CAS: 5315-25-3; 2-Bromo-6-Methylpyridine

相似化合物

79055-52-0 4926-26-5 1211526-18-9

上下游产品

CAS号1824-81-3 2-氨基-6-甲基吡啶 | CAS号18368-63-3 2-氯-6-甲基吡啶 | CAS号626-05-1 2,6-二溴吡啶 | CAS号74-88-4 碘甲烷 | CAS号917-54-4 甲基锂 | CAS号77-78-1 硫酸二甲酯 | CAS号3279-76-3 2-羟基-6-甲基吡啶 | CAS号109-06-8 2-甲基吡啶 | CAS号7789-69-7 五溴化磷 | CAS号10035-10-6 氢溴酸 | CAS号10131-46-1 6-benzyl-2-meth... | CAS号4411-80-7 6,6′-二甲基-2,2′-联吡啶 | CAS号33777-92-3 2,6-bis(6-methy... | CAS号366-18-7 2,2'-联吡啶 | CAS号57154-73-1 6-Methyl-2,2':6... | CAS号56100-22-2 6-甲基-2,2'-联吡啶 | CAS号1762-34-1 5 5'-二甲基-2,2'-联吡啶 | CAS号245678-74-4 5,6'-dimethyl-2... | CAS号1134-35-6 4,4'-二甲基-2,2'-联吡啶

2-氨基-6-甲基吡啶置于氢溴酸,溴,Sodium Nitrite体系中,用 水 作为反应溶剂,以75%的收率获得产物2-溴-6-甲基吡啶
参考文献:6,6'-Dimethyl-2,2'-Bipyridine-4-Ester:一个关键的合成子,用于构建束缚的联吡啶配体
标题:6,6'-Dimethyl-2,2'-Bipyridine-4-Ester:一个关键的合成子,用于构建束缚的联吡啶配体
摘要:我们描述了从容易获得的取代的2-卤代吡啶开始,并基于改良的negishi交叉偶联条件的应用,有效而可扩展地合成4-羰基甲氧基-6,6'-二甲基-2,2'-联吡啶.该化合物是通用的原料,可合成带有卤化物,醇,胺和其他官能团的4-官能化2,2'-联吡啶,适合与生物材料(2A-C,3A-G)结合.通过合成两种双功能镧系螯合剂进一步证明了该化合物在构建更复杂结构中的效用.基于一个2,2'-联吡啶单元的开链配体和基于三个2,2'-联吡啶单元的穴状配体[n 2(bpy)3 Coome].在发光生物标记的领域,报道了相应的eu(iii)隐窝的光物理性质.
DOI:10.1016/j.Tet.2009.06.111

专利信息

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-12247037-B2
优先权日:2018-12-12
标题:1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4h-benzo[f][1,2,4]triazolo[4,3-A][1,4]diazepine derivatives and related compounds as vasopressin antagonists for the treatment of neuro-psychological disorders
发明人：BRANDT GARY
权利人:NEUMORA THERAPEUTICS INC
摘要:The present invention relates to 1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine derivatives and related compounds of Formula (I): wherein A, B, G, R1, R1b, RiC, R2 and X are as defined herein. The present compounds are vasopressin receptor antagonists (in particular of the Via receptor) for the treatment of neuro-psychological disorders, such as e.g. autism, anxiety, stress-related disorders, depression, schizophrenia or bipolar disorder. The present description discloses the synthesis of exemplary compounds, as well as pharmacological data thereof (e.g. pages 71 to 246; examples 1 to 49; tables 1 to 5). An exemplary compound is e.g. 8-chloro-1-(2-(5-fluoropyridin-2-yl)-2,6-diazaspiro[3.3]heptan-6-yl)-5-methyl-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine (example 1, compound no. 1).

专利号:US-8921580-B2
优先权日:2012-05-09
标 题 :Methods and systems for the formation of cyclic carbonates
发明人：HATTON TREVOR ALAN; JAMISON TIMOTHY F; KOZAK JENNIFER AIDEN; SIMEON FRITZ; WU JIE
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Described herein are inventive methods for synthesis of cyclic carbonates from CO 2 and epoxide. In some embodiments, the methods are carried out in the presence of a catalyst comprising an electrophilic halogen. In some embodiments, the methods are carried out in a flow reactor.

专利号:US-8889863-B2
优先权日:2010-07-16
标题:Stereoselective methods, catalysts and intermediates for the synthesis of (−)-Nutlin-3 and related compounds
发明人：JOHNSTON JEFFREY N; DAVIS TYLER A
权利人:JOHNSTON JEFFREY N; DAVIS TYLER A; UNIV VANDERBILT
摘要:The present invention provides methods and intermediates are provided for the preparation of (−)-Nutlin-3. Methods and intermediates are also provided for the enantioselective addition of aryl nitromethanes to aldimines. Bis(amidine) catalysts for the use in these and other reactions are also provided.

专利号:US-2018051042-A1
优先权日:2016-08-22
标题 :Methods for forming saturated (hetero)cyclic borylated hydrocarbons and related compounds
发明人：SMITH III MILTON R; SHANNON TIMOTHY M; MALECZKA JR ROBERT E; FORNWALD RYAN M
权利人:UNIV MICHIGAN STATE
摘要:The disclosure relates to methods for forming at least partially saturated cyclic and heterocyclic borylated hydrocarbons, as well as related compounds, which can be precursor compounds in the synthesis of any of a variety of pharmaceutical or medicinal compounds with a desired structure and/or stereochemistry for drug synthesis or drug candidate evaluation. The methods generally include reduction of an unsaturated cyclic or heterocyclic borylated hydrocarbon having a boron-containing substituent at an sp 2 -carbon, where such reduction converts the sp 2 -carbon to an sp 3 -carbon at the point of attachment of the boron-containing substituent. The methods can exhibit a selectivity for syn-addition during reduction, which can provide stereospecific products, such as when the unsaturated cyclic or heterocyclic reactant is multiply substituted with boron groups and/or other functional groups.

专利号:US-8759509-B2
优先权日:2010-06-10
标题 :Way of using thermolabile groups to protect hydroxyl functions and compounds for implementing the procedure
发明人：CHMIELEWSKI MARCIN KRZYSZTOF
权利人:CHMIELEWSKI MARCIN KRZYSZTOF; INST CHEMII BIOORG POLSKIEJ AKADEMII NAUK
摘要:A procedure for using thermolabile groups to protect a hydroxyl function, above all in nucleosides, nucleotides, oligomers, nucleic acids during the reactions of organic synthesis. Various new compounds that can be used to implement the procedure. The way of using thermolabile groups to protect hydroxyl functions consists in a primary, secondary and tertiary hydroxyl group converting into a groups during the reaction between a compound and a compound whose hydroxyl group is to be blocked. The blocking reaction is carried out by means of widely known methods appropriate for that purpose in the presence of a chemically basic catalyst. The obtained product has its hydroxyl group blocked. Then the compound with the group blocked can be used for the purposes of various chemical processes. After their completion, the hydroxyl group is unblocked by dissolving it in a solvent at a temperature of 50-95° C.