CAS: 1632-74-2; 3,6-Dimethylpyridazine

该化合物是一种环环环有机化合物,其3和6个位置上以甲基组替代了一种丙核心,这种结构具有独特的电子和消毒特性,使其成为制药和农用化学合成的宝贵中间体,其僵硬的芳香框架增强了稳定性,而甲基组则促进了受控反应,促进了选择性功能化.该化合物对于生物活性分子的开发特别有用,包括潜在的药物候选体和用于协调化学的离心体. 高纯度可用于确保研究和工业应用的一致性. 其定义明确的化学行为和多功能强调了其在高级合成化学中的实用性.

结构式图片

相似化合物

1632-76-4 49840-90-6 1017793-08-6

欧盟法规

ECHA物质C&L通报

上下游产品

4-chloro-3,6-dimethylpyridazine 2,5-dimethoxy-2,5-dimethyl-2,5-dihydro-furan 3,6-dimethyl-2,3,4,5-tetrahydro-pyridazine-3-carbonitrile 3-hydroxyhexane-2,5-dione 2,4,6-Trimethyl-benzenesulfonate1-amino-3,6-dimethyl-pyridazin-1-ium; 6-(4-ethylphenyl)-2-methylpyrrolo[1,2-b]pyridazine 6-(4-methylphenyl)-2-methylpyrrolo[1,2-b]pyridazine 2,4,6-Trimethyl-benzenesulfonate9-methyl-7,8-diaza-7a-azonia-benzo[k]fluoranthene;

合成工艺路线路线简述

    2,5-二甲基呋喃置于溴,Sodium Carbonate,一水合肼,溶剂黄146体系中,用 甲醇 用作溶剂,化学反应生成3,6-二甲基哒嗪
    参考文献:Fungicidal Pyridazines
    标题:Fungicidal Pyridazines
    摘要:植物通过一系列的吡啶嗪化合物的保护作用,防止了phycomycetous真菌的破坏性影响.其中化学式为##str1##,其中r.Sup.3为氯,溴,甲基,氰基或碘;R为氯,溴,碘,甲基,氰基或呋喃-2-基甲氧基;R.Sup.1为氢,甲基,乙基或正丙基;R.Sup.2为##str2##,X为氟,氯,溴或碘;X.Sup.1和x.Sup.2独立地代表x或氢,前提是x.Sup.1和x.Sup.2中最多只有一个是氢;R.Sup.4为氢,氯,溴,甲基或乙基;R.Sup.5为氢,氯,甲基,乙基,氯甲基或二氯甲基;或者r.Sup.4和r.Sup.5与它们附着的基团结合形成一个取代有r.Sup.1基团的c.Sub.3-C.Sub.7环烷基;R.Sup.6为氢,氯,溴,甲基或乙基;R.Sup.7为氢,甲基,乙基,氯甲基或二氯甲基;M和n中的一个为0或1,另一个为0;P为0-4.

    专利信息


    专利号:WO-2024137329-A1
    优先权日:2022-12-20
    标 题:Methods for the synthesis of complement factor d inhibitors and intermediates thereof
    发明人:HASHIMOTO AKIHIRO; TIPPARAJU SURESH KUMAR
    权利人:ALEXION PHARMA INC
    摘要:The present disclosure provides methods for the synthesis of complement factor D inhibitors and intermediates thereof.

    专利号:US-6794512-B2
    优先权日:2001-11-02
    标 题:Efficient synthesis of 5-heteroatom-containing -pyrazoles
    发明人:SHAVNYA ANDREI; SAYKA SUBAS M; MINICH MARTHA L; RAST BRYSON
    权利人:PFIZER
    摘要:An efficient synthesis of sulfonyl pyrazoles of formula I: n wherein the ring of the formula (R 5 )-A-(SO m R 4 ), m, R 1 through R 9 are as defined in the specification, comprising reacting a compound of formula II: n wherein the ring of the formula (R 5 )-A-(SO m R 4 ), m R 1 through R 9 are as defined above and wherein R 10 is halo, (C 1 -C 6 )alkyl-SO 3 —, (C 6 -C 10 )aryl-SO 3 —, (C 1 -C 6 )alkyl-SO 2 —, or (C 6 -C 10 )aryl-SO 2 —; wherein each of said (C 1 -C 6 )alkyl component of said (C 1 -C 6 )alkyl-SO 3 — and (C 1 -C 6 )alkyl-SO 2 — radicals may optionally be substituted on any carbon atom by one to six fluoro substituents per (C 1 -C 6 )alkyl component; with a compound of formula R 3 —H, wherein R 3 is as defined above, in the presence of a fluoride containing salt and in the presence of a solvent.

    专利号:WO-2024037615-A1
    优先权日:2022-08-19
    标 题:Ionic covalent organic framework material, solid-phase synthesis method thereof, and use thereof
    发明人:ZHANG ZHENJIE; ZHANG PENGHUI; WANG ZHIFANG; ZHANG YUSHU; CHEN YAO
    权利人:YOCOF MAT TIANJIN CO LTD
    摘要:The present invention provides a series of ionic vinyl covalent organic framework materials constructed in two ways by means of designing a novel method. Such materials feature high crystallinity and specific surface area, cost-efficiency, simple synthesis, capability of self-forming and mass production, and the like. The synthesis process avoids the use of organic solvents and thus the risks of high pressure during the reaction process, and thereby possesses suitability for mass production and industrial potential. In addition, the ionic COF materials have the capability of efficiently isolating oxygen-containing anions from water, and have great industrial application prospects.

    专利号:US-8207337-B2
    优先权日:2007-01-29
    标 题:Reagent for organic synthesis reaction containing organic triol borate salt
    发明人:MIYAURA NORIO; YAMAMOTO YASUNORI
    权利人:MIYAURA NORIO; YAMAMOTO YASUNORI; WAKO PURE CHEM IND LTD
    摘要:[Problem] n To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. n [Means for Solving Problems] n The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R 1 represents alkyl, alkenyl, etc.; R 2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m + represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M 2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).

    专利号:WO-2023114200-A2
    优先权日:2021-12-14
    标题 :Methods for the synthesis of complement factor d inhibitors and intermediates thereof

    专利号:US-2003139407-A1
    优先权日:2001-11-02
    标 题 :Efficient synthesis of 5-heteroatom-containing -pyrazoles
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    合成参考文献


    摘要:Zhang, J., Science of Synthesis Knowledge Updates, (2010) 4, 243.
    摘要:J. Levisalles. Bull. Soc. Chim. France 1957, 1009.
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