CAS: 1899-93-0; M-Toluenesulfonyl Chloride

该化合物是一种配有化学配方C7H7ClO2S的芳烃基磺酸氯,其特征为:在元体位置上,用硫化物组群替代的甲苯环,该化合物的外观无色可粉黄,以其浓烈的气味闻名;反应性很强,特别是核糖核,使它成为有机合成中有价值的试剂,特别是用于制备磺酰胺和其他磺酰衍生物.-m-Tolenes ulphonylkenkenkenkyc在二氯甲烷和乙醚等有机溶剂中是溶解的,但水中不溶解.必须小心处理这一化合物,因为它可能会对皮肤,眼睛和呼吸系统造成严重刺激.适当的安全防范措施,包括使用个人防护设备,并在经过良好通风的地区或烟雾头,在与该化学品合作时至关重要.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号108-44-1 3-甲基苯胺 | CAS号28987-79-3 间甲苯基溴化镁 | CAS号6399-00-4 S-(3-methylphen... | CAS号3728-44-7 trimethyl-(3-me... | CAS号937-01-9 m-Tolyltrimethy... | CAS号68971-88-0 TRIBUTYL(3-METH... | CAS号108-40-7 3-甲基苯硫酚 | CAS号617-97-0 3-甲基苯磺酸 | CAS号591-17-3 3-溴甲苯 | CAS号43114-43-8 3-甲砜基苯甲醛 | CAS号2548-44-9 3-(Phenylsulfon... | CAS号1899-94-1 间甲苯磺胺 | CAS号636-76-0 间羧基苯磺酰胺 | CAS号108-40-7 3-甲基苯硫酚 | CAS号148583-69-1 3-(溴甲基)苯磺酰氯 | CAS号14625-58-2 2-(3-methylphen... | CAS号82125-40-4 N,N,3-三甲基-苯磺酰胺 | CAS号885950-34-5 2,3,4,5,6-PENTA... | CAS号10355-06-3 1-甲基-3-(甲基磺酰基)苯

合成工艺路线路线简述

    三甲基(3-甲基苯基)锡烷置于磺酰氯体系中,化学反应 4.0H,反应生成间甲苯磺酰氯
    参考文献:Lube,Andreas; Neumann,Wilhelm P.; Niestroj,Michael,Chemische Berichte,1995,Vol. 128,# 12,P. 1195-1198
    标题:Lube,Andreas; Neumann,Wilhelm P.; Niestroj,Michael,Chemische Berichte,1995,Vol. 128,# 12,P. 1195-1198

    海关参考信息

    专利信息


    专利号:EP-4026837-A1
    优先权日:2021-01-08
    标 题:Process for producing 2,5-diamino-2,5-dideoxy-1,4:3,6-dianhydrohexitol
    发明人:RUIJING GUO; PIRES RAUL; BEUCK SASKIA; LATORRE MARTINEZ IRENE CRISTINA; PAN XIANGCHENG; WANG QIANYI; YANG SHICHENG; JIANG YUAN
    权利人:COVESTRO DEUTSCHLAND AG
    摘要:The invention relates to a process for the synthesis of chiral diamines based on renewable resources. More specifically the invention provides a process for synthesis of diaminoisoidide, diaminoisosorbide, and diaminoisomannide, more specifically 2,5-diamino-2,5-dideoxy-1,4:3,6-dianhydrohexitols.

    专利号:US-2023192718-A1
    优先权日:2018-03-30
    标 题 :Bicyclic enone carboxylates as modulators of transporters and uses thereof
    发明人:SANDANAYAKA VINCENT
    权利人:NIROGY THERAPEUTICS INC
    摘要:The invention generally relates to the field of monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate enone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.

    专利号:US-6479668-B1
    优先权日:1998-09-08
    标 题 :Method of producing pyrrolidine derivatives
    发明人:MURAOKA HIDEO; SATO HARUYO
    权利人:TORAY INDUSTRIES
    摘要:A method for producing pyrrolidine derivatives such as 3,4-epoxypyrrolodines, 3-pyrrolidols and the like, by oxidizing 3-pyrrolines with at least one peroxide in the presence of at least one acid is disclosed. The 3-pyrrolines are produced by deriving cis-2-butene compounds from cis-2-butene-1,4-diols and performing a cyclization between the cis-2-butene derivatives and at least one primary amine. The method may be performed as a one-pot synthesis and may be performed as a continuous reaction.

    专利号:EP-3515880-B1
    优先权日:2017-03-17
    标题:Methods and compositions for synthesis of encoded libraries
    发明人:LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
    权利人:HITGEN INC

    专利号:US-2020149034-A1
    优先权日:2017-03-17
    标题:Methods and Compositions for Synthesis of Encoded Libraries

    专利号:US-8034908-B2
    优先权日:2003-02-14
    标 题:Glycolipids and synthetic method thereof as well as their synthetic intermediates, and synthetic method thereof
    发明人:ANNOURA HIROKAZU; MURATA KENJI; YAMAMURA TAKASHI
    权利人:JAPAN GOVERNMENT
    摘要:Novel glycolipid derivatives, where the substituent of the sphingosine base part is a short carbon chain alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group and efficient synthetic methods for practical mass production of the same and intermediates useful for the synthesis of these compounds. n Glycolipids having the formula (I): n nwhere R 3 indicates a substituted or unsubstituted C 1 to C 7 linear alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group, or substituted or unsubstituted aralkyl group and R 8 indicates a substituted or unsubstituted C 1 to C 35 alkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group are chemically synthesized.
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    主要参考文献

    参考标题:The Organocatalytic Synthesis Of Perfluorophenylsulfides Via The Thiolation Of Trimethyl(Perfluorophenyl)Silanes And Thiosulfonates
    作者:Jinyun Luo,Muze Lin,Leifang Wu,Zhihua Cai,Lin He,Guangfen Du
    摘要:The Organic Superbase T-Bu-P4-Catalyzed Direct Thiolation Of Trimethyl(Perfluorophenyl)Silanes And Thiosulfonates Was Developed. Yields Of Perfluorophenylsulfides Of Up To 97% Under Catalysis Of 5 Mol% T-Bu-P4 Were Achieved. This Method Was Shown To Provide An Efficient Way To Construct The Perfluorophenyl-Sulfur Bond Under Mild Metal-Free Reaction Conditions.

    合成参考文献


    摘要:Kawęcki, R., Science of Synthesis Knowledge Updates, (2018) 4, 284.
    摘要:Kashemirov, B. A.; Błażewska, K.; Justyna, K.; Lyu, J.; McKenna, C. E., Science of Synthesis Knowledge Updates, (2021) 1, 414.
    摘要:Inamoto, K., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 432.
    摘要:Das, A.; Sarmah, B. K., Science of Synthesis: Knowledge Updates, (2024) 1, 339.
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