CAS: 1516887-33-4; (R)-4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-Ethylidene-3-Hydroxy-10,13-Dimethyl-7-Oxohexadecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)Pentanoic Acid

上下游产品

Methyl 3α-Hydroxy-6-Ethylidene-7-Keto-5β-Cholanate 863239-59-2
3α-Hydroxy-6-Ethylidene-7-Keto-5β-Cholanoic Acid-24-Methyl Ester 1516887-32-3

Methyl 3α-Hydroxy-6-Ethylidene-7-Keto-5β-Cholanate置于甲醇,水,Sodium Hydroxide,乙酸乙酯,柠檬酸,3α-Hydroxy-6-Ethylidene-7-Keto-5β-Cholanoic Acid-24-Methyl Ester体系中,用 水 用作溶剂,化学反应 5.17H,以to Produce Compound 5A的收率获得(E)-3α-羟基-6-亚乙基-7-酮-5β-胆-24-酸
参考文献:Preparation And Uses Of Obeticholic Acid
标题:Preparation And Uses Of Obeticholic Acid
摘要:本发明涉及欧贝替胆酸或其药学上可接受的盐,溶剂合物或氨基酸共轭物.欧贝替胆酸对于治疗或预防fxr介导的疾病或情况,心血管疾病或胆汁淤积性肝病以及降低高密度脂蛋白胆固醇,降低哺乳动物的甘油三酯或抑制纤维化方面具有用处.本发明还涉及欧贝替胆酸的合成过程.

专利信息

专利号:US-9982008-B2
优先权日:2012-06-19
标题 :Preparation and uses of obeticholic acid
发明人：STEINER ANDRÉ; WAENERLUND POULSEN HEIDI; JOLIBOIS EMILIE; REWOLINSKI MELISSA; GROSS RALF; SHARP EMMA; DUBAS-FISHER FIONA; EBERLIN ALEX
权利人:INTERCEPT PHARMACEUTICALS INC
摘要:The present invention relates to obeticholic acid: n nor a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid is useful for the treatment or prevention of a FXR mediated disease or condition, cardiovascular disease or cholestatic liver disease, and for reducing HDL cholesterol, for lowering triglycerides in a mammal, or for inhibition of fibrosis. The present invention also relates to processes for the synthesis of obeticholic acid.

专利号:US-9732116-B2
优先权日:2012-06-19
标 题 :Preparation and uses of obeticholic acid
发明人：STEINER ANDRÉ; WAENERLUND POULSEN HEIDI; JOLIBOIS EMILIE; REWOLINSKI MELISSA; GROSS RALF; SHARP EMMA; DUBAS-FISHER FIONA; EBERLIN ALEX
权利人:INTERCEPT PHARMACEUTICALS INC
摘要:The present invention relates to obeticholic acid: n nor a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid is useful for the treatment or prevention of a FXR mediated disease or condition, cardiovascular disease or cholestatic liver disease, and for reducing HDL cholesterol, for lowering triglycerides in a mammal, or for inhibition of fibrosis. The present invention also relates to processes for the synthesis of obeticholic acid.

专利号:EP-3431486-A1
优先权日:2017-07-18
标题 :Process and intermediates for the synthesis of obeticholic acid and derivatives thereof

专利号:US-2020165289-A1
优先权日:2017-07-18
标 题 :Process and intermediates for the synthesis of obeticholic acid and derivatives thereof