CAS: 78213-16-8; Diethylamine 2-(2-((2,6-Dichlorophenyl)Amino)Phenyl)Acetate

专利信息

专利号:US-9051302-B2
优先权日:2008-01-15
标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
发明人：WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN
权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG
摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

专利号:US-5914322-A
优先权日:1992-02-20
标 题:Treatment of disease and conditions
发明人：FALK RUDOLF EDGAR; ASCULAI SAMUEL SIMON
权利人:HYAL PHARMA CORP
摘要:A topically applied transdermally penetrating systemic independent acting pharmaceutical combination and formulation for the treatment of a disease or condition of the skin and exposed tissue for example, basal cell carcinoma, the precancerous, often recurrent, actinic keratoses lesions, fungal lesions, 'liver' spots and like lesions (found for the most part in the epidermis), squamous cell tumours, metastatic cancer of the breast to the skin, primary and metastatic melanoma in the skin, genital warts (condyloma acuminata) cervical cancer, and HPV (Human Papilloma Virus) including HPV of the cervix, psoriasis (both plaque-type psoriasis and nail bed psoriasis), corns on the feet and hair loss on the head of pregnant women, comprising, together with pharmaceutical excipients suitable for topical application, a therapeutically effective non-toxic amount of a drug which inhibits prostaglandin synthesis administered with, or carried in, an amount of hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments, and/or sub-units of hyaluronic acid (preferably hyaluronic acid and salts thereof) sufficient to facilitate the drug's penetration through the skin and tissue (including any scar tissue) at the site requiring treatment, to block prostaglandin synthesis.

专利号:US-5792753-A
优先权日:1991-07-03
标 题:Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
发明人：FALK RUDOLF EDGAR; ASCULAI SAMUEL SIMON
权利人:HYAL PHARMA CORP
摘要:A topically administrable pharmaceutical composition is disclosed which comprises a therapeutically effective amount of a drug which inhibits prostaglandin synthesis, and an amount of a form of hyaluronic acid sufficient to transport the composition through the skin into the epidermis or dermis where the composition remains until discharged via the lymphatic system, wherein n (a) the drug is 1-5% by weight of the composition, and n (b) the form of hyaluronic acid is 1-3% by weight of the composition, has a molecular weight greater than about 150,000 daltons and less than 750,000 daltons, and is selected from the group consisting of hyaluronic acid and salts thereof.

专利号:US-10239856-B2
优先权日:2008-01-15
标题:Synthesis of resorcylic acid lactones useful as therapeutic agents

专利号:CN-101990399-B
优先权日:2008-01-15
标 题:Synthesis of dihydroxybenzoic acid lactones as therapeutic agents

专利号:US-2011217335-A1
优先权日:2008-01-15
标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents