CAS: 84793-07-7; (S)-4-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-5-(Tert-Butoxy)-5-Oxopentanoic Acid

相似化合物

109745-15-5 144313-55-3 24277-39-2

上下游产品

CAS号45120-30-7 l-谷氨酸1-叔丁酯 | CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯 | CAS号157108-58-2 (S)-2-(9H-fluor... | CAS号123639-61-2 Fm°C-L-谷氨酸γ苄脂 | CAS号56-86-0 L-谷氨酸 | CAS号102774-86-7 (9H-芴-9-基)甲基 2,... | CAS号115-11-7 2-甲基丙烯 | CAS号45120-30-7 l-谷氨酸1-叔丁酯 | CAS号200616-38-2 Fm°C-glu(osu)-otbu | CAS号1116-22-9 γ-L-谷氨酰-L-谷氨酸 | CAS号73610-81-8 L-Glutamic acid...

芴甲氧羰基-L-谷氨酸-γ-苄脂置于palladium On Activated Charcoal 吡啶,氢气,三氯氧磷体系中,化学反应生成 芴甲氧羰基-L-谷氨酸 1-叔丁酯
参考文献:A Convenient Preparation Of Several N-Linked Glycoamino Acid Building Blocks For Efficient Solid-Phase Synthesis Of Glycopeptides
标题:A Convenient Preparation Of Several N-Linked Glycoamino Acid Building Blocks For Efficient Solid-Phase Synthesis Of Glycopeptides
摘要:本研究提出了一条便捷且产率高的制备多个boc和fmoc保护的n-连接糖肽单体的方法.这些构建单元可用于糖肽或糖肽模拟物的固相合成,通过制备n-连接的十二糖肽ac-(Glyproasn[gal])4-nh2为例,展示了其作为潜在胶原蛋白模拟物的应用.
DOI:10.1039/b201296K

专利信息

专利号:US-2019177392-A1
优先权日:2014-09-23
标 题 :Synthesis of glp-1 peptides
发明人：PENIAS NAVON SHARON; NAVEH SHIRLY; VASILEIOU ZOI; BARLOS KONSTANTINOS
权利人:NOVETIDE LTD
摘要:Disclosed are processes for the synthesis of GLP-1 peptides, such as liraglutide and semaglutide, and a process for purifying liraglutide.

专利号:US-5124478-A
优先权日:1987-12-22
标 题:Acid-labile anchor groups for the synthesis of peptide amides by a solid-phase method
发明人：BREIPOHL GERHARD; KNOLLE JOCHEN; STUEBER WERNER
权利人:HOECHST AG
摘要:The invention relates to new compounds of the formula ##STR1## in which R 1 denotes (C 1 -C 8 )-alkyl, R 2 denotes an amino acid residue which is protected with a urethane protective group which can be eliminated with weak acid or base, or denotes an amino protective group which can be eliminated with weak acid or base, R 3 denotes hydrogen or (C 1 -C 4 )-alkyl, and Y 1 -Y 9 denote identical or different radicals hydrogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy or --O--(CH 2 ) n --COOH (with n=1 to 6), with one of these radicals being --O--(CH 2 ) n --COOH, or Y 1 , Y 2 and Y 5 -Y 9 denote identical or different radicals hydrogen, (C 1 -C 4 )-alkyl or (C 1 -C 4 )-alkoxy, Y 3 denotes hydrogen or (C 1 -C 8 )-alkoxy and Y 4 denotes --(CH 2 ) n --COOH or --NH--CO--(CH 2 ) n --COOH (with n=1 to 6). n Processes for the preparation thereof and the synthesis of peptide amides by a solid-phase method using these new compounds (spacers) are described.

专利号:US-11518794-B2
优先权日:2016-08-19
标 题:Synthesis method for liraglutide with low racemate impurity
发明人：FU YUQING; MA HONGJI; LI XINYU; ZHANG LIXIANG; ZHI QIN; WU LIFEN; LIU ZICHENG
权利人:SHENZHEN JYMED TECH CO LTD
摘要:A synthesis method for low-racemization impurity liraglutide comprises the following steps: performing synthesis to obtain a propeptide, coupling 2 to 5 peptides comprising Thr-Phe on the propeptide by using a solid-phase synthesis method; further, performing solid-phase synthesis to obtain a liraglutide resin; the liraglutide resin is cracked after modification, or the liraglutide resin is directly cracked, purified and frozen dry, so as to obtain the liraglutide. The provided liraglutide synthesis method effectively restrains or reduces the generation of racemization impurity D-Thr 5 highly similar to a product property, which facilitates the purification of the coarse liraglutide, and the high yield of the liraglutide is ensured, thereby greatly reducing production costs; during the synthesis of the liraglutide, the syntheses between dipeptide fragments, tripeptide fragments, the tetrapeptide fragments and pentapeptide fragments and the Gly-resin or the syntheses between the combination of the dipeptide fragments, the tripeptide fragments, the tetrapeptide fragments and pentapeptide fragments and the Gly resin can be carried out at the same time, and accordingly the synthesis time is shortened to some extent.

专利号:US-10344069-B2
优先权日:2014-10-31
标 题:Process for the preparation of liraglutide
发明人：VADLAMANI SURESH KUMAR; DAGADU PATIL NILESH; SHAFEE MOHAMMED ABDUL; PATIL SANJAY DEVIDAS; AGASALADINNI NAGANA GOUD
权利人:AURO PEPTIDES LTD; VADLAMANI SURESH KUMAR; DAGADU PATIL NILESH; SHAFEE MOHAMMED ABDUL; PATIL SANJAY DEVIDAS; AGASALADINNI NAGANA GOUD
摘要:The present invention relates to a process for the preparation of Liraglutide, which comprises: a) synthesis of suitable fragments (protected) by solid phase peptide synthesis; b) coupling of the suitable fragments on solid support; c) concurrently cleaving the protected peptide from the solid support and de-protecting the peptide; d) purification of Liraglutide (crude) on reverse phase HPLC; e) isolating pure Liraglutide.

专利号:US-2015099864-A1
优先权日:2013-10-08
标题:Preparation of organophosphate peptide adducts
发明人：BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T
权利人:BATTELLE MEMORIAL INSTITUTE
摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.

专利号:WO-2015053980-A1
优先权日:2013-10-08
标 题 :Preparation of organophosphate peptide adducts
发明人：BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T
权利人:BATTELLE MEMORIAL INSTITUTE
摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.