四氢萘酚置于chromium(Vi) Oxide,硫酸,乙酸酐,溶剂黄146体系中,化学反应生成5-羟基-1-四氢萘酮 参考文献:Organic Analysis. Vii. New Fluorescence Reaction Of Hexose By 5-Hydroxytetralone 标题:Organic Analysis. Vii. New Fluorescence Reaction Of Hexose By 5-Hydroxytetralone 摘要:在硫酸中加热5-羟基四氢萘酮-(1)与含有己糖单位的己糖,低聚糖或多糖时,能够产生绿色荧光.该反应对己糖具有灵敏且特异的检测能力,仅受少数物质干扰.文中列出了己糖,低聚糖和多糖的检测限度,并描述了该试剂的新合成方法. Doi:10.1248/cpb1953.4.209
专利号:WO-2008010578-A1 优先权日:2006-07-21 标题 :Process for production of styrene derivative 发明人:KUWABE SHIN-ITSU; MASAOKA HIDEO; GISELBRECHT KARL-HEINZ; HIEBL JOHANN; REITER KLAUS; SKRANC WOLFGANG; DE VRIES ANDRE HENDRIKUS MARIA; DE VRIES JOHANNES GERARDUS 权利人:ONO PHARMACEUTICAL CO; KUWABE SHIN-ITSU; MASAOKA HIDEO; GISELBRECHT KARL-HEINZ; HIEBL JOHANN; REITER KLAUS; SKRANC WOLFGANG; DE VRIES ANDRE HENDRIKUS MARIA; DE VRIES JOHANNES GERARDUS 摘要:A process for producing a styrene derivative represented by the general formula (III), particularly 5-(3-ethoxy- 3-oxopropyl)-7,8-dihydronaphthalen-1-yl pivalate with efficiency, comprising conducting a coupling reaction of a compound represented by the general formula (I) with a compound represented by the general formula (II) in a non-aqueous solvent in the presence of a catalytic amount of a phosphine complex of nickel or palladium, particularly a phosphine complex of nickel. The styrene derivative is useful as an intermediate for the synthesis of various pharmaceutical agents. (I)(II) (III) wherein each symbol is as defined in the description.
专利号:US-5426227-A 优先权日:1993-06-24 标 题:Enantioselective process for the preparation of leveobunolol 发明人:STAMPA DIEZ DEL CORRAL ALBERTO; CAMPS GARCIA PELAYO; ONRUBIA MIGUEL MARIA DEL CARME; ARNALOT AGUILAR CARMEN 权利人:MEDICHAM S A 摘要:The invention relates to a new, industrially advantageous, process for the preparation of the known beta-adrenergic blocking agent, levobunolol, not requiring resolution of racemic bunolol, based on the enantioselective synthesis of an oxiranic intermediate which is then reacted with tert-butylamine. It consists of reacting 5-hydroxy-3,4-dihydro-1(2H)-naphthalenone with (R)-(-)epichlorhydrine in an aprotic solvent, in the presence of a strong base at a temperature of over 90° C., thus obtaining the intermediate chiral oxirane (S)-5-(2,3-epoxypropoxy)-3,4-dihydro-1-(2H)-naphthalenone with more than 95% optical purity, and then, the intermediate chiral oxirane is reacted with tert-butylamine.
专利号:US-7361789-B1 优先权日:2004-07-28 标 题 :Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis 发明人:YAN QI; ORIHUELA CARLOS; SHEN BO; CHEN YING; WANG XIN; NG JOHN; JI RUIZHI; ZHOU PENGZU 权利人:AMGEN INC 摘要:The present invention relates to novel dihydronaphthalene compounds, compositions, methods for using the same, and processes for preparing the same. The present invention also relates to novel total synthesis approaches for preparing these compounds. In addition, the present invention relates to methods of producing quantities of isomers of these compounds and separating and purifying them using chiral separation techniques. The present invention also relates to methods of producing quantities of a single isometric compound without the need for chiral separation techniques.
专利号:US-5504104-A 优先权日:1993-11-19 标 题:Tricyclic pyrone derivatives as protease inhibitors and antiviral agents 发明人:ELLSWORTH EDMUND L; TAIT BRADLEY D 权利人:WARNER LAMBERT CO 摘要:The present invention relates to novel substituted tricyclic pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The tricyclic pyrone derivatives are useful in the development of therapies for the treatment of vital infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized tricyclic pyrones and of related structures.
专利号:CN-104276934-A 优先权日:2014-09-26 标题:The chemical synthesis method of 4,8-dihydroxy-1-tetralone
参考标题:Efficient Synthesis Of Substances Related To Cinacalcet Hydrochloride Via Heck Coupling 作者:Fan Lei,Boyi Qu,Xiaolong Li,Li Guo,Mei Guan,Li Hai,Hui Jin,Yong Wu |发布日期:2014.10.2 摘要:Abstract Efficient Synthetic Methods To Process Substances Related To Cinacalcet Hydrochloride 1, Generated During The Preparation, Were Described. The Compounds Were Identified As [1-(7,8-Dihydro-Naphthalen-1-Yl)-Ethyl]-[3-(3-Trifluoromethyl-Phenyl)-Propyl]-Amine Hydrochloride 2,[1-(5,6,7,8-Tetrahydro-Naphthalen-1-Yl)-Ethyl]-[3-(3-Trifluoromethyl-Phenyl)-Propyl]-Amine Hydrochloride 3 And [1-(Naph
合成参考文献
参考文献:10.1371/journal.pone.0021922 摘要:Hunt PR, Son TG, Wilson MA, Yu Q, Wood WH, Zhang Y, Becker KG, Greig NH, Mattson MP, Camandola S, Wolkow CA. Extension of Lifespan in C. elegans by Naphthoquinones That Act through Stress Hormesis Mechanisms. PLoS ONE. 2011 Jul 13;6(7):e21922. doi: 10.1371/journal.pone.0021922.