专利号:US-7601318-B2 优先权日:2000-09-26 标 题:Method for synthesis of carbon-coated redox materials with controlled size 发明人:ARMAND MICHEL; GAUTHIER MICHEL; MAGNAN JEAN-FRANCOIS; RAVET NATHALIE 权利人:HYDRO QUEBEC; CENTRE NAT RECH SCIENT; UNIV MONTREAL 摘要:A method for the synthesis of compounds of the formula C—Li x M 1−y M′ y (XO 4 ) n , where C represents carbon cross-linked with the compound Li x M 1−y M′ y (XO 4 ) n , in which x, y and n are numbers such as 0≦x≦2, 0≦y≦0.6, and 1≦n≦1.5, M is a transition metal or a mixture of transition metals from the first period of the periodic table, M′ is an element with fixed valency selected among Mg 2+ , Ca 2+ , Al 3+ , Zn 2+ or a combination of these same elements and X is chosen among S, P and Si, by bringing into equilibrium, in the required proportions, the mixture of precursors, with a gaseous atmosphere, the synthesis taking place by reaction and bringing into equilibrium, in the required proportions, the mixture of the precursors, the procedure comprising at least one pyrolysis step of the carbon source compound in such a way as to obtain a compound in which the electronic conductivity measured on a sample of powder compressed at a pressure of 3750 Kg·cm −2 is greater than 10 −8 S·cm −1 . The materials obtained have excellent electrical conductivity, as well a very improved chemical activity.
专利号:US-10266565-B2 优先权日:2011-04-12 标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use 发明人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN 权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES 摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.
专利号:US-2020262714-A1 优先权日:2017-09-14 标题:Synthesis of Lithium Titanate 发明人:REED CHRISTOPHER JOHN 权利人:Neomaterials Pty Ltd 摘要:A method for the synthesis of lithium titanate, the method comprising the method steps of: (i) reacting a source of titanium ions with a source of lithium ions at increased temperature in one or more reaction vessels for a period of time; and (ii) calcining the product of step (i) to produce a lithium titanate product having a nano-tube type crystal structure. An electrode material produced by the method of the invention and a lithium ion battery utilising the electrode material are also disclosed.
专利号:US-2025192223-A1 优先权日:2022-03-07 标 题:Synthesis of al-doped llzo thin-tape electrolytes for solid-state batteries using flame-assisted spray pyrolysis 发明人:DENG SILI; MULDOON VALERIE L; ZHANG JIANAN 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:A method of synthesis of aluminum-doped Li 6.25 Al 0.25 La 3 Zr 2 O 12 (Al-LLZO) can include preparing a precursor solution by dissolving lithium nitrate, aluminum nitrate, zirconium (IV) oxynitrate, and lanthanum nitrate in stoichiometric amounts according to the composition Li 6.25 Al 0.25 La 3 Zr 2 O 12 in water, and decomposing droplets by passing through a co-flow burner. Also disclosed is a method of produce producing a thin-tape comprising Al-LLZO.
专利号:US-2008317875-A1 优先权日:2006-07-10 标题 :Inhibitor of PI3 kinase-dependent inflammatory cytokine synthesis and method for inhibiting the same 发明人:KOYASU SHIGEO; OHTANI MASASHI; SASAKAW CHIHIRO; YOSHIDA SEI 权利人:KOYASU SHIGEO; OHTANI MASASHI; SASAKAW CHIHIRO; YOSHIDA SEI 摘要:The present invention provides a novel inhibitor for inhibiting synthesis of a PI3 kinase-dependent inflammatory cytokine in vivo in a vertebrate and a method for inhibiting the same. More particularly, the present invention provides a suppressor for suppressing a cell-mediated immune response and a method for suppressing the same, as well as an activator for activating a humoral immune response and a method for activating the same. In the present invention, by administering Li ion to a living body to inhibit synthesis of an inflammatory cytokine, a cell-mediated immune responses can be suppressed, and immune-mediated inflammatory disorders (IMIDs) can be treated.
专利号:US-5874632-A 优先权日:1996-05-15 标 题 :Method of producing ketoisophorone 发明人:HAHN RAINER; GORA ULRICH; HUTHMACHER KLAUS; HUEBNER FRANK; KRILL STEFFEN 权利人:DEGUSSA 摘要:An improved method of producing 3,5,5-trimethylcyclohex-2-ene-1,4-dione (KIP) by the oxidation of 3,5,5-trimethylcyclohex-3-ene-1-one ( beta -IP) in the presence of managansalene-like catalysts and certain catalytic additives. Byproducts:uct in the synthesis of trimethylhydroquinone, an initial substance in the synthesis of vitamin E. Furthermore, KIP is an initial compound for the synthesis of various carotinoids.
[参考文献]: Artur T Cordeiro, Et Al. Crystallization And Preliminary X-Ray Diffraction Analysis Of Leishmania Major Dihydroorotate Dehydrogenase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Oct 1;62(Pt 10):1049-51. [参考文献]: Benedikt Habermeyer, Et Al. [参考文献]: Psychiatr Prax. 2008 May;35(4):198-200. [参考文献]: Janaína Teles De Faria, Et Al. Use Of Response Surface Methodology To Evaluate The Extraction Of Debaryomyces Hansenii Xylose Reductase By Aqueous Two-Phase System. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877(27):3031-7. [参考文献]: Mareike Hütten, Et Al. In Vitro And In Vivo Evaluation Of A Hydrogel Reservoir As A Continuous Drug Delivery System For Inner Ear Treatment. Plos One. 2014 Aug 8;9(8):E104564. [参考文献]: Peter Zill, Et Al. Analysis Of Polymorphisms In The Alpha-Subunit Of The Olfactory G-Protein Golf In Lithium-Treated Bipolar Patients. Psychiatr Genet. 2003 Jun;13(2):65-9.
合成参考文献
摘要:EHP, Environmental Health Perspectives., 106(Suppl 参考文献:10.1038/srep05046 摘要:Zhu Y, Zhu LN, Guo R, Cui HJ, Ye S, Fang Q. Nanoliter-scale protein crystallization and screening with a microfluidic droplet robot. Sci Rep. 2014 May 23;4():5046. 参考文献:10.1038/ncomms4943 摘要:Yao H, Zheng G, Hsu PC, Kong D, Cha JJ, Li W, Seh ZW, McDowell MT, Yan K, Liang Z, Narasimhan VK, Cui Y. Improving lithium-sulphur batteries through spatial control of sulphur species deposition on a hybrid electrode surface. Nat Commun. 2014 May 27;5():3943. doi: 10.1038/ncomms4943. 参考文献:10.1038/ncomms14388 摘要:Nadal M, Prekovic S, Gallastegui N, Helsen C, Abella M, Zielinska K, Gay M, Vilaseca M, Taulès M, Houtsmuller AB, van Royen ME, Claessens F, Fuentes-Prior P, Estébanez-Perpiñá E. Structure of the homodimeric androgen receptor ligand-binding domain. Nature Communications. 2017 Feb 06;8(1):14388. doi: 10.1038/ncomms14388. 参考文献:10.1038/srep42123 摘要:Goto-Ito S, Yamagata A, Takahashi TS, Sato Y, Fukai S. Structural basis of the interaction between Topoisomerase IIIβ and the TDRD3 auxiliary factor. Scientific Reports. 2017 Feb 08;7(1):42123. doi: 10.1038/srep42123.