CAS: 683-60-3; Sodium Propan-2-Olate

相似化合物

24363-37-9 88863-33-6 2171-98-4

上下游产品

di-isopropyl ether n-pentylsodium pentane isopropyl alcohol2,2-diphenyl-4-[2]pyridyl-butyronitrile N-isopropylbenzimidazole (4-methoxy-phenyl)-acetic acid-(2-dimethylamino-ethyl ester) butyl isopropyl ether

异丙醇 在 Sodium Hydride体系中,用 二氯甲烷作为反应溶剂,获得 Sodium Isopropylate
参考文献:Nhc-Cdi 甜菜碱加合物及其阳离子衍生物作为二氯甲烷增值的催化剂前体
标题:Nhc-Cdi 甜菜碱加合物及其阳离子衍生物作为二氯甲烷增值的催化剂前体
摘要:N-杂环卡宾和碳二亚胺的两性离子加合物 (Nhc-Cdi) 是一类新兴的有机化合物,具有在各个领域的应用前景.在此,我们报告了 Icycdi( P-Tol ) 甜菜碱加合物 ( 1A ) 及其阳离子衍生物2A和3A作为催化剂前体的用途,通过转化为高附加值产品 Ch 2 Z 2 (Z = Or,Sr或nr 2).该过程意味着二氯甲烷被一系列亲核试剂 Na + Z-(预先形成或原位生成)的选择性氯化物取代从 Hz 和无机碱)以完全选择性地产生甲醛衍生的缩醛,二硫缩醛或缩醛胺.该反应在非常温和的条件下以多克规模进行,使用二氯甲烷作为试剂和溶剂,以及非常低的催化剂负载量 (0.01 Mol%).Ch 2 Z 2衍生物在过滤和蒸发后以定量产率分离,这有利于回收过量的二氯甲烷.合成甲缩醛 Ch 2 (Ome) 2 的机理研究排除了有机催化是 Ch 2转移的原因,并提出了相转移催化机制.此外,我们观察到1A和2A
Doi:10.1021/Acs.J°C.1C01971

专利信息

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:US-2023174567-A1
优先权日:2020-05-22
标题:Synthesis of fluorinated nucleotides
发明人：ARMIGER TRAVIS; BELYK KEVIN M; BENKOVICS TAMAS; CHUNG CHEOL K; JI CHEN YINING; JOHNSON HEATHER CLAIRE; KLAPARS ARTIS; LIU ZHIJIAN; LIU ZHUQING; MOORE JEFFREY C; NEEL ANDREW J; PENG FENG; RUMMELT STEPHAN M; SALEHI MARZUARANI NASTARAN; SHERRY BENJAMIN D; SONG ZHIGUO JAKE; TURNBULL BEN WILLIAM HULME; WANG LU; XU FENG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3′-fluoro-thio-guanosine monophosphate or 3′-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. (I)

专利号:US-2022298136-A1
优先权日:2019-08-21
标题 :Process for synthesis of pyrazolidinone compounds
发明人：MATHUR SUCHET SARAN; JAIN NANDKUMAR JANARDAN; MORE MAHENDRA MAHIPAT
权利人:GHARDA CHEMICALS LTD
摘要:A process for the synthesis of pyrazolidinone, particularly alkyl 2-(3-chloropyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylate (pyrazolidinone) compound, is provided. The process is simple, economical, and produces alkyl 2-(3-chloropyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylate with a comparatively high yields.

专利号:US-2011130591-A1
优先权日:2009-06-03
标 题:Steroselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：FANDRICK DANIEL R; REEVES JONATHAN T; SONG JINHUA J
权利人:BOEHRINGER INGELHEIM INT
摘要:A process for synthesis of a compound of Formula (X) n n n n n n n n n n wherein:n R 1 is an aryl group substituted with one to three substituent groups,n wherein each substituent group of R 1 is independently C 1 -C 5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromethyl,n wherein each substituent group of R 1 is optionally independently substituted with one to three substituents selected from C 1 -C 3 alkyl, C 1 -C 3 alkoxy, phenyl, and alkoxyphenyl; and n n R 2 and R 3 are each independently C 1 -C 5 alkyl.

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人：MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

专利号:WO-2021033165-A1
优先权日:2019-08-21
标 题:Process for synthesis of pyrazolidinone compounds
发明人：MATHUR SUCHET SARAN; MHATRE HRIDAYNATH VISHWANATH; PEDHAVI VISHAL PARSHURAM
权利人:GHARDA CHEMICALS LTD
摘要:The present disclosure relates to a process for the synthesis of pyrazolidinone, particularly alkyl 2-(3-chloropyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylate (pyrazolidinone) compound. The process of the present disclosure is simple, economical, and produces alkyl 2-(3-5 chloropyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylate with a comparatively high yields.