2-氯乙酰乙酸乙酯置于氢氟酸,三乙胺体系中,用 乙腈 用作溶剂,化学反应生成2-氟乙酰乙酸乙酯 参考文献:Process For The Preparation Of .Alpha.-Fluoro-.Beta.-Dicarbonyl Compounds 标题:Process For The Preparation Of .Alpha.-Fluoro-.Beta.-Dicarbonyl Compounds 摘要:.Alpha.-氟-.Beta.-二羰基化合物是通过将卤代二羰基化合物与氟化氢和三烷基胺的加成产物在20oc至100oc的温度下反应制备的.这个过程在技术上很容易实施,也可以大规模进行.
专利号:US-2009137557-A1 优先权日:2005-11-22 标题 :Calcilytic Compounds 发明人:KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S 权利人:KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S 摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.
专利号:US-2005113397-A1 优先权日:2002-01-31 标题:Imidazo[1,2-a]pyridine derivative 发明人:TAKEMURA MAKOTO; TAKAHASHI HISASHI; KAWAKAMI KATSUHIRO; TAKESHITA HIROSHI; KIMURA YOUICHI; WATANABE JUN; SUGIMOTO YUICHI; KITAMURA AKIHIRO; NAKAJIMA RYOHEI; KANAI KAZUO; FUJISAWA TETSUNORI 摘要:A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.
专利号:CN-105061338-A 优先权日:2014-11-20 标题:A kind of chemical synthesis method of 3-methyl-quinoxaline-2-carboxylic acid based on ionic liquid system
专利号:US-9199945-B2 优先权日:2013-06-21 标题:Cycloalkyl-substituted pyrimidinedione compounds 发明人:OSLOB JOHAN; ANDERSON ROBERT; AUBELE DANIELLE; EVANCHIK MARC; FOX JONATHAN CHARLES; KANE BRIAN; MCDOWELL ROBERT; RODRIGUEZ HECTOR; SONG YONGHONG; SRAN ARVINDER; LU PU-PING 权利人:MYOKARDIA INC 摘要:The present invention provides novel cycloalkyl-substituted pyrimidine dione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.