CAS: 1231929-97-7; N-(5-((4-Ethylpiperazin-1-yl)Methyl)Pyridin-2-yl)-5-Fluoro-4-(4-Fluoro-1-Isopropyl-2-Methyl-1H-Benzo[d]Imidazol-6-yl)Pyrimidin-2-Amine

上下游产品

6-(2-氯-5-氟-嘧啶-4-基)-4-氟-1-异丙基-2-甲基-1H-苯并咪唑 6-(2-Chloro-5-Fluoropyrimidin-4-yl)-4-Fluoro-1-Isopropyl-2-Methyl-1H-Benzo[d]Imidazole 1231930-42-9
6-溴-4-氟-1-异丙基-2-甲基-1H-苯并[d]咪唑 6-Bromo-4-Fluoro-1-Isopropyl-2-Methyl-1H-Benzo[d]Imidazole 1231930-33-8

1-(6-溴吡啶-3-基甲基)-4-乙基哌嗪置于tris-(Dibenzylideneacetone)Dipalladium(0),氨,Caesium Carbonate,4,5-双二苯基膦-9,9-二甲基氧杂蒽体系中,用 1,4-二氧六环,甲醇 用作溶剂,化学反应 2.0H,反应生成玻玛西尼
参考文献: Combination Therapy For Cancer[fr] Polythérapie Contre Le Cancer
标题: Combination Therapy For Cancer[fr] Polythérapie Contre Le Cancer
摘要:本发明提供了用于治疗和治疗非小细胞肺癌的药物制剂的制备以及治疗方法,包括:[5-(4-乙基哌嗪-1-基甲基)-吡啶-2-基]-[5-氟-4-(7-氟-3-异丙基-2-甲基-3H-苯并咪唑-5-基)-嘧啶-2-基]-胺,或其药学上可接受的盐,与抗vegfr2抗体结合,最好是拉姆西单抗.

专利信息

专利号:US-11873305-B2
优先权日:2020-06-30
标题 :Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds
发明人：ZHANG HAIMING; XU JIE; WUITSCHIK GEORG; ANGELAUD REMY; HEROLD SEBASTIAN; STUTZ ALFRED; BRUETSCH TOBIAS; BURKHARD JOHANNES
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:WO-2024199465-A1
优先权日:2023-03-30
标 题:Unnatural amino acid in cellulo synthesis for site-specific protein modification
发明人：CHAN MICHAEL KENNETH; LEE MARIANNE; CHENG JIAHUI
权利人:UNIV HONG KONG CHINESE
摘要:Provided are genetically modified host cells containing engineered enzymes that support the synthesis of unnatural amino acids, such as D-Cys-ε-Lys, and the incorporation of such unnatural amino acids into a newly synthesized protein. These cells are therefore capable of in vivo or in cellulo synthesis of a protein containing one or more unnatural amino acids strategically placed at pre-determined locations for site-specific modification of the protein. Also provided are the corresponding methods for in vivo synthesis of modified proteins as well as the modified proteins produced by the method.

专利号:US-12043612-B2
优先权日:2020-05-09
标 题 :Methods of manufacturing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms comprising the same
发明人：ALLAN LAURA E N; CHEN CHUNGPIN HERMAN; DONG HANQING; GROSSO JOHN A; HASKELL III ROYAL J; LLOYD RHYS; REECE HAYLEY
权利人:ARVINAS OPERATIONS INC
摘要:The present disclosure relates to ultra-pure forms, polymorphs, amorphous forms, and formulations of N-[(1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-({4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}methyl)piperidin-1-yl]pyridazine-3-carboxamide, referred to herein as Compound A:The present disclosure also relates methods of manufacturing and purifying the same, as well as intermediates useful in the synthesis of Compound A. The ultra-pure forms, polymorphs, amorphous forms, and formulations of Compound A can be used as therapeutic agents for the treatment of various diseases and conditions such as cancer.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2022118094-A1
优先权日:2019-02-21
标题:Synthesis of biomimetic cell wall structure
发明人：WANG YONG; SHI PENG
权利人:PENN STATE RES FOUND
摘要:The present invention relates generally to methods of generating a biomimetic cell wall (BCW) on a target surface, compositions comprising the BCW, and methods of use of the compositions, including biomedical applications of the BCW coated compositions.