CAS: 142569-70-8; (S)-1-(3-(2-(7-Chloroquinolin-2-yl)Vinyl)Phenyl)-3-(2-(2-Hydroxypropan-2-yl)Phenyl)Propan-1-Ol

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CAS号158966-92-8 孟鲁司特 | CAS号151767-02-1 孟鲁司特钠

2-[3-(R)-[3-[2-(7-氯-2-喹啉基)乙烯基]苯基]-3-羰基丙基]苯甲酸甲酯置于n,N-二异丙基乙胺体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 15.83H,反应生成2-(2-(3-(2-(7-氯-2-喹啉基)-乙烯基苯基)-3-羟基丙基)苯基)-2-丙醇
参考文献:Cn115710221
标题:Cn115710221

专利信息

专利号:EP-2178841-B1
优先权日:2007-07-13
标题:Process and intermediate for the production of a tertiary alcohol as an intermediate in the synthesis of montelukast
发明人：MCGARRITY JOHN; DJOJO FRANCIS
权利人:LONZA AG
摘要:The tertiary alcohol ±-[3-[(1 E )2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methylethyl)benzenepropanol, the (± S )-enantioner of which is an intermediate in the production of montelukast, is produced by reacting the novel lactone of formula nwith a methylmagnesium halide in an ethereal solvent in the presence of lanthanum trichloride and lithium chloride. The lactone II can be prepared by reacting a corresponding hydroxycster with a Grignard reagent in the absence of a lanthanoid compound.

专利号:US-2010190987-A1
优先权日:2007-07-13
标题 :Process and intermediate for the production of a tertiary alcohol as an intermediate in the synthesis of montelukast