CAS: 16068-46-5; Phosphoric Acid, Xpotassium Salt

专利信息

专利号:WO-2020215726-A1
优先权日:2019-04-26
标题:Recycling process of waste generated in synthesis of thioacetic acid
发明人：ZHANG SHIJIN; ZHANG XIANGZHOU; LIU DUNSHENG; MA ZHAOFENG
权利人:TENGZHOU TIANSHUI BIO TECH CO LTD
摘要:A recycling process of waste generated in synthesis of thioacetic acid, comprising: in a thioacetic acid synthesis process, pretreating a thioacetic acid synthesis reaction solution, transferring the reaction solution to a filter device, separating a solid phase from a liquid phase in the reaction solution, and separating waste from the reaction solution in advance; and treating the separated solid phase: washing the solid phase, and performing separation after the washing; feeding the washed solid phase into a drier for drying, separating the dried solid, and condensing the liquid phase; adding the dried solid into a dissolving kettle, adding water into the kettle, stirring and heating to micro-boiling and reflux, so that the dried solid is fully dissolved; then adding a potassium hydroxide solution into the solution for neutralization, during which boiling should be prevented and which lasts for not shorter than 5 min; filtering a neutralization solution, and separating solid precipitate therefrom; neutralizing a filtrate obtained after the filtration to perform evaporative concentration, and primarily separating water from monopotassium phosphate; performing a further separation operation on a monopotassium phosphate concentrated solution, the solid obtained after the separation being a monopotassium phosphate product; and repeating the previous step for re-concentration.

专利号:US-12281348-B2
优先权日:2020-11-08
标 题:Method for the continuous flow synthesis of (R)-4-halo-3-hydroxy-butyrate
发明人：CHEN FENER; CHENG DANG; HUANG ZEDU; LIU MINJIE; HUANG HUASHAN; JIANG MEIFEN; WANG LULU
权利人:UNIV FUDAN
摘要:This application relates to organic synthesis, and more particularly to a method for the continuous flow synthesis of (R)-4-halo-3-hydroxy-butyrate using a micro-reaction system. This application performs an enzymatic asymmetric reduction of a substrate solution containing halogenated acetoacetate and a biocatalyst solution in the micro-reaction system composed of a micro-mixer, a micro-channel reactor, and a pH regulator to obtain the (R)-4-halo-3-hydroxy-butyrate. Compared to the prior art, the reaction time of the method is only a few minutes, the yield of the product (R)-4-halo-3-hydroxy-butyrate is greater than 95%, the reaction process is continuous, the degree of automation is high, the efficiency is high, and the process is simple to operate and easy to be used in industrialized production.

专利号:US-11198862-B2
优先权日:2018-04-04
标 题 :Method for promoting acetylglucosamine synthesis of bacillus subtilis
发明人：LIU LONG; GU YANG; DENG JIEYING; CHEN JIAN; DU GUOCHENG; LI JIANGHUA
权利人:UNIV JIANGNAN
摘要:The present invention relates to a method for promoting acetylglucosamine synthesis of Bacillus subtilis, which belongs to the field of genetic engineering. The present invention adopts the recombinant Bacillus subtilis BSGNKAP2 as a starting strain, exogenously introducing pyruvate carboxylase BalpycA derived from Bacillus cereus, eliminating the central carbon metabolism overflow of the Bacillus subtilis and avoiding the synthesis of the by-product acetoin; further, five exogenous reducing force metabolic reactions are introduced to replace the reaction of generating NADH in glycolysis pathway and tricarboxylic acid cycle to reconstruct intracellular reducing force metabolism, which specifically comprise glyceraldehyde-3-phosphate ferredoxin dehydrogenase, isocitrate NAD+ dehydrogenase, a malate quinone dehydrogenase, a ketoacid ferredoxin oxidoreductase and a nitrogenase ferritin. In a shake-flask fermentation process using a complex medium, acetylglucosamine yield of the recombinant strain BSGNKAP8 is 24.50 g/L, acetylglucosamine/glucose yield is 0.469 g/g, respectively 1.97 times and 2.13 times of those of the starting strain BSGNKAP2.

专利号:US-5057624-A
优先权日:1989-03-31
标 题 :Process for the synthesis of the n-methyl-3,4-dimethoxyphenylethylamine
发明人：CANNATA VINCENZO; TAMERLANI GIANCARLO; ZAGNONI GRAZIANO
权利人:ALFA WASSERMANN SPA
摘要:New process for the synthesis of the N-methyl-3,4-dimetoxyphenylethylamine of formula ##STR1## intermediate in the synthesis of the drug internationally known as verapamil. The process starts from the 3,4-dimethoxybenzaldehyde which, by means of a Darzens condensation, gives an epoxyester that, by alkaline hydrolysis and subsequent decarboxylation, gives the 3,4-dimethoxyphenylacetaldehyde. This aldehyde gives the amine of formula I by reaction with monomethylamine followed by reduction with sodium borohydride.

专利号:US-6825378-B2
优先权日:2003-03-28
标 题 :Process for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid
发明人：KUMAR PRADEEP; FERNANDES RODNEY AGUSTINHO; GUPTA PRITI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention provides a process for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid of formula (1). The present invention more particularly relates to a process using cyclohexylphenyl ketone for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid of formula (1).

专利号:US-2023174567-A1
优先权日:2020-05-22
标题:Synthesis of fluorinated nucleotides
发明人：ARMIGER TRAVIS; BELYK KEVIN M; BENKOVICS TAMAS; CHUNG CHEOL K; JI CHEN YINING; JOHNSON HEATHER CLAIRE; KLAPARS ARTIS; LIU ZHIJIAN; LIU ZHUQING; MOORE JEFFREY C; NEEL ANDREW J; PENG FENG; RUMMELT STEPHAN M; SALEHI MARZUARANI NASTARAN; SHERRY BENJAMIN D; SONG ZHIGUO JAKE; TURNBULL BEN WILLIAM HULME; WANG LU; XU FENG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3′-fluoro-thio-guanosine monophosphate or 3′-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. (I)