CAS: 71924-62-4; 2-Fluoro-4,5-Dimethoxybenzaldehyde

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CAS号4885-02-3 1,1-二氯甲醚 | CAS号398-62-9 4-氟-1,2-二甲氧基苯 | CAS号6315-89-5 3,4-二甲氧基苯胺 | CAS号120-14-9 藜芦醛； 3,4-二甲氧基苯甲醛 | CAS号35212-99-8 5,6-二甲氧基苯并噻吩-2-羧酸甲酯 | CAS号23046-03-9 5,6-二甲氧基-1-苯并噻吩-2-羧酸 | CAS号71144-36-0 3,4-二羟基-6-氟苯甲醛 | CAS号853759-47-4 2-[(tert-Butoxy... | CAS号79474-33-2 3,4-DIMETHOXY-6... | CAS号79474-35-4 2-氟-4,5-二甲氧基苯甲酸 | CAS号91407-48-6 2-氟-4,5-二甲氧基苄基氯

3,4-二甲氧基苯胺置于tetrafluoroboric Acid,丁腈,四氯化钛体系中,用 二氯甲烷 作为反应溶剂,化学反应 5.5H,反应生成 6-氟藜芦醛
参考文献:An Improved Synthesis Of 4-Fluoroveratrole. Efficient Route To 6-Fluoroveratraldehyde And 6-Fluoro-D,L-Dopa
标题:An Improved Synthesis Of 4-Fluoroveratrole. Efficient Route To 6-Fluoroveratraldehyde And 6-Fluoro-D,L-Dopa
摘要:
DOI:10.1021/jo00371A032

专利信息

专利号:US-2007213318-A1
优先权日:2006-03-07
标 题 :Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
发明人：MAELICKE ALFRED
权利人:GALANTOS PHARMA GMBH
摘要:The present invention refers to compounds that, in addition to enhancing the sensitivity to acetylcholine and choline of neuronal cholinergic receptors and/or acting as cholinesterase inhibitors and/or neuroprotective agents, have enhanced blood-brain barrier permeability in comparison to their parent compounds. The compounds are derived (either formally by their chemical structure or directly by chemical synthesis) from natural compounds belonging to the class of amaryllidaceae alkaloids e.g. galanthamine, narwedine and lycoramine, or from metabolites of said compounds. The compounds of the present invention can either interact as such with their target molecules, or they can act as “pro-drugsâ€?, in the sense that after reaching their target regions in the body they are converted by hydrolysis or enzymatic attack to the original parent compound and react as such with their target molecules, or both. The compounds of this invention may be used as medicaments for the treatment of human brain diseases associated with a cholinergic deficit, including the neurodegenerative diseases Alzheimer's and Parkinson's disease and the psychiatric diseases vascular dementia, schizophrenia and epilepsy.

专利号:US-2011104055-A1
优先权日:2002-05-31
标题:Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies
发明人：SNOW ALAN; WEIGELE MANFRED; LARSEN LESLEY; NGUYEN BETH; LAKE THOMAS; CASTILLO GERARDO; SANDERS VIRGINIA; WEAVERS REX T; LORIMER STEPHEN; LARSEN DAVID; COFFEN DAVID L; COFFEN CHARLOTTE
权利人:SNOW ALAN; WEIGELE MANFRED; LARSEN LESLEY; NGUYEN BETH; LAKE THOMAS; CASTILLO GERARDO; SANDERS VIRGINIA; WEAVERS REX T; LORIMER STEPHEN; LARSEN DAVID; COFFEN DAVID L; COFFEN CHARLOTTE
摘要:Compounds and their pharmaceutically acceptable salts, their synthesis and labeling, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided. Also provided is the use of the disclosed compounds as imaging agents and methods for in vivo imaging and detection of amyloid and synuclein.

专利号:US-9763953-B2
优先权日:2005-09-22
标题:Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
发明人：MAELICKE ALFRED
权利人:GALANTOS PHARMA GMBH; NEURODYN LIFE SCIENCES INC
摘要:The present invention refers to compounds that, in addition to enhancing the sensitivity to acetylcholine and choline, and their exogenous agonists, of neuronal cholinergic receptors and/or acting as cholinesterase inhibitors and/or neuroprotective agents, have enhanced blood-brain barrier permeability in comparison to their parent compounds. The compounds are derived (either formally by their chemical structure or directly by chemical synthesis) from natural compounds belonging to the class of amaryllidaceae alkaloids e.g., galantamine, narwedine and lycoramine, or from metabolites of said compounds. The compounds of the present invention can either interact as such with their target molecules, or they can act as “pro-drugsâ€?, in the sense that after reaching their target regions in the body they are converted by hydrolysis or enzymatic attack to the original parent compound and react as such with their target molecules, or both. The compounds of this invention may be used as medicaments.

专利号:FR-2930551-A1
优先权日:2008-04-28
标 题:METHODS OF ASYMMETRIC SYNTHESIS OF 6-FLUORO-L-DOPA AND ITS ANALOGUES

专利号:US-9423395-B2
优先权日:2013-01-14
标 题:Fluorescent cell cycle probe having M-phase specificity
发明人：CHANG YOUNG-TAE; ZHAI DUANTING; LEE SUNG-CHAN; YUN SEONG-WOOK; JEONG YUN-MI; KANG NAM-YOUNG; PARK SUNG-JIN
权利人:NAT UNIV SINGAPORE; AGENCY SCIENCE TECH & RES
摘要:The present invention is directed to a novel family of fluorophores based on the BODIPY scaffold, and methods for their synthesis. The BODIPY-based fluorophores disclosed herein are used for the selective visualization of cells that exist in the M-phase of the cell cycle. The present invention further relates to methods for the image-based monitoring of mitotic progression in live cells.

专利号:US-10730849-B2
优先权日:2016-10-04
标 题:Benzo[b]thiophene compounds as STING agonists
发明人：ALTMAN MICHAEL D; CASH BRANDON D; CHANG WONSUK; CUMMING JARED N; HAIDLE ANDREW M; HENDERSON TIMOTHY J; JEWELL JAMES P; LARSEN MATTHEW A; LIANG RUI; LIM JONGWON; LU MIN; OTTE RYAN D; SIU TONY; TROTTER BENJAMIN WESLEY; TYAGARAJAN SRIRAM
权利人:MERCK SHARP & DOHME
摘要:Compounds of general formula (Ia), compounds of general formula (Ia′), compounds of general formula (Ib), compounds of general formula (Ib′), compounds of general formula (I), compounds of general formula (I′), and their pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 8 , R 9 , X 1 , X 2 , and X 3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.