CAS: 365996-30-1; Tert-Butyl ((1S,2R)-2-Aminocyclohexyl)Carbamate

该化合物是化学化合物,其特点是其碳酸衍生物的氨基甲酸酯反应产生的碳酸衍生物,其特性为碳酸衍生物的矿山反应,该化合物的特性为叔丁基乙基,其形成会影响其再活性和溶性;环丁基结构的存在有助于其一致性灵活性,而氨基中心(1S 2R)的特定立体化学对于其生物活动和与受体或酶的相互作用至关重要.通常,这种化合物可能具有中度极性,使其溶于有机溶剂中,但较少在水中产生这种特性.该化合物还可能对医药化学,特别是制药业感兴趣,因为其作为建筑块或活性药物成分的潜在作用.应当与任何化学物质一样,遵守安全和谨慎措施,以减少与接触有关的风险.

英文名称Tert-Butyl ((1S,2R)-2-Aminocyclohexyl)Carbamate
中文名称((1S,2R)-2-氨基环己基)氨基甲酸叔丁酯
IUPAC名称tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate
其它别名(1S,2R)-N1-(叔丁氧羰基)-1,2-环己烷二胺; (1S,2R)-N1-Boc-1,2-Cyclohexanediamine
CAS编号365996-30-1
MFCD编号:MFCD09952105
EINECS号:690-960-2
分子式:C11H22N2O2
分子量:214.3
产品CID: 1375312
产品分类有机原料→分子砌块→脂肪环类化合物→环己烷类化合物

相似结构搜索
InChIKey: AKVIZYGPJIWKOS-BDAKNGLRSA-N
InChI=1S/C11H22N2O2/c1-11(2,3)15-10(14)13-9-7-5-4-6-8(9)12/h8-9H,4-7,12H2,1-3H3,(H,13,14)/t8-,9+/m1/s1…
计算化学: 氢键受体数3.0氢键供体数2.0可旋转键数1.0

相似化合物

146504-07-6 317595-54-3 137731-41-0

MSDS等安全信息

GHS象形图
GHS符号GHS05;
注释: Corrosion
危险类别皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
严重眼损伤类别1
急性毒性类别4(吸入)
急性毒性类别4(经皮)
警示词Danger(危险)
危险描述H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H318 |造成严重眼损伤.
H332 |吸入有害.
H312 |皮肤接触有害.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险等级IRRITANT
危险品标志Xi
安全声明26-39
危险类别码38-41
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

合成目标产物 Carbamic Acid, [(1S,2R)-2-Aminocyclohexyl]-, 1,1-Dimethylethyl Ester (9CI) 主要起始原料 Carbamic Acid, [(1R,2S)-2-Aminocyclohexyl]-, 1,1-Dimethylethyl Ester (9CI)
1123685-32-4 = 365996-30-1
反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; 2 H,Reflux
标题:Discovery And Structure-Activity Relationships Of 4-Aminoquinazoline Derivatives,A Novel Class Of Opioid Receptor Like-1 (Orl1) Antagonists
作者:Okano,Masahiko; Mito,Jun; Maruyama,Yasufumi; Masuda,Hirofumi; Niwa,Tomoko; Et Al
参考文献:Bioorganic & Medicinal Chemistry 日期:2009 卷标:17(1) 页码:119-132]

1261082-39-6 = 365996-30-1
反应条件:1.1 Reagents: Dimethylbarbituric Acid Catalysts: Triphenylphosphine,Palladium Diacetate Solvents: Dichloromethane; 24 H,Rt
标题:The Meso Helix: Symmetry And Symmetry-Breaking In Dynamic Oligourea Foldamers With Reversible Hydrogen-Bond Polarity
作者:Wechsel,Romina; Raftery,James; Cavagnat,Dominique; Guichard,Gilles; Clayden,Jonathan
参考文献:Angewandte Chemie 日期:2016 卷标:55(33) 页码:9657-9661]

1261082-39-6 = 365996-30-1
反应条件:1.1 Reagents: Dimethylbarbituric Acid Catalysts: Triphenylphosphine,Palladium Diacetate Solvents: Dichloromethane; 24 H,Rt
标题:Enantiopure Monoprotected Cis-1,2-Diaminocyclohexane: One-Step Preparation And Application In Asymmetric Organocatalysis
作者:Berkessel,A.; Ong,M.-C.; Nachi,M.; Neudoerfl,J.-M.
参考文献:Chemcatchem 日期:2010 卷标:2(10) 页码:1215-1218]

365996-28-7 = 365996-30-1
反应条件:1.1 Reagents: Sodium Azide Solvents: Dimethylformamide; Overnight,80 °C1.2 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol; 6 H,Rt
标题:Sar And X-Ray Structures Of Enantiopure 1,2-Cis-(1R,2S)-Cyclopentyldiamine And Cyclohexyldiamine Derivatives As Inhibitors Of Coagulation Factor Xa
作者:Qiao,Jennifer X.; Chang,Chong-Hwan; Cheney,Daniel L.; Morin,Paul E.; Wang,Gren Z.; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2007 卷标:17(16) 页码:4419-4427]

365996-29-8 = 365996-30-1
反应条件:1.1 Reagents: Hydrogen Catalysts: Platinum Dioxide Solvents: Methanol; 3 H,35 - 40 Psi,Rt
标题:Synthesis And Evaluation Of (1S,2R/1R,2S)-Aminocyclohexylglycyl Pnas As Conformationally Preorganized Pna Analogues For Dna/rna Recognition
作者:Govindaraju,T.; Kumar,Vaijayanti A.; Ganesh,Krishna N.
参考文献:Journal Of Organic Chemistry 日期:2004 卷标:69(6) 页码:1858-1865

(1S,2S)-2-Azidocyclohexanol置于platinum(Iv) Oxide 吡啶,4-二甲氨基吡啶,Sodium Azide,氢气体系中,用甲醇,乙酸乙酯,N,N-二甲基甲酰胺作为反应溶剂,72.0 °C,275.79 Kpa 条件下,反应 30.0H,反应生成 [(1S,2R)-2-氨基环己-1-基]氨基甲酸叔丁酯
参考文献:(1S,2R/1R,2S)-Aminocyclohexyl Glycyl Thymine Pna: Synthesis,Monomer Crystal Structures,And Dna/rna Hybridization Studies
标题:(1S,2R/1R,2S)-Aminocyclohexyl Glycyl Thymine Pna: Synthesis,Monomer Crystal Structures,And Dna/rna Hybridization Studies
摘要:Graphicthe Synthesis Of Ethyl Cis-(1S,2R/1R,2S)-2-Aminocyclohex-1-Yl-N-(Thymin-1-Yl-Acetyl) Glycinate (10A And 10B) Via Enzymatic Resolution Of The Key Racemic Intermediate Trans-2-Azido Cyclohexanols 3 Is Reported. The Crystal Structures Of 10 Show Equatorial Disposition Of The Tertiary Amide Group,With The Torsion Angle Beta In The Range 60-70Degrees. The Pna Oligomers Incorporating These Show Differential Effects In Hybridizing With Complementary Dna And Rna.
DOI:10.1021/ol034933M