= 87199-18-6 反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; -78 °C; 30 Min,-78 °C1.2 Reagents: Triisopropyl Borate; -78 °C; 30 Min,-78 °C; -78 °C -> 0 °C; 1 H,0 °C1.3 Reagents: Hydrochloric Acid Solvents: Water 标题:Photocatalyzed Transition-Metal-Free Oxidative Cross-Coupling Reactions Of Tetraorganoborates 作者:Music,Arif; Et Al 参考文献:Chemistry - A European Journal 日期:2021 卷标:27(13) 页码:4322-4326
3-氨基苯硼酸置于硫酸,Sodium Nitrite体系中,化学反应生成 3-羟基苯硼酸 参考文献:Compositions For Oxidatively Dyeing Keratin Fibers And Methods For Using Such Compositions 标题:Compositions For Oxidatively Dyeing Keratin Fibers And Methods For Using Such Compositions 摘要:用于染色的组合物包括:(A)至少一种选自含有至少一个硼酸或硼酸酯基团的芳香族系统的角蛋白染料化合物,这些化合物在氧化时能够形成亲核物或亲电子物;(B)至少一种额外的角蛋白染料化合物,选自辅助显色剂和辅助偶联剂的组合;(C)一种化妆品适用的介质.氧化染角蛋白纤维的方法包括在氧化剂存在下应用这样的组合物,并冲洗头发.一种套装形式的头发染色产品包括一个第一独立包装容器,其中包含上述描述的组合物,以及一个第二独立包装容器,其中包含氧化剂.
专利号:US-7674876-B2 优先权日:2005-05-25 标题:Synthesis of novel monomers containing the trifluorovinylidene group and the cyanato group and polymers thereof 发明人:DREYER CHRISTIAN; BAUER MONIKA; IYER SURESH S; SMITH DENNIS W 权利人:FRAUNHOFER GES FORSCHUNG; UNIV CLEMSON 摘要:Novel hybrid monomers containing both the aryltrifluorovyinyloxyether-group (TFVE-group) and the cyanato-group, their synthesis, and the synthesis of polymers made from these new hybrid monomers are disclosed.
专利号:US-11401235-B2 优先权日:2015-09-22 标 题 :Synthesis of terphenyl compounds 发明人:KAYE ANTHONY; QUAZI NURUL; FEAST GEORGE; LAKSHMAN MARSHNIL 权利人:VECTUS BIOSYSTEMS LTD 摘要:The present invention relates novel methods of synthesizing terphenyl compounds and in particular to novel methods for the synthesis of a compound of Formula I n nor intermediates thereof.
专利号:US-12275733-B2 优先权日:2016-11-07 标 题:Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders 发明人:GRETZKE DIRK; RITZELER OLAF; HEINELT UWE; WEHNER VOLKMAR; SCHMIDT FRIEDEMANN 权利人:SANOFI SA 摘要:The present invention relates to 8-aryl-substituted and 8-heteroaryl-substituted 9H-pyrido[3,4-b]indoles of the formula (I), in which A, E, G, R1 to R6 and R10 are as defined in the claims, which stimulate chondrogenesis and cartilage matrix synthesis and can be used in the treatment of cartilage disorders and conditions in which a regeneration of damaged cartilage is desired, for example joint diseases such as osteoarthritis. The invention furthermore relates to processes for the synthesis of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.
专利号:US-7300639-B2 优先权日:2002-12-03 标 题:Process for removing metals from liquids 发明人:LIU WANSHENG 权利人:BRISTOL MYERS SQUIBB CO 摘要:A process is provided for removing one or more metals from liquids. Also provided is a process for the synthesis of aP2 inhibiting compounds having the formula (I) n nwherein R 1 , R 2 , R 3 , R 4 , HET, and X-Z are as described herein, which process comprising the step of removing one or more metals from a solution of the compound of formula I or an intermediate or precursor thereof. The processes for removing metal comprise the step of contacting the liquid with a solid extractant comprising a metal-binding functionality.
专利号:US-9744252-B2 优先权日:2011-08-17 标 题:Compounds for binding to the platelet specific glycoprotein IIb/IIIa and their use for imaging of thrombi 发明人:BERGER MARKUS; KRUGER MARTIN; LOHRKE JESSICA; REINHARDT MICHAEL; SIEBENEICHER HOLGER 权利人:PIRAMAL IMAGING SA 摘要:The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein IIb/IIIa antagonists for imaging of thrombi.
专利号:US-2009196912-A1 优先权日:2004-07-30 标 题:Pyridinylamines 发明人:EICKHOFF JAN ELKE; HAFENBRADL DORIS; SCHWAB WILFRIED; COTTON MATTHEW; KIEBL BERT MATTHIAS; ZECH BIRGIT; MULLER STEFAN; HARRIS JOHN; SAVIC VLADIMIR; MACRITCHIE JACKIE 权利人:GPC BOTECH AG 摘要:Described are pyridinylamines and pharmaceutically acceptable salts thereof, the use of these pyridinylamines for the prophylaxis and/or treatment of various diseases such as infectious diseases, including opportunistic infections, prion diseases immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as pharmaceutical compositions containing at least one pyridinylamine and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the pyridinylamines are disclosed.
参考标题:Design And Synthesis Of Novel, Potent And Selective Hypoxanthine Analogs As Adenosine A 1 Receptor Antagonists And Their Biological Evaluation 作者:Summon Koul,Vidya Ramdas,Dinesh A. Barawkar,Yogesh B. Waman,Neela Prasad,Santosh Kumar Madadi,Yogesh D. Shejul,Rajesh Bonagiri,Sujay Basu,Suraj Menon,Srinivasa B. Reddy,Sandhya Chaturvedi,Srinivas Rao Chennamaneni,Gaurav Bedse,Rhishikesh Thakare,Jayasagar Gundu,Sumit Chaudhary,Siddhartha De,Ashwinkumar V. Meru,Venkata Palle,Anita Chugh,Kasim A. Mookhtiar |发布日期:2017.3 摘要:Multipronged Approach Was Used To Synthesize A Library Of Diverse C-8 Cyclopentyl Hypoxanthine Analogs From A Common Intermediate Iii. Several Potent And Selective Compounds Were Identified And Evaluated For Pharmacokinetic (Pk) Properties In Wistar Rats. One Of The Compounds 14 With Acceptable Pk Parameters Was Selected For Testing In In Vivo Primary Acute Diuresis Model. The Compound Demonstrated
合成参考文献
摘要:Guram, A. S.; Milne, J. E.; Tedrow, J. S.; Walker, S. D., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 140.