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专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-2003181713-A1
优先权日:2002-03-04
标 题:Processes for the synthesis of chloroadenosine and methylthioadenosine
发明人：SRIRANGAM JAYARAM KASTURI; SAENZ JAMES EDWARD
摘要:An in situ process for preparing chloroadenosine is described, wherein adenosine in a non-aqueous solvent is reacted with a thionyl chloride and a pyridine to form a reaction solution; the non-aqueous solvent is exchanged with a lower alcohol, and a base is added to the reaction solution; and the resulting chloroadenosine is filtered, washed and dried. Additionally, a two-step process for the synthesis of methylthioadenosine using the chloroadenosine prepared in situ is described.

专利号:US-6306179-B1
优先权日:1997-10-22
标题:Method for the synthesis of 2-hydroxyalkyl-para-phenylenediamines, new 2-hydroxyalkyl-para-phenylenediamines, their use for oxidation dyeing, dyeing compositions and methods of dyeing
发明人：GENET ALAIN; LAGRANGE ALAIN
权利人:OREAL
摘要:The present invention relates to a new method for the synthesis of 2-hydroxyalkyl-para-phenylenediamines which are substituted or unsubstituted at the 5-position of the benzene ring, new 2-hydroxyalkyl-para-phenylenediamines which are substituted or unsubstituted at the 5-position of the benzene ring, their use for the oxidation dyeing of keratinous fibers, the dyeing compositions containing them, as well as the methods of dyeing using them.

专利号:US-12157751-B2
优先权日:2021-05-12
标题 :Process for the synthesis of oligomeric siloxane having sulfone moiety, and silicon-containing compounds having sulfone moiety
发明人：SINGHAL PRAVEEN KUMAR; TARAFDAR GOURAV; RAMESH APEKSHA
权利人:MOMENTIVE PERFORMANCE MAT INC
摘要:There is provided herein a process for the synthesis of sulfonyl silanes. There is also provided herein various sulfenylated and sulfonylated silicon-containing compounds made by the process.

专利号:US-7619116-B2
优先权日:2003-12-17
标 题:Intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation
发明人：DAMBRIN VALERY; LENOIR JEAN-YVES; SCHNEIDER JEAN-MARIE; GUILLAMOT GERARD; FOLLET MICHEL; BECKER ABRAM
权利人:PRODUCTS CHIMIQUES AUXILIAIRES
摘要:A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.

专利号:US-11370736-B2
优先权日:2019-04-01
标 题:Synthesis of fluoro hemiacetals via transition metal-catalyzed fluoro ester and carboxamide hydrogenation
发明人：DUB PAVEL A; BATRICE RAMI J; GORDON JOHN C
权利人:TRIAD NAT SECURITY LLC
摘要:This application is directed to use of transition metal-ligand complexes to hydrogenate fluorinated esters and carboxamides into fluorinated hemiacetals. Methods for synthesis of certain ligands are also provided.