CAS: 1761-61-1; 5-Bromo-2-Hydroxybenzaldehyde

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CAS号89-95-2 邻甲基苄醇 | CAS号90-02-8 水杨醛 | CAS号50-00-0 甲醛 | CAS号106-41-2 对溴苯酚 | CAS号82944-17-0 6-bromo-2,2-dim... | CAS号106-49-0 对甲苯胺 | CAS号82486-43-9 Benzaldehyde,5-... | CAS号67-66-3 氯仿 | CAS号1098984-27-0 5-(3-fluoro-4-m... | CAS号1111129-30-6 5-(3,5-dimethyl... | CAS号1111128-77-8 5-(3,4-dimethox... | CAS号111016-52-5 3-(1,3-benzothi... | CAS号106578-01-2 6-bromo-3-(2-br... | CAS号1063714-84-0 5-(3,5-dimethox... | CAS号112359-98-5 4-bromo-6-[(2-p... | CAS号40530-18-5 5-溴-2-羟基苯甲腈 | CAS号428482-55-7 5-Bromo-2-[(4-c... | CAS号38220-77-8 5-溴-2-苯并呋喃甲醇

水杨醛置于四丁基溴化铵,Isoquinolinium Chlorochromate体系中,用 水 用作溶剂,化学反应 7.0H,以60%的收率获得5-溴水杨醛
参考文献:在无酸和无溶剂条件下,在 Peg-600 溶液中使用异喹啉结合的高价铬和四丁基卤化铵对芳香族化合物进行超声辅助卤化
标题:在无酸和无溶剂条件下,在 Peg-600 溶液中使用异喹啉结合的高价铬和四丁基卤化铵对芳香族化合物进行超声辅助卤化
摘要:芳香族化合物的卤化是有机合成中最重要的关键领域之一,因为有机卤化物在温和的条件下可以很容易地转化为其他官能团.此外,有机卤化物还被用作合成救命药物和生物活性分子的重要组成部分[1-9].查阅文献发现,制备芳基卤化物有两种主要的制备途径,即直接卤化法和重氮盐法[1-10].芳香族化合物的直接卤化方法包括通过热或光化学途径使用分子卤素 (X2).Friedel-Crafts 方法也是最古老和有效的卤化方法之一,其中使用路易斯酸作为催化剂.Fecl3,Alcl3 等金属氯化物是这些反应中最常用的金属氯化物 [1,2].然而,已知具有给电子基团的苯酚,苯胺和芳香族化合物在卤素(分子氯或溴)存在下,即使在路易斯酸不存在的情况下,也会发生卤化反应,生成卤化产物 [3].另一方面,溴化混合物(在无酸和无溶剂条件下,在 Peg-600 溶液中使用异喹啉结合的高价铬和四丁基卤化铵对芳香族化合物进行超声波辅助卤化的混合物†
Doi:10.14233/ajchem.2018.21413

专利信息

专利号:US-9790206-B2
优先权日:2013-02-27
标 题:Intermediates for use in the preparation of indazole derivatives and processes for the preparation thereof
发明人：EARY C TODD; HACHE BRUNO P; JUENGST DERRICK; SPENCER STACEY RENEE; STENGEL PETER J; WATSON DANIEL JOHN
权利人:ARRAY BIOPHARMA INC
摘要:Provided herein are novel processes for preparing a compound of Formula (I) to the use of said compound as an intermediate in novel processes for the synthesis of indazole derivatives, and to indazole intermediates and derivatives prepared by the processes described herein.

专利号:US-2005250765-A1
优先权日:2000-08-16
标题 :Diazepinones as antiviral agents
发明人：CHO HIDETSURA; GOGLIOTTI ROCCO D; HAMILTON HARRIET W; KRASUTSKY ALEXEI; NAKAMURA TAKESHI; TADA HIROKI; WEBER PETER C
权利人:CHO HIDETSURA; GOGLIOTTI ROCCO D; HAMILTON HARRIET W; KRASUTSKY ALEXEI; NAKAMURA TAKESHI; TADA HIROKI; WEBER PETER C
摘要:The invention is novel compounds of formula n nwhich exhibit an improved therapeutic index and improved metabolic stability which are useful in the treatment and/or prevention of herpes viral infections. Novel intermediates useful in the synthesis of the final compounds are also part of the invention.

专利号:CN-112074510-A
优先权日:2018-02-27
标 题:Industrial scale synthesis of urolithin A

专利号:CN-106631702-A
优先权日:2016-11-11
标 题 :Catalytic asymmetric synthesis of chiral spirocyclic diphenol derivatives

专利号:WO-2018115362-A1
优先权日:2016-12-22
标 题 :Process for preparing 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzonitrile (crisaborole)
发明人：HUGUET CLOTET JUAN; OZORES VITURRO LÃ?DIA; RODRÃ?GUEZ ROPERO SERGIO; DALMASES BARJOAN PERE
权利人:LABORATORIOS LESVI SL
摘要:The present invention relates to a new one-pot synthesis employing 4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile (compound B) for preparing (4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzonitrile (crisaborole) and pharmaceutically acceptable salts thereof in high yield and high purity. The novel process of the present invention is particularly suitable for industrial scale manufacture of crisaborole and its salts with excellent purity and good yields. The present invention also describes an intermediate, 4-(3-formyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)benzonitrile (compound I), which is inter alia suitable for preparing (4-[(1-hydroxy-1,3-dihydro-2, 1-benzoxaborol-5-yl)oxy]benzonitrile (crisaborole) and pharmaceutically acceptable salts thereof, as well as a another process suitable for industrial scale applications, employing the intermediate compound I in the preparation of crisaborole and pharmaceutically acceptable salts thereof, in high yield and high purity.

专利号:CN-119331000-A
优先权日:2024-10-29
标题 :Keli boron Synthesis method of roxburgh