专利号:US-3953416-A 优先权日:1971-12-20 标 题:Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same 发明人:FOLKERS KARL; CURRIE BRUCE L; CHANG JAW-KANG; SIEVERTSSON HANS; BOGENTOFT CONNY 权利人:FOLKERS KARL; CURRIE BRUCE L; CHANG JAW KANG; SIEVERTSSON HANS; BOGENTOFT CONNY 摘要:A synthetic decapeptide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide which has the hormonal activities of the luteinizing hormone releasing hormone (LRH) of the hypothalamus gland of mammals is produced by utilizing as the key starting materials, the amino acids, glutamic acid or pyroglutamic acid, histidine, tryptophan, serine, tyrosine, glycine, leucine, arginine, and proline. Synthesis of the decapeptide is accomplished by coupling, in appropriate combinations of appropriate protected forms of the amino acids, and finally deprotecting to yield the amide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide.
专利号:US-3787385-A 优先权日:1971-05-17 标 题 :Synthetically produced tetrapeptide having the activity of the luteinizing hormone releasing hormone 发明人:CHANG J; SIEVERTSSON H; FOLKERS K 权利人:FOLKERS K; CHANG J; SIEVERTSSON H 摘要:A NEW TETRAPEPTIDE, L-P-GLUTAMYL-L-TYROSYL-L-ARAGINYLL-TYRPTOPHAN AMIDE, HAVING THE HORMONAL ACTIVITY OF THE LUTEINIZING HORMONE RELEASING HORMONE (LRH) OF THE HYPOTHALAMUS GLAND OF MAMMALS IS PROVIDED BY UTILIIZING AS KEY STARTING MATERIALS, THE AMINO ACIDS, GLUTAMIC ACID, TYROSINE, ARGININE, AND TRYPTOPHAN. SYNTHESIS OF THE NEW TETRAPEPTIDE, IS ACCOMPLISHED BY COUPLING, IN APPROPRIATE FREE OR PROTECTED FORMS, ANY COMBINATION OF THESE FOUR AMINO ACIDS TO OBTAIN THE L-P-GLUTAMYL-L-TYROSYL-LARGINYYL-;-TRYPTOPHAN AMIDE.
专利号:US-6849701-B2 优先权日:2001-03-02 标 题:Droplet polymerization method for synthesis of molecularly imprinted polymers 发明人:NORTON TUCKER 权利人:DU PONT 摘要:A droplet polymerization process is provided to create efficacious molecularly imprinted polymers (MIPs). Such imprinted polymers have increased surface area for adsorptive or catalytic reactions. This method provides for monomer-template interactions in the absence of a suspending medium, thereby permitting formation of MIPs with increased template selectivity and substantial processing advantages. The process is particularly useful for separating isoflavones from soy whey.
专利号:US-9422306-B2 优先权日:2012-12-21 标题:Artemisinin compounds and synthesis and use thereof 发明人:SASAKI TOMIKAZU; WANG SHUSHENG 权利人:UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION 摘要:The present disclosure describes artemisinin compounds. The compounds can be synthesized using an Ugi synthesis reaction and can be used in the treatment of cancers, parasitic infections and yeast infections.
专利号:US-11529370-B2 优先权日:2017-11-24 标 题 :Use of composition comprising stem cell-derived exosome as effective ingredient in strengthening skin barrier and improving skin barrier function 发明人:YI YONG WEON; CHO BYONG SEUNG 权利人:EXOCOBIO INC 摘要:A composition for strengthening skin barrier or improving skin barrier function is able to improve objective indicators related to the protection of skin barrier, the strengthening of skin barrier, and/or the improvement of skin barrier function. The composition exhibits the effects of increasing the amount of ceramides, dihydroceramides and sphingoid bases, increasing the activities of enzymes that are involved in the synthesis thereof, and decreasing the activities of enzymes that are involved in the degradation thereof. In addition, the composition is able to restore skin barrier function by reducing TSLP, IL-4, and IL-13 which are closely associated with skin barrier damage, and thus interrupting a vicious circle in which the lipids and proteins contributing to skin barrier decrease.
专利号:US-6150403-A 优先权日:1997-10-14 标 题 :Topical compositions for regulating the oily/shiny appearance of skin 发明人:BIEDERMANN KIMBERLY A; SCHUBERT HARRY L; PARRAN JR JOHN J 权利人:PROCTER & GAMBLE 摘要:The present invention relates to methods for inhibiting sebaceous gland activity in mammalian skin comprising administration of a topical composition comprising dehydroacetic acid or pharmaceutically acceptable salts thereof, and a dermatologically-acceptable carrier. The present invention also relates to methods and topical compositions further comprising agents which regulate the oily and/or shiny appearance of skin, and agents which treat acne and related skin disorders in mammalian skin and scalp. Methods of reducing sebum synthesis with the use of dehydroacetic acid, methods of regulating the oily and/or shiny appearance of skin, and methods of treating acne and other skin disorders are also encompassed by the present invention.
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合成参考文献
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