CAS: 52212-02-9; Pipecuroniumbromide

上下游产品

methyl bromide 2β,16β-bis-(4'-methyl-1'-piperazino)-3α,17α-diacetoxy-5α-androstane 2β,16β-bis-(4'-methyl-1'-piperazino)-3α,17β-diacetoxy-5α-androstane

专利信息

专利号:WO-2006038047-A8
优先权日:2004-10-07
标 题:Environment-friend process for the synthesis of quaternary ammonio-steroιds
发明人：TUBA ZOLTAN; MAHO SANDOR; SZABO GYOERGYI; GALIK GYOERGY; BALOGH GABOR
权利人:RICHTER GEDEON VEGYESZET; TUBA ZOLTAN; MAHO SANDOR; SZABO GYOERGYI; GALIK GYOERGY; BALOGH GABOR
摘要:The invention relates to a new, environment-friend process for the synthesis of the known 4,4'-[3α,17β-bis(acetoxy)-5α-androstane-2β,l6β-diyl]-bis(l,l-dimethyl-Ï?iÏ?erazinium) dibromide of formula (I) (from now on pipecuronium bromide) and l-[3α,17β-bis(acetoxy)-2β-(l-piperidinyl)-5α-androstane-16β-yl]-l-methyl-piperidinium bromide of formula (II) (from now on vecuronium bromide). Furthermore the invention relates to the new intermediates of formula (III) and formula (IV) of the process, wherein the meaning of X is benzenesulfonate - in given case para-substituted with a methyl or a nitro group or a bromine atom - methanesulfonate, ethanesulfonate or trifluoromethanesulfonate ion.

专利号:WO-2016009442-A1
优先权日:2014-07-14
标 题 :Novel method for synthesis of neuromuscular blocking agents
发明人：DALVI MAHESH BHAGOJI; TARADE PRADEEP KISAN
权利人:NEON LAB LTD
摘要:The invention discloses a novel method for preparing neuromuscular blocking agents using aryl esters as a reagent of di-acylation as well as highly regioselective mono-acylation of androstane-diols.

专利号:WO-2006038047-A1
优先权日:2004-10-07
标题:Environment-friend process for the synthesis of quaternary ammonio-steroιds

专利号:HU-227522-B1
优先权日:2005-09-02
标题:Environment-friendly process for the synthesis of quaternary amino-steroids and intermediates

专利号:CN-101035801-A
优先权日:2004-10-07
标题:Environmentally friendly method for the synthesis of quaternary ammonium steroids

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.