专利号:US-2016194279-A1 优先权日:2012-12-09 标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas 发明人:CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR 权利人:COUNCIL SCIENT IND RES 摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.
专利号:EP-0479161-A1 优先权日:1990-10-01 标题:Synthesis of heterocyclic compounds 发明人:PERRY ROBERT JAMES 权利人:EASTMAN KODAK CO 摘要:A new synthetic method is reported in which 2-arylbenz(ox,imid,thi)azoles can be prepared by the palladium catalyzed condensation of aromatic halides with o-amino(phenol, aniline, thiophenol)s followed by dehydrative cyclization. This method is tolerant of a wide variety of functional groups on either aromatic ring and gives good to excellent yields of products.
专利号:WO-2010048514-A1 优先权日:2008-10-23 标题:Synthesis of 2-aminobenzoxazole compounds
专利号:CA-2051518-A1 优先权日:1990-10-01 标 题 :Synthesis of heterocyclic compounds
专利号:WO-2024126786-A1 优先权日:2022-12-15 标 题 :Process for preparing allylic alcohol 发明人:BONOMO LUCIA; JACOBY DENIS; ARBICHA PASCAL; FONTENY FABIEN; KELLER FABRICE 权利人:FIRMENICH & CIE 摘要:The present invention relates to the field of organic synthesis and more specifically it concerns a process for the rearrangement of epoxides into allylic alcohols in a presence of zinc catalyst and two amino phenol.
专利号:US-12152038-B2 优先权日:2017-09-05 标 题:Vasopressin receptor antagonists and products and methods related thereto 发明人:JONES ROBERT M; URBANO MARIANGELA; BRANDT GARY; CHAMBERS MARK; HARDICK DAVID; KNIGHT CHRIS; TIERNEY JASON; LOCK CHRIS 权利人:NEUMORA THERAPEUTICS INC 摘要:Compounds are provided that antagonize vasopressin receptors, particularly the V1a receptor products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof:wherein Q1, Q2, Q3, R2a, R2b, R3 and X are as defined herein.
[参考文献]: A Schenzle, Et Al. Chemoselective Nitro Group Reduction And Reductive Dechlorination Initiate Degradation Of 2-Chloro-5-Nitrophenol By Ralstonia Eutropha Jmp134. Appl Environ Microbiol. 1999 Jun;65(6):2317-23. [参考文献]: E Katsivela, Et Al. Initial Reactions In The Biodegradation Of 1-Chloro-4-Nitrobenzene By A Newly Isolated Bacterium, Strain Lw1. Appl Environ Microbiol. 1999 Apr;65(4):1405-12. [参考文献]: G O Rankin, Et Al. Nephrotoxic Potential Of 2-Amino-5-Chlorophenol And 4-Amino-3-Chlorophenol In Fischer 344 Rats: Comparisons With 2- And 4-Chloroaniline And 2- And 4-Aminophenol. Toxicology. 1996 Apr 15;108(1-2):109-23. [参考文献]: Jian-Feng Wu, Et Al. Novel Partial Reductive Pathway For 4-Chloronitrobenzene And Nitrobenzene Degradation In Comamonas Sp. Strain Cnb-1. Appl Environ Microbiol. 2006 Mar;72(3):1759-65. [参考文献]: M Valentovic, Et Al. 2-Amino-5-Chlorophenol Toxicity In Renal Cortical Slices From Fischer 344 Rats: Effect Of Antioxidants And Sulfhydryl Agents. Toxicol Appl Pharmacol. 1999 Nov 15;161(1):1-9.
合成参考文献
参考文献:10.1006/taap.1999.8784 摘要:Valentovic M, Meadows MK, Harmon RC, Ball JG, Hong SK, Rankin GO. 2-Amino-5-chlorophenol toxicity in renal cortical slices from Fischer 344 rats: effect of antioxidants and sulfhydryl agents. Toxicol Appl Pharmacol. 1999 Nov 15;161(1):1–9. doi: 10.1006/taap.1999.8784.