CAS: 637-39-8; Triethanolamine Hydrochloride

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CAS号541-41-3 氯甲酸乙酯 | CAS号102-71-6 三乙醇胺 | CAS号17422-32-1 5-氯吲哚 | CAS号358-21-4 PERFLUORODIETHY... | CAS号382-28-5 全氟(N-甲基吗啉) | CAS号110-91-8 吗啉 | CAS号109-01-3 N-甲基哌嗪 | CAS号622-40-2 N-(2-羟乙基)吗啉 | CAS号1723-94-0 4,4’-(1,2-乙亚基)双吗啉 | CAS号6425-39-4 双(2-吗啉二乙基)醚(DMDEE)

三乙醇胺置于mercury Dichloride体系中,用 乙醇 作为反应溶剂,化学反应 6.0H,以5%的收率获得产物三乙醇胺盐酸盐
参考文献:Structural Study Of The Coordination Behavior Of A Tetradentate No3-Donor Amino Alcohol Ligand Toward A Cdii:Hgii Mixture
标题:Structural Study Of The Coordination Behavior Of A Tetradentate No3-Donor Amino Alcohol Ligand Toward A Cdii:Hgii Mixture
摘要:本文研究了2,2',2''-硝基三乙醇(Nte)与cdi2和hgi2的1:1混合物的反应.合成并鉴定了复合物[cd(Nte)2][hg2(μ-I)2I4],并通过元素分析,Ft-Ir,1H NMR光谱和单晶x射线衍射确定了其结构.还介绍了[hnte]Cl盐的结构.在复合物的晶体结构中,镉原子具有cdn2O6的环境,呈略微扭曲的立方体几何形状.这种几何形状是镉配合物cambridge结构数据库中罕见的最小扭曲之一.阴离子部分具有双核结构,其中汞原子处于四面体环境中.在复合物的网络中,除了o−h . . . I氢键外,还有i . . . I相互作用,导致了十元环.
DOI:10.1515/znb-2016-0222

专利信息

专利号:US-2007015260-A1
优先权日:2002-03-14
标 题:Synthesis of synthons for the manufacture of bioactive compounds
发明人：WONG CHI-HUEY; LIU JUNJIE; DESANTIS GRACE; BURK MARK
权利人:SCRIPPS RESEARCH INST
摘要:The present invention is based on the discovery that 2-deoxyribose-5-phosphate aldolase (DERA, EC 4.1.2.4) and variants thereof can be used to catalyze sequential asymmetric aldol reactions between a wide variety of donor and acceptor aldehydes. The reaction products typically contain at least two new stereogenic centers and can be produced in enantiomerically pure form. As such, DERA catalyzed asymmetric aldol chemistry can be exploited to produce synthons for the synthesis of a variety of bioactive molecules.

专利号:US-12037623-B2
优先权日:2018-07-09
标 题 :Enzymatic synthesis of 4′-ethynyl nucleoside analogs
发明人：HUFFMAN MARK A; FRYSZKOWSKA ANNA; KOLEV JOSHUA N; DEVINE PAUL N; CAMPOS KEVIN R; TRUPPO MATTHEW; NAWRAT CHRISTOPHER C
权利人:MERCK SHARP & DOHME; MERCK SHARP & DOHME LLC
摘要:The present invention relates to an enzymatic synthesis of 4′-ethynyl-2′-deoxy nucleosides and analogs thereof, for example EFdA, that eliminates the use of protecting groups on the intermediates, improves the stereoselectivity of glycosylation and reduces the number of process steps needed to make said compounds. It also relates to the novel intermediates employed in the process.

专利号:US-7576234-B2
优先权日:2002-05-15
标题 :Synthesis of 2-alkyl amino acids
发明人：CHORGHADE MUKUND S; GURJAR MUKUND K; MOHAPATRA DEBENDRA K
权利人:GENZYME CORP
摘要:Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves a Michael-type addition of a nucleophile to a dialkyl 2-methylidenylpropan-1,3-dioate and the conversion of a ester moiety into an amino moiety. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, an aryl nitrile or imidate is condensed with cysteine, a 2-alkyl cysteine, or a cysteine ester.

专利号:US-9777022-B2
优先权日:2012-10-02
标题 :Process for the preparation of macrocyclic polyazacarboxylate ligands and chelates
发明人：MOORE DENNIS A; RAJAGOPALAN RAGHAVAN
权利人:MALLINCKRODT LLC; GUERBET SA
摘要:The present disclosure relates generally to a process for the synthesis of 1,4,7,10-tetraazacyclododecane ligands, chelates, and derivatives thereof. In particular, the present disclosure is directed to a process for the synthesis of 1,4,7,10-tetraaza-1,4,7,10-tetrakis(carboxymethyl)cyclododecane (DOTA) ligands, corresponding DOTA-metal chelates, and various derivatives thereof.

专利号:US-2024262834-A1
优先权日:2021-05-28
标 题:Synthesis of btk inhibitor and intermediates thereof
发明人：CHEN YONGGANG; CORRY JAMES; DESMOND RICHARD; DI MASO MICHAEL J; FORSTATER JACOB H; KUETHE JEFFREY T; KUHL NADINE; LARSON REED; LEVESQUE FRANCOIS; NARSIMHAN KARTHIK; OTTE DOUGLAS; PRIER CHRISTOPHER K; SHEVLIN MICHAEL; SIROTA ERIC; TAN LUSHI; THAISRIVONGS DAVID A; TURNBULL BEN W H; WANG ZHIXUN; XIAO KAIJIONG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient synthetic processes useful in the preparation of Compound A, a BTK inhibitor of Formula (I): or a pharmaceutically acceptable salt thereof, including the preparation of intermediates used to make Compound A or a pharmaceutically acceptable salt thereof.

专利号:US-4216171-A
优先权日:1977-11-21
标题:Novel compositions having a base of aminoalkoxy amines
发明人：LE LUDEC JOEL; SOULA GERARD
权利人:RHONE POULENC IND
摘要:Compositions containing at least one aminoalkoxy amine of the formula: (I) in which x is a whole number of from 1 to 3, are provided. They are prepared by cyanoethylation of tris(5-hydroxy-3-oxa-pentyl)amine with acrylonitrile followed by hydrogenation. They are useful as manufacturing intermediates, additives for lubricating oils, and in the synthesis of polyurethanes.