CAS: 35146-32-8; H-His(Trt)-Oh

相似化合物

199119-46-5 109425-51-6 123333-71-1

上下游产品

CAS号109425-51-6 N-Fm°C-N'-三苯甲基-L-组氨酸 | CAS号71-00-1 L-组氨酸 | CAS号74853-62-6 TRT-HIS(TRT)-OH | CAS号32946-53-5 Nim-trityl-L-hi... | CAS号76-83-5 三苯基氯甲烷 | CAS号75-78-5 二甲基二氯硅烷 | CAS号75-77-4 三甲基氯硅烷 | CAS号32926-43-5 N-B°C-N'-三苯甲基-L-组氨酸 | CAS号71-00-1 L-组氨酸 | CAS号109425-51-6 N-Fm°C-N'-三苯甲基-L-组氨酸

N-Fmoc-N'-三苯甲基-L-组氨酸置于sodium Azide体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,以0.483 G的收率获得产物n'-(三苯甲基)-L-组氨酸
参考文献:侧链光活化辅助介导的天然化学肽连接
标题:侧链光活化辅助介导的天然化学肽连接
摘要:光活化连接辅助剂为扩大天然化学连接(ncl)的适用性提供了一种有吸引力的方法.与基于硫醇的巯基苄基型连接支架相比,可光活化的辅助物在连接后通过光解作用被裂解,从而简化了非半胱氨酸ncl中的蛋白质组装并对天然多肽链造成最小的干扰.本研究报告了在n的内部天冬氨酸/谷氨酸侧链上易于连接的 1-[5-(硫甲基)-2-硝基苯基]乙基-(Tmnpe)-辅助基团.-末端肽片段.该助剂可实现长范围 Ncl,并允许在水性缓冲液中进行光解去除,无需试剂.人类程序性细胞死亡配体 1 (Hpd-L1) 肽抑制剂 Ar5Y-3 的合成凸显了该方法的多功能性.tmnpe 基团易于引入,与肽连接反应兼容,并且裂解条件温和,这可能有利于除半胱氨酸连接位点之外的肽或蛋白质合成.
DOI:10.1016/j.Tet.2023.133554

专利信息

专利号:WO-2025136369-A1
优先权日:2023-12-19
标 题 :Safety-catch linkers for solid phase peptide synthesis
发明人：ALBERICIO PALOMERA FERNANDO; NOKI SIKABWE; DE LA TORRE BEATRIZ GARCIA; SANEII HOSSAIN
权利人:AAPPTEC LLC
摘要:A safety-catch linker for solid phase peptide synthesis (SPPS) is provided, having a chemical structure according to Formula I: Formula I, wherein R1 and R2 are each independently selected from hydrogen and methyl; R3 is absent or phenyl; and n is 0 or 1. Also provided are methods of synthesizing the linker, methods of solid phase peptide synthesis (SPPS) of a target peptide employing the resin-bound linker, and kits for SPPS.

专利号:US-2025197441-A1
优先权日:2023-12-19
标题 :Safety-Catch Linkers for Solid Phase Peptide Synthesis
发明人：ALBERICIO PALOMERA FERNANDO; DE LA TORRE BEATRIZ GARCIA; NOKI SIKABWE; SANEII HOSSAIN
权利人:AAPPTEC LLC
摘要:A safety-catch linker for solid phase peptide synthesis (SPPS) is provided, having a chemical structure according to Formula I:wherein R1 and R2 are each independently selected from hydrogen and methyl; R3 is absent or phenyl; and n is 0 or 1. Also provided are methods of synthesizing the linker, methods of solid phase peptide synthesis (SPPS) of a target peptide employing the resin-bound linker, and kits for SPPS.

专利号:US-2025066393-A1
优先权日:2021-12-24
标题 :Amine-protecting group
发明人：XU PENGYU; YONEYAMA SHIN
权利人:SYNCREST INC
摘要:An object of the present invention is to provide novel amine-protecting groups useful for the synthesis of special amino acids. Provided is an amine-protecting group.

专利号:CN-118909049-A
优先权日:2024-08-15
标 题:Synthesis of modified cyclic peptide Triazole-Tiger17 from sea frog skin

专利号:US-RE49961-E
优先权日:2016-10-21
标 题:Solid phase peptide syntheses
发明人：COLLINS JONATHAN M
权利人:CEM CORP
摘要:An improved method of deprotection in solid phase peptide synthesis is disclosed. In particular the deprotecting composition is added in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated acid from the preceding coupling cycle, and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle. Thereafter, the ambient pressure in the vessel is reduced with a vacuum pull to remove the deprotecting composition without any draining step and without otherwise adversely affecting the remaining materials in the vessel or causing problems in subsequent steps in the SPPS cycle.

专利号:US-2024124517-A1
优先权日:2020-12-25
标题:Method for producing peptide compound containing n-substituted-amino acid residue
发明人：MORITA YUYA; NOMURA KENICHI
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:An object of the present invention is to provide a method for efficiently producing a high-purity peptide compound with a high yield. It has been found that the object can be achieved by supporting a peptide on a solid phase synthesis resin prior to a first elongation reaction in a solid phase process.