CAS: 6775-78-6; 6-Chloroimidazo[1,2-B]Pyridazine

相似化合物

40972-42-7 933190-51-3 14793-00-1

上下游产品

3-(2-Hydroxy-ethylamino)-6-chlor-pyridazin 2-chloroethanal 6-chloro-pyridazin-3-ylamine bromoacetaldehyde pyrazolopyridazine6-Chloro-9-methyl-9-phenyl-9H-imidazo1,2-bpyrazolo4,3-dpyridazine pyrazolopyridazine6-Chloro-9-methyl-9-phenyl-7,8-dihydro-9H-imidazo1,2-bpyrazolo4,3-dpyridazine 3-bromo-6-chloro-imidazo[1,2-b]pyridazine pyridazine6-chloro-3-nitroimidazo1,2-bpyridazine

2-[(6-氯吡嗪-3-基)氨基]乙醇置于草酰氯,二甲基亚砜,三乙胺体系中,用 二氯甲烷 作为反应溶剂,以82%的收率获得产物6-氯咪唑并[1,2-B]哒嗪
参考文献:在swern氧化条件下高效制备咪唑并[1,2-B]哒嗪
标题:在swern氧化条件下高效制备咪唑并[1,2-B]哒嗪
摘要:通过在swern氧化条件下形成咪唑环,用各种2-羟基乙胺处理3,6-二氯哒嗪,可以有效合成新的咪唑并[1,2-B]哒嗪衍生物.讨论了环化步骤的一些机械方面.
DOI:10.1016/s0040-4039(03)00426-X

专利信息

专利号:US-10000487-B2
优先权日:2015-11-20
标 题 :Heterocyclic compounds that inhibit the kinase activity of Mnk useful for treating various cancers
发明人：SPRENGELER PAUL A; REICH SEIGFRIED H; WEBBER STEPHEN E; ERNST JUSTIN T
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula IA or Formula IB, as well as stereoisomers, tautomers or pharmaceutically acceptable salts thereof. n nFor Formula IA and Formula IB compounds A 1 , A 2 , A 3 , A 4 , W 1 , W 2 , Y, X, R 1 , R 2 , R 3 , R 4a , R 4b , R 5a , R 5b , R 6 , R 7 , R 8 , R 9 , R 9a , R 9b , R 10 and subscript n are as defined in the specification. The inventive Formula IA and Formula IB compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

专利号:US-9370515-B2
优先权日:2013-03-07
标题 :Mixed lineage kinase inhibitors and method of treatments
发明人：GOODFELLOW VAL S; NGUYEN THONG X; RAVULA SATHEESH B; GELBARD HARRIS A
权利人:CALIFIA BIO INC; UNIV ROCHESTER
摘要:Provided herein are imidazopyridine compounds having an inhibitory effect on mixed lineage kinases (MLKs), methods of their synthesis, and methods of their therapeutic. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and pharmaceutical compositions.

专利号:RU-2036924-C1
优先权日:1989-01-31
标题:Method of synthesis of imidazo-(1,2-b)-pyridazine or their salts and imidazo-(1,2-b)-pyridazine derivatives or their salts