CAS: 53112-28-0; Pyrimethanil

该化合物是一种系统杀真菌剂,属于亚利诺匹林类,广泛用于控制葡萄,小麦和蔬菜等作物中的真菌疾病,对Botrytis cinerea 和 Venturia spp.等病原体表现出强烈的预防和治疗活动,主要通过在真菌中抑制甲基硫磷生物合成.主要优势包括它的跨拉尼那运动,确保统一的保护,以及它的雨水使用后耐久性. 青蒿素对非目标生物的毒性较低,有利于环境的持久性,使之适合综合虫害管理方案,当与其他杀真菌类转基因时,其抗药性风险会降低. 化合物的配制成可湿粉或悬浮剂,以产生宽谱效果.

结构式图片

相似化合物

81261-84-9 57356-49-7 198711-26-1

欧盟法规

REACH注册ECHA物质欧盟农药活性物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号420-04-2 氰胺 | CAS号123-54-6 乙酰丙酮 | CAS号80426-58-0 2-anilino-4,6-d... | CAS号74360-10-4 4,6-dimethyl-1-... | CAS号2498-49-9 2-phenylguanidi... | CAS号2002-16-6 苯基胍 | CAS号4472-44-0 2-氯-4,6-二甲基嘧啶 | CAS号42016-93-3 2-氯-4-碘苯胺 | CAS号14001-64-0 4,6-二甲基-2-(甲基硫基)嘧啶

合成工艺路线路线简述

  • 合成目标产物 Pyrimethanil 主要起始原料 Cyanamide And Aniline And Acetylacetone
  • (文献来源)合成步骤主要原料 Cyanamide 和 Aniline 和 Acetylacetone
4,6-二甲基-1-苯基嘧啶-2-硫酮置于镍 Sodium Hydroxide,盐酸羟胺,氢气体系中,用 甲醇,乙醇 作为反应溶剂,化学反应 2.0H,反应生成 嘧霉胺
参考文献:Kashima,Choji; Katoh,Akira; Yokota,Yuko,Chemical And Pharmaceutical Bulletin,1981,Vol. 29,# 9,P. 2516-2519
标题:Kashima,Choji; Katoh,Akira; Yokota,Yuko,Chemical And Pharmaceutical Bulletin,1981,Vol. 29,# 9,P. 2516-2519

专利信息


专利号:US-2023021452-A1
优先权日:2020-03-18
标 题:Modular flow reactors for accelerated synthesis of indium phosphide quantum dots
发明人:ABOLHASANI MILAD; RAMEZANI MAHDI
权利人:UNIV NORTH CAROLINA STATE
摘要:System for synthesis of colloidal nanomaterial includes a multi-stage modular flow reactor that includes four distinct reactor modules for in-flow synthesis of colloidal nanomaterial. The system further includes a computer module for monitor and control of operations of the four reactor modules.

专利号:WO-2022146324-A1
优先权日:2020-12-29
标 题 :Synthesis of pyrimidine-4(lh)-one derivatives from new hydrazineylidene
发明人:SARIPINAR EMIN; BURCU HILAL JANSET; KEKEÇMUHAMMED HÜSEYIN; TAPERA MICHAEL
权利人:T C ERCIYES UENIVERSITESI
摘要:This invention relates to the synthesis of pyrimidine-4 (1H)-one derivatives from Meldrum's acid, carbonyl compounds (aldehyde/ketone), and guanylhydrazone derivatives and tautomers, enantiomers, and salts thereof.

专利号:WO-2025056767-A1
优先权日:2023-09-15
标题 :Process for the preparation of enantiomerically enriched aliphatic amines
发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

专利号:US-2016073631-A1
优先权日:2013-03-04
标 题 :Process for the preparation of dihydropyrrole derivatives
发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:US-9233920-B2
优先权日:2010-06-11
标题 :Process for the preparation of dihydropyrrole derivatives
发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS; SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R 1 and R 2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R 1 and R 2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:US-10906880-B2
优先权日:2016-01-26
标题:Kind of isothiazole oxime ether-containing strobilurin derivatives and its preparation methods and application
发明人:FAN ZHIJIN; CHEN LAI; GUO XIAOFENG; ZHU YUJIE; QIAN XIAOLIN; MA LIUYONG; ZHANG NAILOU; WANG HAIXIA; ZHANG ZHIMING; XU JINGHUA; SONG YINQI
权利人:UNIV NANKAI
摘要:The present invention is that provided a synthesis method of a series of isothiazole oxime ether containing strobilurin derivatives IV. The present invention relates to 3,4-dichloroisothiazolyl oxime ether strobilurin derivatives, and their chemical structural formula is as shown by IV. n n n n n n n n n n The invention discloses the structural formula of the above compound, the synthesis method and the use as an insecticide, a fungicide, an anti-plant virus agent, and an agriculturally acceptable auxiliary or synergist and a commercial insecticide. The use of a fungicide, an anti-plant virus agent and an acaricide in combination for controlling agricultural, forestry, horticultural plant pests, diseases, virus diseases and preparation methods.
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主要参考文献

1. Xu D, Yu G, Xi P, Kong X, Wang Q, Gao L, Jiang Z. Synergistic Effects of Resveratrol and Pyrimethanil against Botrytis cinerea on Grape. Molecules. 2018 Jun 15;23(6):1455. doi: 10.3390/molecules23061455.

合成参考文献


参考文献:10.1016/j.aca.2011.04.058
摘要:Cheng J, Xia Y, Zhou Y, Guo F, Chen G. Application of an ultrasound-assisted surfactant-enhanced emulsification microextraction method for the analysis of diethofencarb and pyrimethanil fungicides in water and fruit juice samples. Anal Chim Acta. 2011 Sep 02;701(1):86–91. doi: 10.1016/j.aca.2011.04.058.
参考文献:10.1002/rcm.5107
摘要:Eikel D, Henion J. Liquid extraction surface analysis (LESA) of food surfaces employing chip-based nano-electrospray mass spectrometry. Rapid Commun Mass Spectrom. 2011 Aug 30;25(16):2345–54. doi: 10.1002/rcm.5107.
参考文献:10.3390/ijerph8062265
摘要:Mnif W, Hassine AI, Bouaziz A, Bartegi A, Thomas O, Roig B. Effect of endocrine disruptor pesticides: a review. Int J Environ Res Public Health. 2011 Jun;8(6):2265–303.
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