CAS: 69038-74-0; Tert-Butyl 3-Bromobenzoate

上下游产品

间溴苯甲酸 M-Bromobenzoic Acid 585-76-2

间溴苯甲酸,2-(叔-丁氧基)吡啶置于三氟化硼乙醚体系中,用 甲苯 作为反应溶剂,化学反应 0.5H,以92%的收率获得产物3-溴苯甲酸叔丁酯
参考文献:在温和的条件下,使用三氟化硼.二乙醚快速,实用地由2-叔丁氧基吡啶合成叔丁酯
标题:在温和的条件下,使用三氟化硼.二乙醚快速,实用地由2-叔丁氧基吡啶合成叔丁酯
摘要:已经开发了从2-叔丁氧基吡啶实际直接制备叔丁酯的方法.该系统的特点是在甲苯溶剂中使用三氟化硼.乙醚乙醚,可在室温下快速完成反应.使用该反应方案,由几种不同的羧酸以高收率合成了多种叔丁酯.该实用方法为保护具有叔丁基的羧酸提供了一种有前途和有效的方法.
DOI:10.1016/j.Tet.2018.05.050

专利信息

专利号:WO-2023057548-A1
优先权日:2021-10-07
标题:Ccr6 receptor modulators
发明人：AISSAOUI HAMED; ALLEMANN OLIVER; CAROFF EVA; MEYER EMMANUEL; RICHARD-BILDSTEIN SYLVIA
权利人:IDORSIA PHARMACEUTICALS LTD
摘要:The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the prevention or treatment of e.g. inflammatory/autoimmune diseases/disorders and cancer.

专利号:US-11286268-B1
优先权日:2019-07-02
标题:EIF4E-inhibiting compounds and methods
发明人：SPERRY SAMUEL; XIANG ALAN X; ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; SHAGHAFI MIKE; MICHELS THEO; NILEWSKI CHRISTIAN; TRAN CHINH VIET; PACKARD Garrick Kenneth; GRUBBS ALAN; URKALAN KAVERI; MUKAIYAMA TAKASUKE
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , Q, L 1 , L 2 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.