专利号:US-12338202-B2 优先权日:2021-09-10 标 题 :One pot synthesis of urea (meth)acrylates 发明人:BESTGEN SEBASTIAN; BEYER SILVIA 权利人:EVONIK OPERATIONS GMBH 摘要:A one-pot synthesis of polymerizable and acyclic urea (meth)acrylates, preferably mono(meth)acrylates, can be performed via in-situ synthesis of urea alcohols or amines followed by direct reaction with a (meth)acrylate reactive diluent. The urea alcohol/amine is obtained from isocyanates and alcohols, amines, or hydroxyamines. Subsequently, the reaction with the (meth)acrylate reactive diluent takes place and the urea (meth)acrylate is directly obtained either in solution with the reactive diluent, or as a pure material after removal of the reactive diluent.
专利号:US-6329543-B1 优先权日:1999-05-06 标题:Process for synthesis of isobornyl (Meth) acrylate 发明人:KNEBEL JOACHIM; SAAL DORIS 权利人:ROEHM GMBH 摘要:The present invention relates to processes for synthesis of isobornyl (meth)acrylate by reacting camphene with (meth)acrylic acid in the presence of sulfuric acid and at least one compound having inhibiting action. Aqueous sulfuric acid with an acid concentration in the range of 65 to 85 wt % is used. Isobornyl (meth)acrylate can advantageously be distilled from a mixture containing sulfuric acid in the presence of 2,6-di-tert-butyl-alpha-(dialkylamino)-p-cresol.
专利号:WO-2005100367-A1 优先权日:2004-04-13 标 题 :Intermediates useful in the synthesis of 3-(2-substituted vinyl) cephalosporins 发明人:KUMAR YATENDRA; PRASAD MOHAN; SINGH KAPTAN; PRASAD ASHOK; RICHHARIYA SANTOSH 权利人:RANBAXY LAB LTD; KUMAR YATENDRA; PRASAD MOHAN; SINGH KAPTAN; PRASAD ASHOK; RICHHARIYA SANTOSH 摘要:The present invention relates to crystalline intermediates useful in the synthesis of 3-(2-substituted vinyl) cephalosporins and processes for their preparation. In particular, the present invention relates to crystalline ylides of Formula I, processes for their preparation, and their use as an intermediate in thepreparation of 3-(2-substituted vinyl) cephalosporins.
专利号:US-3674818-A 优先权日:1969-12-05 标 题:Synthesis of a material with juvenile hormone activity 发明人:LAW JOHN H 权利人:US HEALTH EDUCATION & WELFARE 摘要:Synthesis of a material with juvenile hormone activity by reacting crude or purified farnesoic acid with alcoholic hydrogen chloride wherein the alcohol is selected from the group consisting of ethanol, methanol, n-propanol and n-pentanol. Various comparisons are shown with other related compounds and an exemplary list of insects sensitive to the material is set forth.
专利号:US-7592392-B2 优先权日:2003-04-04 标 题 :Synthesis of functional polymers for use in organic synthesis and combinatorial chemistry 发明人:LINDSLEY CRAIG W; WISNOSKI DAVID D 权利人:MERCK & CO INC 摘要:The present invention relates to a novel process for the preparation of solid-supported scavenging reagents and solid-supported functional polymers. The invention further relates to novel solid-supported functional polymers and to their use in organic synthesis and combinatorial chemistry.
专利号:US-2008287407-A1 优先权日:2003-12-10 标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use 发明人:GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI 权利人:NITROMED INC 摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.
1: Li T, Zhang T, Gao H, Liu R, Gu M, Yang Y, Cui T, Lu Z, Yin C. Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction. Redox Biol. 2021 May;41:101886. doi: 10.1016/j.redox.2021.101886. Epub 2021 Feb 3. 2: Rossetto I, Santos F, Kido L, Lamas C, Montico F, Cagnon V. Tempol differential effect on prostate cancer inflammation: In vitro and in vivo evaluation. Prostate. 2023 Apr;83(5):403-415. doi: 10.1002/pros.24473. Epub 2022 Dec 22. 101(6):289-297. doi: 10.1111/iep.12376. Epub 2020 Oct 24. 4: Hermes TA, Mâncio RD, Macedo AB, Mizobuti DS, Rocha GLD, Cagnon VHA, Minatel E. Tempol treatment shows phenotype improvement in mdx mice. PLoS One. 2019 Apr 22;14(4):e0215590. doi: 10.1371/journal.pone.0215590.
合成参考文献
参考文献:10.3109/10611861003639796 摘要:Carroll RT, Bhatia D, Geldenhuys W, Bhatia R, Miladore N, Bishayee A, Sutariya V. Brain-targeted delivery of Tempol-loaded nanoparticles for neurological disorders. J Drug Target. 2010 Nov;18(9):665–74. doi: 10.3109/10611861003639796. 参考文献:10.1042/bj20110555 摘要:Queiroz RF, Vaz SM, Augusto O. Inhibition of the chlorinating activity of myeloperoxidase by tempol: revisiting the kinetics and mechanisms. Biochem J. 2011 Nov 01;439(3):423–31. doi: 10.1042/bj20110555. 参考文献:10.1161/01.atv.0000198399.40584.8c 摘要:Hatoum OA, Otterson MF, Kopelman D, Miura H, Sukhotnik I, Larsen BT, Selle RM, Moulder JE, Gutterman DD. Radiation induces endothelial dysfunction in murine intestinal arterioles via enhanced production of reactive oxygen species. Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):287–94. doi: 10.1161/01.atv.0000198399.40584.8c. 参考文献:10.1111/j.1476-5381.2011.01437.x 摘要:Xiao D, Huang X, Yang S, Zhang L. Antenatal nicotine induces heightened oxidative stress and vascular dysfunction in rat offspring. Br J Pharmacol. 2011 Nov;164(5):1400–9.