CAS: 1016-58-6; (4,5-Dimethoxy-2-Nitrophenyl)Methanol

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CAS号20357-25-9 6-硝基藜芦醛 | CAS号165811-64-3 4,5-dimethoxy-2... | CAS号42855-00-5 4,5-二甲氧基-2-硝基苄基氯甲酸酯 | CAS号53413-67-5 4,5-二甲氧基-2-硝基溴苄 | CAS号15862-94-9 1-(氯甲基)-4,5-二甲氧... | CAS号163518-08-9 (4,5-dimethoxy-... | CAS号20357-25-9 6-硝基藜芦醛 | CAS号628280-43-3 N-Fm°C DMNB-L-serine

3,4-二甲氧基苄醇置于硝酸,乙酸酐体系中,化学反应 6.0H,以20 G的收率获得4,5-二甲氧基-2-硝基苯甲醇
参考文献:具有抗肿瘤活性的厄洛替尼衍生物及其制备方法和应用
标题:具有抗肿瘤活性的厄洛替尼衍生物及其制备方法和应用
摘要:本发明公开了一种具有抗肿瘤活性的厄洛替尼衍生物及其制备方法和应用,属于具有抗肿瘤活性药物的合成技术领域.本发明的技术方案要点为:具有抗肿瘤活性的厄洛替尼衍生物,其结构式为:,其中r为苯基,对甲基苯基,间硝基苯基,邻氯苯基或邻羟基苯基.本发明还公开了该具有抗肿瘤活性的厄洛替尼衍生物的具体合成过程及其在制备治疗肝癌药物中的应用.本发明通过对厄洛替尼分子进行了改造,在其结构上连接一系列不同的1,2,3‑三氮唑基团,并对合成的厄洛替尼衍生物进行了抗肿瘤活性测试,发现该类化合物对肝癌hepg2细胞具有较好的抑制活性.

专利信息

专利号:US-7956011-B2
优先权日:2005-05-04
标题:Materials and methods for the photodirected synthesis of oligonucleotide arrays
发明人：SERAFINOWSKI PAWEL JERZY; GARLAND PETER BRYAN
权利人:CANCER RES INST ROYAL
摘要:Materials and methods for photodirected synthesis of oligonucleotide arrays on a solid substrate by photodirected synthesis are disclosed which employ a film formed from (i) a photoacid generator that on photolysis generates acid that is capable of directly removing the protecting group of the linker molecules or oligonucleotides and (ii) a polymer substantially lacking electronegative heteroatoms that are capable of hydrogen bonding with photogenerated acid. Methods of synthesizing an oligomer arrays are also described that use a film that restricts diffusion of reactants and products on the substrate during synthesis of the array and which includes a precursor of a deprotecting reagent. The method involves removing one or more of the non-required products of the deprotection reaction from the reactive array elements at which they are produced during the reaction, in order to displace the deprotection reaction towards completion.

专利号:US-5514710-A
优先权日:1994-01-11
标题 :Photocleavable derivatives of hydroxyprenesulfonic acids
发明人：HAUGLAND RICHARD P; GEE KYLE R
权利人:MOLECULAR PROBES INC
摘要:The invention describes the synthesis and use of photoactivated (or caged) fluorescent dyes. Upon illumination at less than about 400 nm the caged dyes release highly fluorescent, water soluble hydroxypyrenesulfonic acid dyes according to the following equation: ##STR1## X, Y, and Z are independently sulfonic acid, a sulfonic acid salt, a hydroxyl group, or hydrogen, with at least one of X, Y, and Z being a sulfonic acid or sulfonic acid salt. LINK is either an ether linkage or a carbonate linkage. BLOCK is a caging group whose photolysis results in liberation of a free hydroxypyrenesulfonic acid dye. n The caged fluorescent dyes are useful for application in aqueous solutions, including fluids of biological origin. The caged dyes of the present invention are especially useful for flow tagging velocimetry.

专利号:US-2008050747-A1
优先权日:2006-03-30
标题:Articles having localized molecules disposed thereon and methods of producing and using same
发明人：KORLACH JONAS; TURNER STEPHEN
权利人:PACIFIC BIOSCIENCES CALIFORNIA
摘要:Sequencing methods and compositions, substrates, devices and systems are provided. Methods include synthesizing a nascent nucleic acid sequence that is greater than 100 bases in length and sequencing the nucleic acids by detecting synthesis. Compositions and substrates that include polymerization complexes for the methods are included.

专利号:WO-2006117556-A3
优先权日:2005-05-04
标 题:Materials and methods for the photodirected synthesis of oligonucleotide arrays

专利号:CN-117659327-A
优先权日:2023-12-13
标题 :Method for catalytic synthesis of novel polyurethane elastomer and application thereof

专利号:US-2009270279-A1
优先权日:2005-05-04
标题 :Materials and Methods for the Photodirected Synthesis of Oligonucleotide Arrays