专利号:US-2023097824-A1 优先权日:2020-05-08 标 题:Semi-synthesis and use of racemic hematoxylin 发明人:DURRANT EDWARD E; HEINDL DIETER; HUBER FLORIAN MAURITIUS ERASUMU; KLEIN ERIC; KOSMEDER II JEROME W; VOSS EDGAR 权利人:VENTANA MED SYST INC; ROCHE DIAGNOSTICS OPERATIONS INC 摘要:A racemic hematoxylin formulation is disclosed that includes one or both of a stabilizer compound and an antioxidant. The disclosed composition exhibits sufficient stability to be utilized in an automated staining process. Methods of using and making the stabilized composition also are disclosed.
专利号:US-12421186-B2 优先权日:2022-11-29 标 题 :Organic ammonium salts with traceability and detergent dispersant properties to liquid fuels and processes for their synthesis 发明人:CAMACHO RICARDO CERÓN; ROA RAÚL OVIEDO; RAMÃ?REZ PÉREZ JORGE FRANCISCO; CASTRUITA ENRIQUE SOTO; DÉVORA RODOLFO CISNEROS; NIETO Ã?LVAREZ DAVID AARON; MARTINEZ MAGADAN JOSÉ MANUEL; SERVÃ?N NÃ?JERA Ana Graciela; ZAMUDIO RIVERA LUIS SILVESTRE 权利人:MEXICANO INST PETROL 摘要:The present invention is related to a process for obtaining organic ammonium salts (OAS) and their derivatives, supramolecular surfactants (SS), which simultaneously present the properties of traceability and detergents dispersant of organic scales. Organic ammonium salts (OAS) and their derivatives supramolecular surfactants (SS) have applications as differentiators, markers, or tracers in fuels derived from hydrocarbons; and also to disperse organic scales or inhibit the gums precipitation both in injectors and intake valves of automotive vehicle engines. Organic ammonium salts (OAS) are obtained through an acid-base reaction between a molecule from the azo family and an amine. Once the OAS is obtained, it reacts with an organic compound (OC) so that through non-covalent interactions, a self-assembly process occurs that gives rise to the SS. Said process is based on green chemistry, that is, in the absence of solvents. These OAS and SS are quantified through the analytical techniques of ultraviolet-visible (UV-VIS) and high-performance liquid chromatography (HPLC) through a calibration curve. Additionally, its performance as a gum-dispersing agent in a single-cylinder engine is evaluated.
专利号:EP-4206236-A1 优先权日:2021-12-28 标题 :Compounds, their synthesis and compositions comprising the compounds for enhanced deposition of polymers onto hair surfaces 发明人:BREAKSPEAR STEVEN; NÖCKER BERND; WEITZEL JOHANNA; PAEZ JULIETA; PEARSON SAMUEL; BRÜCK STEFAN; CAMPO ARANZAZU DEL 权利人:KAO CORP 摘要:The present invention is on polymers derivatized with an organic deposition-enhancing group for their enhanced deposition onto keratin fibers, especially human hair. The deposition-enhancing group is a di-hydroxyl phenolic compound with a spacer alkyl group bound to a reactive amine or carboxyl group, which reacts with one of the hydroxyl, carboxyl, primary and secondary amine groups on the polymeric backbone. The invention is on the method of synthesizing such compounds and compositions comprising the compounds.
专利号:US-2023271983-A1 优先权日:2020-07-29 标题 :Functionalized isonitriles and products, preparation and uses thereof 发明人:SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA 权利人:UNIV SANTIAGO COMPOSTELA 摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.
专利号:WO-2024097977-A1 优先权日:2022-11-04 标题:Silk nanoparticle synthesis: tuning size, dispersity, and surface chemistry for drug delivery 发明人:SHAIDANI SAWNAZ; FALCUCCI THOMAS; FOSTER OLIVIA; SAHOO JUGAL KISHORE; HASTURK ONUR; KAPLAN DAVID L; JACOBUS CHARLOTTE S 权利人:TUFTS COLLEGE 摘要:Methods disclosed herein relate to generating silk nanoparticles with a low polydispersity index (PDI). Methods include adding a silk solution dropwise into a volatile solvent that is miscible with water, thereby forming a precipitate-bearing solution and applying shear forces to the precipitate-bearing solution for a length of time sufficient to achieve evaporation of at least 95% of the volatile solvent, thereby producing a population of silk fibroin nanoparticles in water having a polydispersity index (PDI) of 0.35 or less, including but not limited to, a PDI of 0.330 or less, 0.325 or less, 0.315 or less, 0.310 or less, 0.30 or less, 0.275 or less, 0.250 or less, 0.225 or less, or 0.200 or less. Parameters related to silk fibroin molecular weight, silk fibroin concentration, shear force application, and temperature may all be modified to achieve silk nanoparticles of a particular size exhibiting particular PDIs.
专利号:US-2020392562-A1 优先权日:2017-12-22 标 题:Polymerase chain reaction composition comprising amines 发明人:Matjosaitis Karolis; RIMKUS RENALDAS; VANAGAS LAURYNAS; SUKACKAITE RASA; Valinskyte Skaiste; ELIJOSIUTE EDITA; STREPETKAITE DOVILE 权利人:THERMO FISHER SCIENTIFIC BALTICS UAB 摘要:Compositions, methods, and kits comprising amines are described for use in nucleic acid synthesis. In some embodiments, amines improve nucleic acid synthesis product yield or tolerance to inhibitors of nucleic acid synthesis.
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 1985. Acute oral toxicity and repellency of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology 14:111-129. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/S_schafer851.pdf