CAS: 13086-84-5; Di-Tert-Butyl Phosphonate

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CAS号75-65-0 叔丁醇 | CAS号15205-62-6 Phosphorous aci... | CAS号86660-77-7 Phosphonous dia... | CAS号33494-80-3 磷酸二叔丁酯钾盐 | CAS号68695-48-7 磷酸二叔丁酯四正丁基铵盐 | CAS号132541-47-0 4-[bis[(2-methy... | CAS号33494-81-4 磷酸二叔丁基酯 | CAS号16540-40-2 (2-methylpropan... | CAS号174969-89-2 1-[bis[(2-methy... | CAS号229625-50-7 二叔丁基氯甲基磷酸酯 | CAS号115989-10-1 bis[(2-methylpr... | CAS号78543-77-8 di-tert-butylph... | CAS号61922-10-9 ditert-butoxyph...

三-叔-丁基亚磷酸置于硫酸体系中,化学反应生成二叔丁基亚磷酸盐
参考文献:Activated Phosphate Triesters. Synthesis And Reactivity Of N-Hydroxysuccinimide And N-Mercaptosuccinimide Esters
标题:Activated Phosphate Triesters. Synthesis And Reactivity Of N-Hydroxysuccinimide And N-Mercaptosuccinimide Esters
摘要:
Doi:10.1021/jo00942A012

专利信息

专利号:WO-2017082924-A1
优先权日:2015-11-13
标题 :Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE TERRENCE R JR; HYMEL DAVID
权利人:THE US SECRETARY DEPT OF HEALTH & HUMAN SERVICES
摘要:The description provides novel compounds that may serve as anticancer therapeutics. The compounds of the description bind to polo-like kinases through the polo-box domain. The peptide derivatives of the description have achieved improved efficacy in biochemical assays against Plk1. The description also provides methods of use, methods of preparation, compositions, and kits thereof. Further, the description provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.

专利号:US-10905769-B2
优先权日:2015-11-13
标 题:Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; HYMEL DAVID T; TSUJI KOHEI
权利人:THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:The description provides novel compounds that may serve as anticancer therapeutics. The compounds of the description bind to polo-like kinases through the polo-box domain. The peptide derivatives of the description have achieved improved efficacy in biochemical assays against Plk1. Exemplary compounds of the description include macrocyclic peptidomimetics with high affinity and selectivity for polo-like kinases, which may provide the basis for a new genre of anticancer therapeutics. Other exemplary compounds of the description include bi-valent compounds with that bind to polo-like kinases through both kinase domain and polo-box domain simultaneously by incorporating additional moieties that target Plk1 kinase domain, which significantly enhances affinitity relative and may provide the basis for a new genre of anticancer therapeutics. The description also provides methods of use, methods of preparation, compositions, and kits thereof. Further, the description provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.

专利号:US-8445695-B2
优先权日:2003-10-31
标 题 :Synthesis of phosphono-substituted porphyrin compounds for attachment to metal oxide surfaces
发明人：LINDSEY JONATHAN S; LOEWE ROBERT S; MUTHUKUMARAN KANNAN; AMBROISE AROUNAGUIRY
权利人:LINDSEY JONATHAN S; LOEWE ROBERT S; MUTHUKUMARAN KANNAN; AMBROISE AROUNAGUIRY; UNIV NORTH CAROLINA STATE; ZETTACORE INC
摘要:A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.

专利号:US-2009234136-A1
优先权日:2003-10-31
标题:Synthesis of phosphono-substituted porphyrin compounds for attachment to metal oxide surfaces

专利号:US-2005096465-A1
优先权日:2003-10-31
标题:Synthesis of phosphono-substituted porphyrin compounds for attachment to metal oxide surfaces

专利号:US-7314941-B2
优先权日:2003-10-31
标 题:Synthesis of phosphono-substituted porphyrin compounds for attachment to metal oxide surfaces