CAS: 16937-99-8; Boc-D-Leu-Oh

相似化合物

200937-17-3 64727-35-1 103478-62-2

上下游产品

CAS号328-38-1 D-亮氨酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号73371-96-7 2-[[(tert-butox... | CAS号54594-06-8 D-烯丙基甘氨酸 | CAS号170642-24-7 (R)-2-amino-N-(... | CAS号106930-51-2 N-B°C-D-亮氨醇 | CAS号328-38-1 D-亮氨酸 | CAS号89536-84-5 N-(叔丁氧基羰基)-N-甲基... | CAS号106930-51-2 N-B°C-D-亮氨醇 | CAS号116300-00-6 (s)-3-b°C-amino... | CAS号68838-94-8 (R)-2-氨基-4-甲基戊酸苄酯盐酸盐

(S,S)-Pseudoephedrine D-Allylglycinamide 以 1,4-二氧六环,水 用作溶剂,化学反应 10.0H,反应生成Boc-D-亮氨酸
参考文献:合成 D-和l-α-氨基酸,N-保护的 α-氨基酸和 N-甲基-α-氨基酸的高度实用方法
标题:合成 D-和l-α-氨基酸,N-保护的 α-氨基酸和 N-甲基-α-氨基酸的高度实用方法
摘要:提供了一种非常实用的合成 D-和 L-α-氨基酸,N-保护的 α-氨基酸和 N-甲基-α-氨基酸的方法的完整细节,其中使用伪麻黄碱甘氨酰胺的不对称烷基化作为关键步骤(1) 或伪麻黄碱肌酰胺 (2).介绍了分别从伪麻黄碱和甘氨酸甲酯或肌氨酸甲酯合成 1 和 2 的实用程序.描述了 1 和 2 的烯醇化和随后的烷基化的最佳方案.发现 1 和 2 的烷基化反应对于范围广泛的卤代烷底物非常有效,并且产物以高非对映选择性形成.通过在水或水-二恶烷混合物中加热,这些烷基化反应的产物可以有效地水解并且几乎没有外消旋化.该协议为制备高对映体纯度的无盐 α-氨基酸提供了一种非常实用的方法.或者,烷基化产物...
Doi:10.1021/ja9624073

专利信息

专利号:US-11708341-B2
优先权日:2016-08-05
标题:Synthesis of (S)-2-amino-4-methyl-((R)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof
发明人：Beaver Matthew; CUI SHENG; SHI XIANGQING
权利人:AMGEN INC
摘要:The present invention provides new methods for preparing compound 5, and pharmaceutically acceptable salts thereof, of structure n nCompound 5, or a pharmaceutically acceptable salt thereof, is an important intermediate in the synthesis of carfilzomib. The invention further provides methods of making a useful manganese catalyst that may be used in the epoxidation step of the present invention.

专利号:US-2017320908-A1
优先权日:2014-11-19
标题 :Solid phase synthesis of cyclic amino acid molecules
发明人：HICKEY JENNIFER L; MANCUSO JOHN; MARSAULT ERIC; ROUGHTON ANDREW L; TREDER ADAM P; TREMBLEY MARIE-CLAUDE J; YUDIN ANDREI K; ZARETSKY SERGE
权利人:ENCYCLE THERAPEUTICS; GOVERNING COUNCIL OF THE UNIV OF TORONTO; UNIV SHERBROOKE
摘要:The present invention relates to cyclic amino acid molecules and methods of preparing the same, and in particular the macrocyclization of amino acids or linear peptides bound to a solid support.

专利号:US-2018312463-A1
优先权日:2015-10-22
标题:Synthesis of Cyclohexane Carboxamide Derivatives Useful as Sensates in Consumer Products
发明人：YELM KENNETH EDWARD; WOS JOHN AUGUST; BUNKE GREGORY MARK; FREDERICK HEATH; HAUGHT JOHN CHRISTIAN; HOKE STEVEN HAMILTON; SREEKRISHNA KOTI TATACHAR; LIN YAKANG
权利人:PROCTER & GAMBLE
摘要:Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5783577-A
优先权日:1995-09-15
标题 :Synthesis of quinazolinone libraries and derivatives thereof
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:WO-9710221-A1
优先权日:1995-09-15
标 题:Synthesis of quinazolinone libraries
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TORREY PINES INST
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.