CAS: 60230-36-6; 2,6-Difluorobenzene-1-Sulfonyl Chloride

上下游产品

CAS号372-18-9 1,3-二氟苯 | CAS号60230-37-7 2,6-二氟苯磺酰胺 | CAS号1195765-45-7 达拉菲尼 | CAS号1195768-06-9 达帕菲尼甲磺酸盐

1,3-二氟苯置于正丁基锂,二氧化硫,N-氯代丁二酰亚胺体系中,用 乙醚,正己烷 作为反应溶剂,化学反应 4.33H,反应生成 2,6-二氟苯磺酰氯
参考文献:Deuterated Benzene Sulfonamide Thiazole Compounds
标题:Deuterated Benzene Sulfonamide Thiazole Compounds
摘要:含有n-{3-[5-(2-氨基-4-嘧啶基)-2-(1,1-二甲基乙基)-1,3-噻唑-4-基]-2-氟苯基}-2,6-二氟苯磺酰胺的氘代形式及含有该化合物的药物组合物.

专利信息

专利号:US-10039844-B2
优先权日:2014-12-03
标 题 :Imaging tumor glycolysis by non-invasive measurement of pyruvate kinase M2
发明人：WITNEY TIMOTHY; JAMES MICHELLE L; GAMBHIR SANJIV S
权利人:UNIV LELAND STANFORD JUNIOR
摘要:A novel pyruvate kinase M2 (PKM2)-specific activator, [ 11 C]DASA-23 and derivatives thereof, and methods for their rapid synthesis are provided. The probes are particularly useful in methods for the non-invasive positron emission tomography (PET) detection and imaging of PKM2 expression in subcutaneous and orthotopic tumors. [ 11 C]DASA-23 cell uptake correlates with PKM2 protein expression in cultured tumor cells and orthotopic tumors are delineated from the surrounding normal brain tissue in vivo.

专利号:CN-117720498-A
优先权日:2023-11-03
标 题 :Synthesis of a new coumarin derivative containing a sulfonamide fragment and preparation method and application of its composition

专利号:US-8163773-B2
优先权日:2005-07-11
标题 :Organic compounds
发明人：BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI
权利人:BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI; NOVARTIS AG
摘要:The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The preferred compounds (which can also be present as salts) have the formula I wherein R1, R2, T, R3 and R4 are as defined in the specification.