CAS: 2679-14-3; 3-(Methylamino)Propanoic Acid

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CAS号590-92-1 3-溴丙酸 | CAS号74-89-5 氨基甲烷 | CAS号693-05-0 3-甲氨基丙腈 | CAS号107-94-8 3-氯丙酸 | CAS号24549-12-0 3-(甲基氨基)丙酸甲酯 | CAS号50-00-0 甲醛 | CAS号107-95-9 β-丙氨酸 | CAS号2679-13-2 2-Azetidinone,1... | CAS号141-76-4 3-碘丙酸 | CAS号7732-18-5 水 | CAS号2679-13-2 2-Azetidinone,1... | CAS号124072-61-3 3-[(叔丁氧羰基)(甲基)氨基]丙酸 | CAS号2213-08-3 3-(甲氨基)丙酸乙酯

1-甲基氮杂环丁-2-酮置于sodium Hydroxide体系中,化学反应生成3-甲氨基丙酸
参考文献:β-Sultams 水解的反应性和机理
标题:β-Sultams 水解的反应性和机理
摘要:-与相应的无环磺酰胺的酸和碱催化水解相比,Sultams 的速率分别提高了 109 倍和 107 倍.它们的反应性比类似的-内酰胺高约 103 倍.一些 Sultams 的碱性水解显示出一个速率项,它是氢氧根离子浓度的二级,这表明涉及三角双锥中间体 (Tbpi) 的逐步机制.N-芳基-舒坦的碱性水解的brnsted Lg 值为-0.58,动力学溶剂同位素效应i 为0.60,与tbpi 的限速形成相容.相反,N-烷基--Sultams 的 / 为 1.55,表明 Tbpi 的限速分解.磺酰基的吸电子基团强烈阻碍了-Sultams 的酸催化水解,并提出该机制可能涉及单分子开环以产生磺酰离子.N-苄基-舒坦的酸催化水解的brnsted Lg值为0.32.羧酸对 N-苄基-舒坦的一般酸催化水解显示 0.67 的 Brnsted 值,这归因于特定的酸亲核机制,形成混合酸酐中间体.
Doi:10.1021/ja994293B

专利信息

专利号:US-8178712-B2
优先权日:2006-06-23
标 题:Process for the synthesis of Ibandronate sodium
发明人：RAO DHARAMARAJ RAMCHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI GANPATI
权利人:RAO DHARAMARAJ RAMCHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI GANPATI; CIPLA LTD
摘要:The present invention relates to an improved process for the synthesis of Ibandronate sodium of formula (I). The present invention also provides novel processes for the synthesis of 3-[N-(methylpentyl)amino]propionic acid (III).

专利号:US-10981922-B2
优先权日:2012-04-26
标题 :Synthesis of lactams
发明人：TAVARES FRANCIS XAVIER
权利人:TAVARES FRANCIS XAVIER
摘要:Methods for the synthesis of lactams are presented whereby a carboxylic acid of the formula HOOC—OR—NH-LG, wherein OR is an organic moiety and LG is a leaving group, is reacted with an acid, such as an organic acid, in particular a strong acid, and a dehydrating agent, which may be one in the same such as a strong acid anhydride, such that the amount of acid added allows for the desired transformation to take place without the loss of the leaving group (LG) before the cyclization, and recovering the lactam.

专利号:US-2016257688-A1
优先权日:2013-10-24
标 题 :Process for Synthesis of Lactams
发明人：TAVARES FRANCIS XAVIER
权利人:TAVARES FRANCIS XAVIER
摘要:Methods for the synthesis of lactams are presented whereby a carboxylic acid of the formula HOOC—OR—NH-LG, wherein OR is an organic moiety and LG is a leaving group, is reacted with an acid, such as an organic acid, in particular a strong acid, and a dehydrating agent, which may be one in the same such as a strong acid anhydride, such that the amount of acid added allows for the desired transformation to take place without the loss of the leaving group (LG) before the cyclization, and recovering the lactam such as that of the formula (a), provided herein, wherein G represents the atom(s) needed to form a closed ring.

专利号:WO-0134571-A1
优先权日:1999-11-09
标题:β-AMINOACID COMPOUNDS USEFUL FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS
发明人：AUDIA JAMES EDMUND; PORTER WARREN JAYE; SCOTT WILLIAM LEONARD; STACK DOUGLAS RICHARD; THOMPSON RICHARD CRAIG
权利人:LILLY CO ELI; AUDIA JAMES EDMUND; PORTER WARREN JAYE; SCOTT WILLIAM LEONARD; STACK DOUGLAS RICHARD; THOMPSON RICHARD CRAIG
摘要:The present invention relates β-aminoacid containing compounds of formula (I) which inhibit β-amyloid peptide release and/or its synthesis and are useful in treating Alzheimer's disease and cognition enhancement.

专利号:US-2015087831-A1
优先权日:2012-04-26
标题:Synthesis of lactams

专利号:JP-2021504505-A
优先权日:2017-11-27
标 题:Methods for the synthesis of cyclodextrin derivatives