CAS: 381233-96-1; 5-Bromo-3-Iodopyridin-2-Amine

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2-氨基-5-溴吡啶置于水合硫酸,Periodic Acid Dihydrate,碘,溶剂黄146体系中,化学反应 7.0H,以70%的收率获得2-氨基-5-溴-3-碘吡啶
参考文献:一系列双环hiv-1整合酶抑制剂的设计.第1部分:脚手架的选择
标题:一系列双环hiv-1整合酶抑制剂的设计.第1部分:脚手架的选择
摘要:提出了一种基于新型双环嘧啶酮核心的hiv整合酶抑制剂.评价了核心支架的九种变异,从而优化了6:6核心,从而得到了针对野生型hiv感染t细胞的ec 50为3 Nm的化合物48.
Doi:10.1016/j.Bmcl.2010.07.079

专利信息

专利号:US-2006183758-A1
优先权日:2005-02-17
标 题:Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
发明人：BEARD CHARLES D; LEE VING J; WHITTLE C E
权利人:CB RES AND DEV INC
摘要:Methods of synthesis of intermediates that are useful as bioisosteres of the indole, benzofuran and benzothiophene scaffold are disclosed.

专利号:US-9493461-B2
优先权日:2013-02-07
标 题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C
发明人：DAI XING; LIU HONG; PALANI ANANDAN; HE SHUWEN; LAI ZHONG; NARGUND RAVI; MARCANTONIO KAREN; XIAO DONG; BROCKUNIER LINDA L; ZORN NICOLAS; DANG QUN; PENG XUANJIA; LI PENG
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9695147-B2
优先权日:2013-07-25
标题 :Process for the preparation of perampanel
发明人：BUCHLOVIC MARIAN
权利人:TEVA PHARMACEUTICALS INT GMBH
摘要:The present invention provides intermediates useful for the synthesis of Perampanel and processes employing said intermediates for preparing Perampanel. The invention also provides processes for making the intermediates, crystalline forms of the intermediates and the use of the crystalline forms for preparing Perampanel.

专利号:US-9556172-B2
优先权日:2010-07-21
标 题:Processes for the manufacture of propane-1-sulfonic acid (3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl)-amide
发明人：BRUMSTED COREY JAMES; MOORLAG HENDRIK; RADINOV ROUMEN NIKOLAEV; REN YI; WALDMEIER PIUS
权利人:HOFFMANN LA ROCHE; HOFFMAN LA-ROCHE INC
摘要:According to the present invention there are provided novel processes for the manufacture of the compound of formula 1 n nas well as intermediates and novel synthesis routes for key intermediates used in those processes.

专利号:US-7772246-B2
优先权日:2007-08-01
标题:Pyrazole compounds as RAF inhibitors
发明人：CUI JINGRONG JEAN; DEAL JUDITH GAIL; GU DANLIN; GUO CHUANGXING; JOHNSON MARY CATHERINE; KANIA ROBERT STEVEN; KEPHART SUSAN ELIZABETH; LINTON MARIA ANGELICA; MCALPINE INDRAWAN JAMES; PAIRISH MASON ALAN; PALMER CYNTHIA LOUISE
权利人:PFIZER
摘要:The present invention is directed to compounds of Formula (I), n nand to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.