CAS: 551-68-8; (3R,4R,5R)-1,3,4,5,6-Pentahydroxyhexan-2-One

化学文摘社编号551-68-8,被归类为氯己exose,结构上类似于fructose,在某些水果和食品中发现数量很少.D-Psicose以低热量含量为显著特征,每克约提供0.2至0.4卡路里,使它成为减少热量摄入量的有吸引力的替代甜食者.它与苏格罗斯相似,但具有显著较低的糖分指数,这意味着它对血糖含量的影响最小.D-Picose也因其潜在的健康利益而得到承认,包括促进脂肪代谢性的能力和增加胰岛素的敏感性.在溶液方面,它溶解度很高,因此很容易融入各种食品和饮料配方.

结构式图片

相似化合物

17598-82-2 57-48-7 87-79-6

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CAS号79-14-1 羟基乙酸 | CAS号849585-22-4 2-羟基丙酸 | CAS号57-48-7 果糖 | CAS号3458-28-4 D-甘露糖 | CAS号50-99-7 D(+)-无水葡萄糖 | CAS号64-19-7 冰醋酸

合成工艺路线路线简述

    D-阿洛糖置于吡啶体系中,化学反应生成 D-阿洛酮糖
    参考文献:D-蔗糖
    标题:D-蔗糖
    摘要:
    DOI:10.1002/hlca.19360190129

    海关参考信息

    专利信息


    专利号:US-2019315790-A1
    优先权日:2016-11-11
    标题:Synthesis of d-allulose
    发明人:KOCH TIMO JOHANNES; KIPPING FLORIAN; BUTZ STEFFEN; LESCH MARCEL; HÄSSLER THOMAS
    权利人:PFEIFER & LANGEN GMBH & CO KG
    摘要:The invention relates to a process for the synthesis of a product saccharide, preferably of D-allulose from an educt saccharide, preferably from D-fructose under heterogeneous or homogeneous catalysis which includes chemical and/or enzymatic catalysis. The synthesis is performed in at least two reactors that are arranged in series and the reaction product exiting the first reactor is subjected to chromatographic separation before it enters the second reactor. Preferably, the chromatographic separation is integrated in a simulated moving bed.

    专利号:US-5945529-A
    优先权日:1996-07-19
    标题:Synthesis of polyol fatty acid polyesters using column with inert gas stripping
    发明人:CORRIGAN PATRICK JOSEPH; KENNEALLY COREY JAMES; GRANBERG ERIC PAUL
    权利人:PROCTER & GAMBLE
    摘要:Processes for the synthesis of polyol fatty acid polyester by transesterification of a polyol comprise reacting polyol with a first portion of fatty acid lower alkyl ester to provide a first step reaction product in which substantially all of the polyol is reacted with at least one fatty acid lower alkyl ester. The processes then employ a multistage column providing substantial plug flow of liquid therein for further transesterification of the first step reaction product. Partially esterified polyol, a second portion of fatty acid lower alkyl ester and catalyst are fed to the column to form a mixture and cause further transesterification of the partially esterified polyol and fatty acid lower alkyl ester, with lower alkyl alcohol being formed as a by product. The resulting liquid mixture of reactants and product is passed in a first direction between adjacent stages through the column for further reaction of partially esterified polyol with fatty acid lower alkyl ester. An inert stripping or sparging gas is fed through the column in a second direction between adjacent stages, counter current to the flow of the liquid mixture between adjacent stages in the first direction, with radial shear agitation. The lower alkyl alcohol by-product of the polyol-fatty acid lower alkyl ester reaction is transferred from the liquid mixture to the inert gas.

    专利号:US-10973847-B2
    优先权日:2017-06-30
    标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof
    发明人:JOHNSON JEREMIAH A; GOLDER MATTHEW R
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.

    专利号:US-7557099-B2
    优先权日:2004-03-01
    标题 :Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines
    发明人:HOWARD PHILIP WILSON; KANG GYOUNG-DONG
    权利人:SPIROGEN LTD
    摘要:Compounds and a method of synthesis of compounds of formula (Ia) or (Ib): and salts, solvates, and chemically protected forms thereof, wherein the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R 2 and R 3 are independently selected from —H, â•?O, â•?CH 2 , —CN, —R, OR, halo, â•?CH—R, O—SO 2 —R, CO 2 R and COR; R 10 is a carbamate-based nitrogen protecting group; and R 11 is an oxygen protecting group.

    专利号:US-8183355-B2
    优先权日:2006-04-28
    标题 :Method for the synthesis of oligonucleotide derivatives
    发明人:MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE
    权利人:MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE; CENTRE NAT RECH SCIENT
    摘要:Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistryâ€? reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. n Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting.

    专利号:US-9783517-B2
    优先权日:2010-08-19
    标题 :Method for synthesis of an output including diesters of 5-methyl-2-furoic acid
    发明人:CAHANA AVIAD; MARTIN TIM
    权利人:CAHANA AVIAD; MARTIN TIM; XF TECH INC
    摘要:The present invention describes methods and apparatuses for the synthesis of 5-(chloromethyl)-2-furaldehyde (CMF) from saccharides in pure or crude form, the method comprising: (a) continuously contacting saccharides in pure or crude form, hydrochloric acid, and an organic solvent, by way of a continuous, biphasic-flow reactor assembly at a temperature from about 60 degrees C. to about 200 degrees C. and pressures from about 1 atmosphere to about 20 atmospheres, such that CMF is produced; (b) separating 5-(chloromethyl)-2-furaldehyde by liquid/liquid and solid/liquid phase separation; (c) producing at least five kilograms per day with at least 50% yield. Embodiments of the present invention can produce CMF in a continuous fashion, with high yield and without degradation of CMF to such side products as 5-(hydroxymethyl)furfural (HMF), 2-(2-hydroxyacetyl)furan (HAF) and levulinic acid (LA).
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    主要参考文献

    [参考文献]: Andreas Bosshart, Et Al. Directed Divergent Evolution Of A Thermostable D-Tagatose Epimerase Towards Improved Activity For Two Hexose Substrates. Chembiochem. 2015 Mar 2;16(4):592-601.
    [参考文献]: Anna Lluveras-Tenorio, Et Al. Analysis Of Plant Gums And Saccharide Materials In Paint Samples: Comparison Of Gc-Ms Analytical Procedures And Databases. Chem Cent J. 2012 Oct 10;6(1):115.
    [参考文献]: Anna Lluveras-Tenorio, Et Al. The Development Of A New Analytical Model For The Identification Of Saccharide Binders In Paint Samples. Plos One. 2012;7(11):E49383.
    [参考文献]: Jin-Geun Choi, Et Al. Improvement In The Thermostability Of D-Psicose 3-Epimerase From Agrobacterium Tumefaciens By Random And Site-Directed Mutagenesis. Appl Environ Microbiol. 2011 Oct;77(20):7316-20.
    [参考文献]: Kayo Hasehira, Et Al. A Comprehensive Hplc Analytical System For The Identification And Quantification Of Hexoses That Employs 2-Aminobenzamide Coupling. J Biochem. 2010 Apr;147(4):501-9.

    合成参考文献


    摘要:S50 | CCSCOMPEND | The Unified Collision Cross Section (CCS) Compendium | DOI:10.5281/zenodo.2658162
    摘要:https://pubs.acs.org/doi/abs/10.1021/acs.analchem.8b04322
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