CAS: 362-75-4; 2',3'-O-Isopropylideneadenosine

相似化合物

19234-66-3 24639-06-3 21950-36-7

上下游产品

CAS号77-76-9 2,2-二甲氧基丙烷 | CAS号58-61-7 腺苷 | CAS号67-64-1 丙酮 | CAS号29706-75-0 Adenosine,N-[(d... | CAS号4744-10-9 丙醛缩二甲醇 | CAS号5605-63-0 2',3'-O-ISOPROP... | CAS号350498-61-2 5'-(anthraquino... | CAS号15888-38-7 ((3aR,4R,6R,6aR... | CAS号35920-39-9 5'-N-乙基酰胺基腺苷 | CAS号4099-81-4 5'-碘-5'-脱氧腺苷 | CAS号19234-66-3 2′,3′-异亚丙基腺苷-5′-羧酸 | CAS号58-61-7 腺苷 | CAS号5536-17-4 阿糖腺苷 | CAS号958-09-8 2'-脱氧腺苷 | CAS号524-69-6 9-pentofuranosy... | CAS号61-19-8 腺苷酸 | CAS号27963-79-7 Adenosine,7,8-d... | CAS号25030-31-3 Adenosine, 5'-s...

2',3'-O-Isopropylidene-6N-Dimethylaminomethylene Adenosine置于palladium Dihydroxide 氢气体系中,用 甲醇,水 用作溶剂,20.0 °C,482.63 Kpa 条件下,反应 14.0H,以98%的收率获得2',3'-异丙叉腺苷
参考文献:甲am的水解和氢解:N,N-二甲基和n,N-二苄基甲form作为伯胺的保护基.
标题:甲am的水解和氢解:N,N-二甲基和n,N-二苄基甲form作为伯胺的保护基.
摘要:
Doi:10.1021/jo980099G

专利信息

专利号:WO-2020128469-A1
优先权日:2018-12-19
标 题 :Synthesis of 8-chloroadenosine derivatives including nuc-9701
发明人：GARLAPATI RAMESH; KOTALA MANI BUSHAN; EVANS JAMES; KENNOVIN GORDON
权利人:NuCana plc
摘要:The present invention generally relates to a novel process for the preparation of 8-chloroadenosine derivatives, and particularly NUC-9701(8-chloroadenosine-5'-O- [naphthyl(benzyloxy-L-alaninyl)] phosphate) an anticancer ProTide of 8-chloroadenosine.

专利号:US-9738679-B2
优先权日:2013-03-15
标 题:Methods of synthesizing substituted purine compounds
发明人：OLHAVA EDWARD JAMES
权利人:EPIZYME INC
摘要:The present invention provides an efficient process for the synthesis of (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol and hydrates thereof and methods for treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also provides novel crystalline forms of (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol and hydrates thereof (Form A, Form B, and Form C), characterized by a unique X-ray diffraction pattern and Differential Scanning calorimetry profile, as well as a unique crystalline structure.

专利号:WO-2022189846-A1
优先权日:2021-03-10
标 题:NOVEL ADENOSYLMERCAPTANE DERIVATIVES AS VIRAL mRNA CAP METHYLTRANSFERASE INHIBITORS
发明人：BOBILEVA OLGA; BOBROVS RAITIS; KANEPE IVETA; KALNINS GINTS; SISOVS MIHAILS; BULA ANNA LINA; JIRGENSONS AIGARS; TARS KASPARS; JAUDZEMS KRISTAPS
权利人:LATVIAN INST ORGANIC SYNTHESIS
摘要:The present invention relates to medicine, and in particular to the treatment of viral infections, more particularly to inhibitors of viral mRNA cap methyltransf erases (MTases). Even more particularly, the invention relates to adenosylmercaptane derivatives and pharmaceutical compositions thereof and their use as inhibitors for viral mRNA cap methyltransferases.

专利号:US-2004181078-A1
优先权日:1997-10-10
标 题 :Tetraphosphonate bicyclic trisanhydrides
发明人：PANKIEWICZ KRZYSZTOF W; LESIAK KRYSTYNA; WATANABE KYOICHI A
权利人:PHARMASSET LTD
摘要:Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates.

专利号:US-7371852-B2
优先权日:2003-01-22
标 题 :Alkyl-linked nucleotide compositions
发明人：HARDEMAN KLASS P; HALL STEVEN E; WARE ROY W; HINKLEY LINDSAY A; JENKS MATTHEW G
权利人:SERENEX INC
摘要:Alkyl-linked nucleotide non-homogeneous solid supports and nucleotide affinity media comprising an alkyl-linked nucleotide are provided. The linker is generally a hydrophobic linker that can be a 3, 4, 5, 6, 7, 8, 9, 10, or a longer carbon chain. Also included in the invention are methods for synthesis of an alkyl-linked nucleotide, nucleotide affinity media and methods of use thereof for affinity chromatography and screening methods.

专利号:US-6713623-B2
优先权日:1996-10-09
标 题:Tetraphosphonate bicyclic trisanhydrides
发明人：PANKIEWICZ KRZYSZTOF W; LESIAK KRYSTYNA; WATANABE KYOICHI A
权利人:PHARMASSET LTD
摘要:Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates.