CAS: 219967-69-8; Fmoc-ß-Homotyr(Tbu)-Oh

相似化合物

1233495-02-7 1352435-52-9 1421258-65-2

上下游产品

CAS号71989-38-3 Fm°C-O-叔丁基-L-酪氨酸

(S)-4-<(4-Tert-Butoxy)Phenyl>-1-Diazo-3-(<<(9H-Fluoren-9-yl)Methoxy>Carbonyl>Amino)Butan-2-One置于n-甲基吗啉,水,Silver Trifluoroacetate体系中,用 四氢呋喃 用作溶剂,化学反应 4.0H,以74%的收率获得o-叔丁基-N-Fmoc-L-β-高酪氨酸
参考文献:(S)-β3-Homolysine-And (S)-β3-Homoserine-Containingβ-Peptides: Cd Spectra In Aqueous Solution
标题:(S)-β3-Homolysine-And (S)-β3-Homoserine-Containingβ-Peptides: Cd Spectra In Aqueous Solution
摘要:For Further Structural Studies And For Physiological Investigations Of Beta-Peptides,It Is Necessary To Have H2O-Soluble Derivatives. Thus,We Have Prepared Beta-Hexa-,Beta-Hepta-,And Beta-Nonapeptides (1-6) With Two,Three,And Seven Side Chains Of Lysine And Serine. To Detect Possible Pi-Pi Interactions,We Also Included The Beta-Amino Acid Beta(2)-Hhop,Resulting From Homologation Of So-Called Homophenylalanine (Hop) (5 And 6). The Fmoc-Beta(2)-And Beta(3)-Amino-Acid Derivatives (11-14 And 19),And The Corresponding Beta-Peptides Were Prepared By Methods Previously Described (Solid-Phase Peptide Coupling; HPLC-Pure Samples,Fig. I). Circular-Dichroism Spectra (Fig.2) Indicate The Presence Of Less Pronounced Secondary Structures (Especially Of The Lysine Analogues With Multiple Positive Charge) In H2O As Compared To Meoh. The Beta(3)-Heptapeptide (3) With Two Serine Side Chains Is Well Soluble In H2O And Exhibits The Cd Pattern Typical Of The 3(1)-Helical Structure.
Doi:10.1002/(Sici)1522-2675(19981216)81:12<2141::Aid-Hlca2141>3.0.Co;2-5