CAS: 169689-05-8; N,N'-((1S,2S)-Cyclohexane-1,2-Diyl)Bis(2-(Diphenylphosphino)Benzamide)

专利信息

专利号:US-12275750-B2
优先权日:2019-07-22
标 题 :1,2-bis(diphenylphosphinoalkylamido)-1,2-disubstituted ethane, and its synthesis and application
发明人：MA SHENGMING; ZHANG YUCHEN
权利人:UNIV ZHEJIANG
摘要:The present invention relates to the design and synthesis of a class of novel chiral phosphine ligand, 1,2-bis(diphenylphosphinoalkylamido)-1,2-disubstituted ethane, and use in asymmetric catalytic reactions, such as asymmetric catalytic synthesis of pyrazoline-5-one with a chiral quaternary carbon center, i.e., highly enantioselective synthesis of 3-methyl-4-benzyl-4-(2-butyl-2,3-butadienyl)pyrazoline-5-one by using 3-methyl-4-benzylpyrazoline-5-one and benzyl (2-butyl-2,3-butadienyl) carbonate with tris(dibenzylideneacetone)dipalladium-chloroform adduct and this novel ligand as catalysts. The ligand designed by this present invention has the following advantages: the structure is novel, the synthesis and enlarge are simple, the enantioselective control effect in the practical reaction is excellent, which has a broad application prospect in chiral catalysis.

专利号:US-9951096-B2
优先权日:2008-08-22
标 题 :Catalysts and methods for polymer synthesis
发明人：ALLEN SCOTT D; CHERIAN ANNA E; SIMONEAU CHRIS A; FARMER JAY J; COATES GEOFFREY W; GRIDNEV ALEXEI; LAPOINTE ROBERT E
权利人:SAUDI ARAMCO TECH CO
摘要:The present invention provides unimolecular metal complexes having increased activity in the copolymerization of carbon dioxide and epoxides. Also provided are methods of using such metal complexes in the synthesis of polymers. According to one aspect, the present invention provides metal complexes comprising an activating species with co-catalytic activity tethered to a multidentate ligand that is coordinated to the active metal center of the complex.

专利号:US-2024199569-A1
优先权日:2022-11-30
标 题:Process for the manufacture of inhibitors of kras
发明人：ZHANG YONGDA; CHONG EUGENE; REEVES JONATHAN TIMOTHY; WHITE JADA A H; LEI ZHEN
权利人:BOEHRINGER INGELHEIM INT
摘要:This invention relates to an efficient and enantioselective synthesis of the spiro-compounds of formula (1) as common intermediate, featuring an asymmetric introduction of the all-carbon quaternary centre in high selectivity and a very efficient one-pot procedure for the C2 elongation to generate the spiro-structure.For the all-carbon quaternary centre, a Tsuji-Trost asymmetric allylic alkylation (AAA) process was designed to develop a sustainable procedure with very low catalyst loading, thereby also facilitating the Pd content control in the product, under practically solvent free conditions. Furthermore, multiple synthetic transformations in a one-pot procedure were implemented by using a one-pot procedure either in form of a three-transformation sequence comprising Hydroboration-Alkylation-Dieckmann Condensation to compound of formula (1) or in form of a five-transformation sequence comprising Hydroboration-Alkylation-Dieckmann Condensation-Hydrolysis-Decarboxylation to compound of formula (9).

专利号:US-2025010279-A1
优先权日:2021-11-17
标 题:Synthesis of carbonylation catalysts
发明人：WILDERS ALISON M; TEDDER JONATHAN D; BOYCE RONALD; JOSEPH ASHLEY
权利人:NOVOMER INC
摘要:A method including contacting a ligand complex, a metalation compound, and a metal carbonyl in a mixture to form a catalyst. The ligand complex includes one or more of phosphine, imine, and/or hydroxyl groups bound to one or more cyclic structures. The method includes separating the catalyst from the mixture. Contacting the ligand complex with a metalation compound and the metal carbonyl in the mixture to form a catalyst is conducted without isolating any intermediates, performed within a single vessel, and/or performed in a moisture, oxygen, and/or air free environment.

专利号:US-2016318862-A1
优先权日:2013-09-25
标 题:Synthesis of delta 12-pgj3 and related compounds
发明人：NICOLAOU KYRIACOS C; HERETSCH PHILIPP; HALE CHRISTOPHER R H; EL GHZAOUI ABDELLATIF EL MARROUNI; PULUKURI KIRAN KUMAR; YU RUOCHENG; GROVE CHARLES
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of Δ 12 -PGJ 3 and modular synthetic pathways to obtaining Δ 12 -PGJ 3 and derivatives thereof. In some aspects, the present derivatives of Δ 12 -PGJ 3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.

专利号:US-12377405-B2
优先权日:2014-07-25
标题:Synthesis of metal complexes and uses thereof
发明人：LEE HAN
权利人:NOVOMER INC
摘要:The present disclosure provides novel methods of making aluminum complexes with utility for promoting epoxide carbonylation reactions. Methods include reacting neutral metal carbonyl compounds with alkylaluminum complexes, such as the alkylaluminum complexes represented by Formula I, where Q is a nitrogen atom and the four Q groups are part of a single porphyrin ligand and Rq is selected from optionally substituted C1-12 aliphatic and optionally substituted aryl: