CAS: 6258-60-2; 4-Methoxy-A-Toluenethiol

上下游产品

1,2-bis(4-methoxybenzyl)disulfide p-Methoxybenzyl bromide thiourea p-methoxybenzyl chloride 1-ethanesulfonylmethyl-4-methoxy-benzene 1,2-bis(4-methoxyphenyl)ethene 5-(4-methoxy-benzylsulfanyl)-thiazole-4-carboxylic acid ethyl ester dithiooxalodiimidic acid bis-(4-methoxy-benzyl) ester

4-甲氧基苄醇置于劳森试剂体系中,用 甲苯 作为反应溶剂,化学反应 48.0H,反应生成 4-甲氧基苄硫醇
参考文献:原位反应生成的半硫缩醛的非酶动力学动力学拆分:访问1,3-二取代的邻苯二甲酰胺.
标题:原位反应生成的半硫缩醛的非酶动力学动力学拆分:访问1,3-二取代的邻苯二甲酰胺.
摘要:开发了半硫缩醛的第一个非酶促dkr反应.半硫缩醛是通过添加硫醇原位形成的,随后进行了分子内的氧杂-迈克尔反应.反应的范围很广,从脂族取代基到芳族取代基,均以非常好的收率,中等的非对映选择性和高对映选择性获得了1,3-二取代-1,3-二氢异苯并呋喃产物.
DOI:10.1002/adsc.201701518

专利信息

专利号:US-8012993-B2
优先权日:2006-12-28
标题 :Stable S-nitrosothiols, method of synthesis and use
发明人：MOLINER JOSE REPOLLES; COY FRANCISCO PUBILL; MANCINI MARISABEL MOURELLE; NIETO JUAN CARLOS DEL CASTILLO; LLORENTE LYDIA CABEZA; BONIN JUAN MARTINEZ; SALADRIGAS ANA MODOLELL
权利人:LACER SA
摘要:The present invention relates to stable S-nitrosothiols derivatives of formula (I) n nhaving vasodilating effect and which inhibit the aggregation of the platelets and which therefore are useful for the preparation of medicaments for treatment of NO related diseases. The invention also relates to a process for the synthesis of the compounds of formula (I).

专利号:WO-9955664-A1
优先权日:1998-04-24
标 题 :Preparation of carbocyclic compounds
发明人：BECKER MARK W; CHAPMAN HARLAN H; KELLY DAPHNE E; KENT KENNETH M; LEW WILLARD; LOUIE MICHAEL S; MCGEE LAWRENCE R; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; SCHULTZE LISA M; YU RICHARD H; ZHANG LIJUN
权利人:GILEAD SCIENCES INC; BECKER MARK W; CHAPMAN HARLAN H; KELLY DAPHNE E; KENT KENNETH M; LEW WILLARD; LOUIE MICHAEL S; MCGEE LAWRENCE R; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; SCHULTZE LISA M; YU RICHARD H; ZHANG LIJUN
摘要:The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

专利号:US-6518438-B2
优先权日:1996-08-23
标题:Preparation of cyclohexene carboxylate derivatives
发明人：KENT KENNETH M; KIM CHOUNG U; MCGEE LAWRENCE R; MUNGER JOHN D; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; KELLY DAPHNE E; WILLIAMS MATTHEW A; ZHANG LIJUN
权利人:GILEAD SCIENCES INC
摘要:The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

专利号:US-5886213-A
优先权日:1997-08-22
标题:Preparation of carbocyclic compounds
发明人：KENT KENNETH M; KIM CHOUNG U; MCGEE LAWRENCE R; MUNGER JOHN D; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; KELLY DAPHNE E; WILLIAMS MATTHEW A; ZHANG LIJUN
权利人:GILEAD SCIENCES INC
摘要:The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

专利号:US-6204398-B1
优先权日:1996-08-23
标题 :Preparation of cyclohexene carboxylate derivatives
发明人：KENT KENNETH M; KIM CHOUNG U; MCGEE LAWRENCE R; MUNGER JOHN D; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; KELLY DAPHNE E; WILLIAMS MATTHEW A; ZHANG LIJUN
权利人:GILEAD SCIENCES INC
摘要:The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates such as those having formulas (I)-(IV), useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

专利号:US-11365211-B2
优先权日:2018-02-01
标 题 :Stereoselective synthesis and process for the manufacturing of 2′-deoxynucleosides
发明人：ZHANG LIANHAO; VISHNUVAJJALA BABURAO; MORRIS JOEL; BAHDE ROBERT; DENYSENKO SERGIY M; LOPEZ OMAR DIEGO; WISHKA DONN GREGORY
权利人:THE USA AS REPRESENTED BY THE SEC DEP OF HEALTH AND HUMAN SERVICES; ALCHEM LABORATORIES CORP; US HEALTH
摘要:Methods for stereoselective synthesis and manufacturing of 2′-deoxynucleosides, such as 2′-ribonucleosides, are disclosed. In some embodiments, the 2′-deoxynucleoside is a β-anomer of a 2′-deoxynucleoside having a 3′ α hydroxyl, 4′ β hydroxymethyl configuration. Nonlimiting examples of compounds prepared by the disclosed methods include 4′-thio-2′-deoxycytidine (T-dCyd) and 5-aza-4′-thio-2′-deoxycytidine (5-aza-T-dCyd; aza-T-dCyd; aza-T-dC).