CAS: 108-10-1; 4-Methyl-2-Pentanone

上下游产品

CAS号108-11-2 甲基异丁基甲醇(MIBC) | CAS号105-44-2 4-甲基-2-戊酮肟 | CAS号67-64-1 丙酮 | CAS号67-63-0 异丙醇 | CAS号141-79-7 异丙叉丙酮 | CAS号123-72-8 正丁醛 | CAS号5660-53-7 1, 3-Dioxolane-... | CAS号503-74-2 异戊酸 | CAS号64-19-7 冰醋酸 | CAS号2035-08-7 2-methyl-2-(2-m... | CAS号10595-60-5 N,N'-bis(1,3-di... | CAS号1119-29-5 Pentanamide, 4-... | CAS号1112-78-3 2,2-dimethoxy-4... | CAS号105-51-1 2-Pentanamine,N... | CAS号40836-01-9 氯化2,4,6-三苯基吡喃嗡 | CAS号34036-16-3 5-甲基-3-羰基己酸乙酯 | CAS号57808-66-9 多潘立酮 | CAS号103-82-2 苯乙酸

4-甲基-2-戊醇置于iron(III) Chloride Hexahydrate,氧气,Silica Gel,2,2,6,6-四甲基哌啶氧化物体系中,用 甲苯 用作溶剂,80.0 °C,500.01 Kpa 条件下,反应 90.08H,以90%的收率获得4-甲基-2-戊酮
参考文献:硅胶存在下六水合氯化铁/ Tempo催化的醇的选择性好氧氧化
标题:硅胶存在下六水合氯化铁/ Tempo催化的醇的选择性好氧氧化
摘要:在硅胶存在下,使用分子印迹技术完成了fecl 3 •6H 2 O / 2,2,6,6-四甲基哌啶n-氧基(tempo)催化的醇氧化为相应的醛和酮的环保,高效过程氧气或空气作为终端氧化剂.缺电子的苯甲醇被平滑氧化为相应的醛,分离产率高达99%.发现硅胶不仅可以提高催化反应速率,而且可以提高产物的选择性.Fecl 3 •6H 2的高性能硅胶存在下的o / Tempo催化剂体系可能归因于表面硅烷醇基团.紫外可见光谱分析表明,Fe(III)-Tempo配合物可作为本催化体系中的活性中间物质.提出了催化系统的合理机理.版权所有©2012 John Wiley&sons,Ltd.
Doi:10.1002/aoc.1862

专利信息

专利号:WO-2025104067-A1
优先权日:2023-11-14
标题 :Use of a heterogeneous copper/zinc catalyst for continuous, gas-phase synthesis of methyl isobutyl ketone and/or methyl isobutyl carbinol by hydrogenation of mesityl oxide
发明人：RUPPIN CHRISTOPHE
权利人:ARKEMA FRANCE
摘要:The present invention relates to the use of a catalyst comprising a mixture of copper and zinc for continuous, gas-phase synthesis of methyl isobutyl ketone (MIBK) and/or methyl isobutyl carbinol (MIBC) from mesityl oxide. The invention also relates to a synthesis method comprising the following sequence of steps: continuous injection of the reagents in gas form through a reactor; hydrogenation reaction under pressure of hydrogen and at a temperature of between 120 and 250°C in the presence of the catalyst; condensation of the stream from the reactor and separation of the gas stream from the liquid stream; and purification of the liquid stream in order to separate the methyl isobutyl ketone and/or the methyl isobutyl carbinol.

专利号:US-9518047-B2
优先权日:2013-10-17
标题 :Process for the industrial synthesis of lurasidone
发明人：ANGELINI TOMMASO; BETTONI PIERGIORGIO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:Disclosed is a process for the industrial synthesis of Lurasidone from (1R,2R)-cyclohexane-1,2-diyldimethanol (1), 3-(piperazin-1-yl)benzo[d]isothiazole (3) and (3aR,4R,7R,7aS)-3a,4,7,7a-tetrahydro-4,7-methanoisobenzofuran-1,3-dione (6).). Said process is optimised to obtain Lurasidone with high yields and high purities by preparing highly pure synthesis intermediates, using critical raw materials and reagents in amounts close to the stoichiometric amounts, increasing productivity and reducing the costs and environmental impact of the process.

专利号:US-2024247022-A1
优先权日:2021-05-04
标 题 :A Process for Synthesis of Nicotinamide Riboside Chloride (NRCL)
发明人：MALKANNAGARI RAMANI; GUNDAPUNENI RAGHAVA RAO; BOHAN FRODE
权利人:BOHAN & CO AS
摘要:The present invention discloses synthesis of nicotinamide riboside chloride (NRCI). More particularly, the present invention describes cost effective and industrially scalable process for the synthesis of NRCI in amorphous form.

专利号:US-8791287-B2
优先权日:2010-07-02
标 题:Process for the synthesis of tapentadol and intermediates thereof
发明人：MOTTA GIUSEPPE; VERGANI DOMENICO; BERTOLINI GIORGIO; LANDONI NICOLA
权利人:MOTTA GIUSEPPE; VERGANI DOMENICO; BERTOLINI GIORGIO; LANDONI NICOLA; EUTICALS SPA
摘要:The object of the present invention is a new process for the synthesis of tapentadol, both as free base and in hydrochloride form, which comprises the step of alkylation of the ketone (VII) to yield the compound (VIII), as reported in Diagram 1, with high stereoselectivity due to the presence of the benzyl group as substituent of the amino group. It was surprisingly found that this substitution shifts the keto-enol equilibrium towards the desired enantiomer and amplifies the capacity of the stereocenter present in the compound (VII) to orient the nucleophilic addition of the organometallic compound at the carbonyl towards the desired stereoisomer. This substitution thus allows obtaining a considerable increase of the yields in this step, and consequently allows significantly increasing the overall yield of the entire tapentadol synthesis process. n A further object of the present invention is constituted by the tapentadol free base in solid form, obtainable by means of the process of the invention. n Still another object of the invention is represented by the crystalline forms I and II of the tapentadol free base. n A further object of the present invention is the mixture of the crystalline forms I and II of the tapentadol free base.

专利号:US-2023287032-A1
优先权日:2020-08-14
标 题:Synthesis of fluorinated nucleotides
发明人：CHUNG CHEOL KEUN; LIU ZHIJIAN; MALIGRES PETER E; MAO EDNA; OBLIGACION JENNIFER V; PHILLIPS ERIC M; PIRNOT MICHAEL; POIRIER MARC; SONG ZHIGUO JAKE; WANG TAO
权利人:CHUNG CHEOL KEUN; LIU ZHIJIAN; MALIGRES PETER E; MAO EDNA; OBLIGACION JENNIFER V; PHILLIPS ERIC M; PIRNOT MICHAEL; POIRIER MARC; SONG ZHIGUO JAKE; WANG TAO; MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (O—{[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl}O,O-dihydrogen phosphorothioate, also known as 2′-(S)-fluoro-thio-adenosine monophosphate or 2′-F-thio-AMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

专利号:US-7294743-B2
优先权日:2003-10-23
标题:Method for synthesis of acrylamide derivatives
发明人：ALGOTSSON MATTIAS; BUSSON PHILIPPE; THEVENIN NICOLAS
权利人:GE HEALTHCARE BIO SCIENCES AB
摘要:The present invention relates to a method for synthesis of an acrylamide derivative, starting with dissolving a salt of a nucleophilic amine in water to form an aqueous solution and desalting said solution with a base, comprising the following steps:n a) addition of dissolved activated acrylic acid derivative to said solution; b) acidification of aqueous phase; and c) extraction of said aqueous phase.