专利号:US-2018371021-A1 优先权日:2017-05-11 标 题 :Peptidomimetic macrocycles and uses thereof 发明人:AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN 权利人:AILERON THERAPEUTICS INC 摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.
专利号:US-7199201-B2 优先权日:2003-12-19 标题:Synthetic polyisoprene rubber 发明人:HALASA ADEL FARHAN; HSU WEN-LIANG; RYBA AARON MICHAEL; ZHOU JIN-PING; JASIUNAS CHAD AARON; SANDSTROM PAUL HARRY 权利人:GOODYEAR TIRE & RUBBER 摘要:The neodymium catalyst system prepared by the technique of this invention can be used in the polymerization of isoprene monomer into synthetic polyisoprene rubber having an extremely high cis-microstructure content and high stereo regularity. This polyisoprene rubber will crystallize under strain and can be compounded into rubber formulations in a manner similar to natural rubber. This invention more specifically discloses a process for the synthesis of polyisoprene rubber which comprises polymerizing isoprene monomer in the presence of a neodymium catalyst system, wherein the neodymium catalyst system is prepared by a process that comprises (1) reacting a neodymium carboxylate with an organoaluminum compound in an organic solvent to produce neodymium-aluminum catalyst component, and (2) subsequently reacting the neodymium-aluminum catalyst component with an elemental halogen to produce the neodymium catalyst system, wherein the neodymium catalyst system is void of nickel-containing compounds.
专利号:US-2014315720-A1 优先权日:2012-10-24 标 题 :Polysaccharide ester microspheres and methods and articles relating thereto 发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY 权利人:CELANESE ACETATE LLC 摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
1: Bayazeid O, Nemutlu E, Eylem CC, İlhan M, Küpeli-Akkol E, Karahan H, Kelicen- Uğur P, Ersoz T, Yalçın FN. Neuroactivity of the naturally occurring aporphine alkaloid, roemerine. Nat Prod Res. 2020 Oct 7:1-6. doi: 10.1080/14786419.2020.1830395. Epub ahead of print. 21(1):45. doi: 10.1186/s40360-020-00416-3. 4: Borowy CS, Mukherji P. Antihistamine Toxicity. 2020 Jun 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. 28(5):466-472. doi: 10.1111/ijpp.12636. Epub 2020 May 10. 2(1):10.1038/s42004-019-0182-8. doi: 10.1038/s42004-019-0182-8. Epub 2019 Jul 19.
合成参考文献
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