CAS: 1350653-20-1; Methyl (4,6-Diamino-2-(5-Fluoro-1-(2-Fluorobenzyl)-1H-Pyrazolo[3,4-B]Pyridin-3-yl)Pyrimidin-5-yl)Carbamate

上下游产品

2,6-dichloro-5-fluoropyridine-3-carboxamide 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine methyl chloroformate 2,6-dichloro-5-fluoro-pyridine-3-carbonitrilemethyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}(2,2,2-trifluoroethyl)carbamate methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate maleate methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate mesylate

2-[5-Fluoro-1-(2-Fluorobenzyl)-1H-Pyrazolo[3,4-B]Pyridin-3-Yl]-5-Nitropyrimidine-4,6-Diamine置于palladium 10% On Activated Carbon 吡啶,氢气体系中,用 二氯甲烷 用作溶剂,化学反应 1.0H,反应生成维利西呱
参考文献: The Use Of Sgc Stimulators,Sgc Activators,Alone And Combinations With Pde5 Inhibitors For The Treatment Of Systemic Sclerosis (Ssc).[fr] Utilisation De Stimulateurs De La Sgc,D'Activateurs De La Sgc,Seuls Et En Association Avec Des Inhibiteurs De La Pde5 En Vue Du Traitement De La Sclérodermie Systémique
标题: The Use Of Sgc Stimulators,Sgc Activators,Alone And Combinations With Pde5 Inhibitors For The Treatment Of Systemic Sclerosis (Ssc).[fr] Utilisation De Stimulateurs De La Sgc,D'Activateurs De La Sgc,Seuls Et En Association Avec Des Inhibiteurs De La Pde5 En Vue Du Traitement De La Sclérodermie Systémique
摘要:使用sgc刺激剂,单独使用sgc激活剂,或与pde5抑制剂结合,用于预防和治疗纤维化疾病,如系统性硬化症,硬皮病以及内脏器官的同时纤维化.

专利信息

专利号:EP-4519262-A1
优先权日:2022-05-03
标题 :2-(5-fluoro-1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl)-5-nitrosopyrimidin-4,6-diamine or a salt thereof, method for the preparation thereof, and use thereof in the synthesis of vericiguat

专利号:WO-2023213525-A1
优先权日:2022-05-03
标 题:2-(5-FLUORO-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-b]PYRIDIN-3-YL)-5-NITROSOPYRIMIDIN-4,6-DIAMINE OR A SALT THEREOF, METHOD FOR THE PREPARATION THEREOF, AND USE THEREOF IN THE SYNTHESIS OF VERICIGUAT

专利号:US-2025276969-A1
优先权日:2022-05-03
标 题 :2-(5-FLUORO-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-b]PYRIDIN-3-YL)-5-NITROSOPYRIMIDIN-4,6-DIAMINE OR A SALT THEREOF, METHOD FOR THE PREPARATION THEREOF, AND USE THEREOF IN THE SYNTHESIS OF VERICIGUAT