CAS: 421-49-8; 1,1,1-Trifluoropropan-2-Amine

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2968-32-3 177469-12-4 125353-44-8

上下游产品

CAS号34226-10-3 1,1,1-trifluoro... | CAS号431-40-3 1,1,1-三氟-2-丙酮肟 | CAS号302-72-7 DL-2-氨基丙酸 | CAS号917-64-6 甲基碘化镁 | CAS号353-85-5 三氟乙腈

N-(1-三氟甲基-亚乙基)苄胺置于1,8-二氮杂双环[5.4.0]十一碳-7-烯,苄胺体系中,用 甲苯 作为反应溶剂,以17 G的收率获得产物a-三氟甲基乙胺
参考文献:Chemoenzymatic Dynamic Kinetic Resolution Of α-Trifluoromethylated Amines: Influence Of Substitutions On The Reversed Stereoselectivity
标题:Chemoenzymatic Dynamic Kinetic Resolution Of α-Trifluoromethylated Amines: Influence Of Substitutions On The Reversed Stereoselectivity
摘要:首次比较研究了通过动力学分辨 (Kr),动态动力学分辨 (Dkr) 采用 Calb-Pd/al2O3 催化,及 Kr/dkr/kr 一锅顺序过程对 α-三氟甲基化胺的酶解分辨.尽管 Calb 催化的 α-三氟甲基化胺与甲基 (1A),异丙基 (1C),苯基 (1D) 和苄基 (1E) 取代基的 Kr 可以提供非常好的立体选择性因子 E,从 31 到超过 200,但 Dkr 和 Kr/dkr/kr 的顺序过程由于更高的转化率 (62%-84%) 和相似的对映体过量 (90%-99%),具有更好的实际应用潜力.通过分子对接模式观察并解释了 Calb 显示出的对 α-三氟甲基化胺的对映选择性和反转.即对于 1,1,1-三氟-2-丙胺 (1A),获得了 R 构型的酰胺产物,对于取代基大于甲基的胺 (1B-1E),对映选择性则转换为 S.催化剂的回收和放大实验成功演示.这些结果表明该酶促过程高效且环保,具有重要的应用意义.
DOI:10.1039/c3Ra40526E

专利信息

专利号:US-6013838-A
优先权日:1998-01-27
标题:Chemical intermediates bearing a trifluoromethyl group
发明人：VAN DER PUY MICHAEL
权利人:ALLIED SIGNAL INC
摘要:Novel trifluoromethylated intermediates are provided which are useful in synthesizing trifluoromethylated organic compounds. Specifically, compounds of the formula CF 3 CR are provided, wherein R is (Cl)â•?CHCH 2 SO 2 Ph, (Cl)â•?CHCH 2 CH 2 C(â•?O)CH 3 , (Cl)â•?CHCH 2 CH(COCH 3 ) 2 , (Cl)â•?CHCH 2 NR'R' or Hâ•?CHCHâ•?NR'; R' and R' are the same or different and are selected from the group consisting of hydrogen, unsubstituted or substituted C 1 to C 6 straight chain or branched alkyl, unsubstituted or substituted C 3 to C 7 cycloalkyl, unsubstituted or substituted C 2 to C 12 alkenyl, a benzyl group unsubstituted or substituted with R'', or a phenyl group unsubstituted or substituted with R''; or R' and R' taken together form a five- or six-membered ring; and R'' is an unsubstituted or substituted C 1 to C 6 straight chain or branched alkyl, an unsubstituted or substituted C 1 to C 6 alkoxy, an unsubstituted or substituted C 1 to C 6 thioakyl, a cyano, a halogen, or a C 1 to C 2 dialkylamino group; with the proviso that when the alkyl, cycloalkyl or alkenyl of R' or R' or the alkyl, alkoxy or thioalkyl of R'' is substituted, it may be substituted with any group compatible with amine functionality. The novel compounds are versatile intermediates for the synthesis of a wide variety of trifluoromethylated organic compounds, which have found great utility as pharmaceuticals, agricultural chemicals, and materials such as liquid crystals.

专利号:CN-103772156-B
优先权日:2014-01-06
标题 :Method of continuous catalytic synthesis of 1-alkoxyl-1,1,2,2-tetrafluoroethane in fixed bed

专利号:CN-103772156-A
优先权日:2014-01-06
标题 :A method for the continuous catalytic synthesis of 1-alkoxy-1,1,2,2-tetrafluoroethane in a fixed bed