:PFIZER
摘要:Compounds of the formula ##STR1## wherein R 1 is H, C 1 -C 3 alkyl, C 3 -C 5 cycloalkyl or C 1 -C 3 perfluoroalkyl; n R 2 is H, C 1 -C 6 alkyl optionally substituted by OH, C 1 -C 3 alkoxy or C 3 -C 6 cycloalkyl, or C 1 -C 3 perfluoroalkyl; n R 3 is H, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, C 3 -C 7 cycloalkyl, C 1 -C 6 perfluoroalkyl or (C 3 -C 6 cycloalkyl)C 1 -C 6 alkyl; n and Y is chloro, bromo, or fluoro. n The above compounds are intermediates useful in the synthesis of certain pyrazolopyrimidinones which inhibit cyclic guanosine 3', 5'-monophosphate phosphodiesterase.

专利号:WO-0119827-A1
优先权日:1999-09-13
标题 :A novel process for the synthesis of sildenafil citrate
发明人：KANKAN RAJENDRA NARAYAN RAO; RAO DHARAMRAJ RAMCHANDRA
权利人:CIPLA LTD; KANKAN RAJENDRA NARAYAN RAO; RAO DHARAMRAJ RAMCHANDRA
摘要:The sildenafil citrate of formula (I) is obtained efficiently and in a cost effective manner by a compound of formula (II) subjecting to methylation where R1 and R2 are H; or R1 is H and R2 is methyl; or R1 is H and R2 is H.

专利号:CN-104804003-A
优先权日:2015-04-27
标题 :Synthesis of 5-aryl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

专利号:CN-103044330-B
优先权日:2013-01-14
标 题:A New Process for the Green Synthesis of Sildenafil Intermediate 4-Amino-1-Methyl-3-n-Propylpyrazole-5-Carboxamide

专利号:CN-103044330-A
优先权日:2013-01-14
标 题:A New Process for the Green Synthesis of Sildenafil Intermediate 4-Amino-1-Methyl-3-n-Propylpyrazole-5-Carboxamide

专利号:CN-101412734-A
优先权日:2007-01-25
标 题 :A kind of phosphorophenanthrene-containing small molecule ester compound (ODOPB-DBC) and its synthesis process