CAS: 11015-37-5; Bambermycin

专利信息

专利号:US-2001049117-A1
优先权日:1998-08-20
标 题 :Analogs of udp-murnac peptides, assays, kits and related methods of their use
发明人：AXELROD HELENA R; BRANSTROM ARTHUR A
摘要:General compositions and methods for detecting Lipid I, Lipid II and peptidoglycan synthesis is disclosed. A method of screening for potential antibacterial agents is provided which requires bacterial membrane preparations or enriched enzyme preparations including at least one bacterial enzyme involved in the synthesis of Lipid I from UDP-MurNAc pentapeptide and undecaprenyl phosphate, at least one bacterial enzyme involved in the synthesis of Lipid II from Lipid I and UDP-GlcNAc and one or more bacterial enzymes involved in the further processing of Lipid II toward the downstream synthesis of peptidoglycan. The methods disclosed herein further provides a labeled UDP-MurNAc-peptide capable of serving as a substrate for a bacterial enzyme involved in the synthesis of Lipid I and a labeled UDP-GlcNAc capable of serving as a substrate for a bacterial enzyme involved in the synthesis of Lipid II. Conditions for further processing of Lipid II toward the downstream synthesis of peptidoglycan are also discribed.

专利号:US-9693999-B2
优先权日:2011-01-26
标题:Small molecule RNase inhibitors and methods of use
发明人：DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE
权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education
摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

专利号:US-9115358-B2
优先权日:2006-08-11
标题 :Moenomycin biosynthesis-related compositions and methods of use thereof
发明人：WALKER SUZANNE; OMELYANOVICH OSTASH BOHDAN
权利人:WALKER SUZANNE; OMELYANOVICH OSTASH BOHDAN; HARVARD COLLEGE
摘要:The methods and compositions described herein relate to the identification, isolation, and characterization of genes which encode proteins useful for the biosynthesis of transglycosylase inhibitors such as moes. The methods and compositions also relate to the production of such proteins, and their use in the synthesis of moes, the expression of moes, and the production of modified moes.

专利号:US-5079154-A
优先权日:1988-03-30
标 题:Mutant resistant to cell membrane synthesis inhibitor and process for preparing the same
发明人：ITO SUSUMU; SHIMOOKA MASAHARU; OHTA YUICHI; TAKAIWA MIKIO; ADACHI SHIGEHITO
权利人:KAO CORP
摘要:A mutant of an extracellular enzyme-producing microorganism belonging to genus Bacillus, which is resistant to a cell membrane synthesis inhibitor, including vancomycin and ristocetin, is disclosed. The cell membrane synthesis inhibitor-resistant mutant can produce such an enzyme as cellulase, protease, or amylase about 2 to 4 times of the parent strain. Such a mutant can be produced by subjecting an extracellular enzyme-producing microorganism tot a mutation treatment, and culturing said microorganism in a culture medium containing a cell membrane synthesis inhibitor.

专利号:US-6955886-B1
优先权日:1998-05-15
标题:Scintillation proximity assay for the detection of peptidoglycan synthesis
发明人：DESOUSA SUNITA; PRAHLAD DWARAKANATH
权利人:ASTRAZENECA AB
摘要:The invention provides a scintillation proximity assay for detecting peptidoglycan synthesis. The assay is especially suitable for high throughput screening of compounds affecting peptidoglycan synthesis.

专利号:US-8604004-B2
优先权日:2007-10-04
标 题 :Moenomycin analogs, methods of synthesis, and uses thereof
发明人：KAHNE DANIEL; KAHNE SUZANNE WALKER; ADACHI MASAATSU; DOUD EMMA; FUSE SHINICHIRO; LIN XIAONAN; ZHANG YI; TSUKAMOTO HIROKAZU; OSTASH BOHDAN
权利人:KAHNE DANIEL; KAHNE SUZANNE WALKER; ADACHI MASAATSU; DOUD EMMA; FUSE SHINICHIRO; LIN XIAONAN; ZHANG YI; TSUKAMOTO HIROKAZU; OSTASH BOHDAN; HARVARD COLLEGE
摘要:The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an inventive compound to a subject in need thereof. The moenomycin analogs may be prepared synthetically, biosynthetically, or semi-synthetically. The analogs are particularly useful in treating or preventing infections caused by Gram-positive organisms. Certain inventive compounds may have a broader spectrum of coverage, which includes Gram-negative organisms.