CAS: 136-47-0; 2-(Dimethylamino)Ethyl 4-(Butylamino)Benzoate Hydrochloride

上下游产品

N-(4-ethoxycarbonylphenyl)butyramide 2-(N,N-dimethylamino)ethanol ethyl 4-(N-butylamino)benzoate 4-nitrobenzoic acid 2-(dimethylamino)ethyl ester2-(N,N-dimethylamino)ethanol 4-(N-butylamino)benzoic acid 2-dimethylaminoethyl 4-(n-butylamino)benzoate β-cyclodextrin 2-dimethylaminoethyl 4-(n-butylamino)benzoate γ-cyclodextrin

4-溴苯甲酸置于硫酸,铜体系中,用 5,5-Dimethyl-1,3-Cyclohexadiene,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 25.0H,反应生成盐酸丁卡因
参考文献:一种盐酸丁卡因的制备方法
标题:一种盐酸丁卡因的制备方法
摘要:本发明公开了一种盐酸丁卡因的制备方法,包括如下步骤:①4‑正丁氨基苯甲酸的制备:在高压反应釜中加入溶剂,4‑卤代苯甲酸,正丁胺及铜催化剂,在一定温度及时间下进行反应,得到4‑正丁氨基苯甲酸;②丁卡因的制备:将步骤①所得4‑正丁氨基苯甲酸以及n,N‑二甲基乙醇胺,浓硫酸,溶剂加入反应瓶中,加热回流分水,得到丁卡因;③盐酸丁卡因的制备:将步骤②所得丁卡因在溶剂中,一定温度下加入浓盐酸反应得到盐酸丁卡因.具有如下优点:1,所用铜催化剂毒性更小,更加安全的同时,也更加廉价易得,极大地减少了原料及运行成本;2,原料易得,反应步骤少,中间反应过程易于控制,副产物少,易于大规模化生产.3,制备的产品纯度及产品总收率高.

专利信息

专利号:US-11407993-B2
优先权日:2017-02-14
标 题 :Method for the synthesis of DNA conjugates by micellar catalysis
发明人：BHAT AVINASH SHASHIDHAR; KLIKA SKOPIC MATEJA; BRUNSCHWEIGER ANDREAS; WEBERSKIRCH RALF
权利人:UNIV DORTMUND TECH
摘要:A method for the synthesis of a chimeric conjugate molecule by micellar catalysis that may form part of DNA-encoded compound libraries. A DNA-coupled organic starter molecule may be reacted with another organic compound, using a catalyst located within a micelle, to form a conjugate of an organic candidate compound coupled to a DNA identifier tag.

专利号:US-3935316-A
优先权日:1975-01-02
标 题:Method of use and formulations
发明人：MOON MALCOLM W
权利人:UPJOHN CO
摘要:A new method for controlling parasitic worms in animals is described. The method employs a new chemical compound: 3-phenylpyruvoyl chloride 1-phenylhydrazone. Formulations of the compound with diluent carriers and adjuvants are discussed and exemplified. A synthesis of the compound is described.

专利号:WO-9925385-A1
优先权日:1997-11-17
标 题:A method of increasing nucleic acid synthesis with ultrasound
发明人：UNGER EVAN C; MCCREERY THOMAS; SADEWASSER DAVID
权利人:IMARX PHARMACEUTICAL CORP
摘要:The present invention is directed to a method of increasing nucleic acid synthesis in a cell comprising administering to the cell a therapeutically effective amount of ultrasound for a therapeutically effective time such that said administration of said ultrasound results in said increased nucleic acid synthesis. The nucleic acid sequence may comprise an endogenous sequence or an exogenous sequence.

专利号:US-9687428-B2
优先权日:2001-05-01
标题 :Hydrogel compositions for tooth whitening
发明人：SINGH PARMINDER; CLEARY GARY W; MUDUMBA SRI; FELDSTEIN MIKHAIL M; BAYRAMOV DANIR F
权利人:A V TOPCHIEV INST OF PETROCHEMICAL SYNTHESIS RUSSIAN ACAD OF SCIENCES; CORIUM INT INC; A V TOPCHIEV INST OF PETROCHEMICAL SYNTHESIS RUSSIAN ACAD OF SCIENCES
摘要:A composition is provided, wherein the composition comprises a water-swellable, water insoluble polymer, a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer, and a whitening agent, preferably a peroxide. The composition finds utility as a tooth whitening composition and is applied to the teeth in need of whitening, and then removed when the degree of whitening has been achieved. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.

专利号:US-2003138490-A1
优先权日:2001-09-08
标 题 :Synthesis and uses of polymer gel nanoparticle networks
发明人：HU ZHIBING; LU XIHUA; GAO JUN; PONDER BILL C; JOHN JOHN ST; MORO DANIEL G
摘要:Disclosed is a new class of nanostructured polymeric materials comprising polymer gel nanoparticles that are covalently bonded through functional groups on the surfaces of neighboring particles. These nanoparticles may be prepared as suspensions in an aqueous or, non-aqueous environment. These gels have two unique and different structural networks; the primary network comprises crosslinked polymer chains in each individual particle, while the secondary network is a system of crosslinked nanoparticles. Particular polymer gel nanoparticle network compositions disclosed herein may function as carriers for controlled delivery of pharmaceuticals or other chemical agents, gel sensors and other commercial applications.

专利号:US-2007036742-A1
优先权日:2005-08-09
标题 :Methods and compositions for modulating hair growth or regrowth
发明人：ROUFS JAMES B; DUVEL LANE A; FAST DAVID J; GLYNN KELLY M
权利人:ACCESS BUSINESS GROUP INT LLC
摘要:The present invention relates to compositions and methods for modulating hair growth or regrowth. The compositions of the present invention comprise extracts of one or more of the following: Boswellia serrata, Undaria pinnatifida, green tea (e.g., Camellia sinensis ), shiso, Pureraria mirifica, luteolin (e.g. Perilla ocymoides leaf extract), astilbin, vitamin E, amentoflavone, tetrahydropiperine, licochalcone, astaxanthin, red clover, Brassica juncea, unfermented green rooibos, enzyme CoQ10, salvia, ximenynic acid, hops oleoresin, apple, soy, saw palmetto, or ellagic extract, or any derivative thereof. In particular, the compositions and methods of the present invention can be used to stimulate or increase hair growth and/or prevent or slow the loss of hair by having one or more of the following functions: (a) inhibiting synthesis of DHT; (b) inhibiting proteasomal activity; (c) inhibiting IL-1 activity; (d) increasing vascularization; (e) increasing expression of vascular endothelial growth factor; (f) increasing expression of keratinocyte growth factor; (g) inhibiting inflammation; or (h) acting as an antibacterial.