CAS: 14197-60-5; (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-Hydroxy-17-((S)-2-Hydroxy-6-Methylhept-5-En-2-yl)-4,4,8,10,14-Pentamethylhexadecahydro-1H-Cyclopenta[a]Phenanthren-3-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-

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CAS号88156-44-9 malonyl-ginseno... | CAS号88140-36-7 malonyl-ginseno... | CAS号88140-43-6 | CAS号88140-35-6 | CAS号88140-34-5 malonylginsenos... | CAS号88140-38-9 6''-malonylgins... | CAS号67400-17-3 (S型)人参皂苷Rh2 | CAS号6892-79-1 Folienetriol

Peracetyl-20(S)-Ginsenoside Rg3置于sodium Hydroxide体系中,用 正丁醇 用作溶剂,以0.21 G的收率获得(20S)人参皂苷 Rg3
参考文献:Metabolism Of 20(S)-And 20(R)-Ginsenoside Rg3 By Human Intestinal Bacteria And Its Relation To In Vitro Biological Activities.
标题:Metabolism Of 20(S)-And 20(R)-Ginsenoside Rg3 By Human Intestinal Bacteria And Its Relation To In Vitro Biological Activities.
摘要:当人参皂苷 Rg3 与人类粪便微生物菌群进行厌氧培养时,所有样本都将人参皂苷 Rg3 代谢为人参皂苷 Rh2 和原人参皂苷.主要代谢产物是人参皂苷 Rh2.20(S)-人参皂苷 Rg3 能迅速转化为 20(S)-人参皂苷 Rh2 或 20(S)-原人参皂苷,其转化量是 20(R)-人参皂苷 Rg3转化为 20(R)-人参皂苷 Rh2 或 20(R)-原人参皂苷的 19 倍.在从人类粪便微生物区系中分离的细菌中,乳杆菌属(bacteroides Sp.),优杆菌属(eubacterium Sp.)和双歧杆菌属(bifidobacterium Sp.)通过人参皂苷 Rh2 将人参皂苷 Rg3 代谢为原人参皂苷.然而,镰刀菌只将人参皂苷 Rg3 代谢为人参皂苷 Rh2.在人参皂苷 Rg3 及其代谢产物中,20(S)-原人参皂苷和 20(S)-人参皂苷 Rh2 对肿瘤细胞株具有最强的细胞毒性,20(S)-和 20(R)-原人参皂苷能够有效抑制幽门螺旋杆菌的生长,20(S)-人参皂苷 Rh2 能够抑制大鼠胃中的 H+/k+ Atpase.
Doi:10.1248/bpb.25.58

专利信息

专利号:WO-2025216332-A1
优先权日:2024-04-08
标题:IMMUNOPOTENTIATING MATERIAL COMPRISING BLACK YEAST β-GLUCAN AND GINSENOSIDE RG3 AND PREPARATION METHOD THEREOF
发明人：KIM UN HUI; KIM YONG HO; KIM SONG IL; HWANG SE JU
权利人:KIM UN HUI
摘要:The immunopotentiating material includes black yeast β-glucan and ginsenoside Rg3, and the content of black yeast β-glucan is 3.5-4.8 g/L and the content of gisenoside Rg3 is 1.3-4.21 mg%. The immunopotentiating materia is prepared by carrying out the synthesis of black yeast β-glucan through the cultivation of black yeast (Aureobasidium pullulans) in the culture medium containing an extract of red ginseng simultaneously with the biotransformation of ginsenosides in the extract of red ginseng by using black yeast (Aureobasidium pullulans). The immunopotentiating materia can be used as an oral administration for anticancer, antitumor and immunopotentiating activities.

专利号:CN-115073538-A
优先权日:2022-07-20
标题 :A new method for the synthesis of the compound arginine fructoside AF in ginseng

专利号:CN-118440917-B
优先权日:2024-04-28
标 题 :A glycosyltransferase mutant and a method for catalyzing the synthesis of ginsenoside Rg3

专利号:CN-118000093-A
优先权日:2024-02-04
标题 :A method for improving the synthesis of physiologically active substances by ginseng and kudzu root

专利号:CN-119286834-A
优先权日:2024-10-30
标题 :Rare ginsenoside damadienol synthesis enzyme and application thereof in preparation of dammaradienol