CAS: 80-40-0; Ethyl 4-Methylbenzenesulfonate

相似化合物

6165-76-0 4873-09-0 515-46-8

上下游产品

CAS号25566-59-0 N-methyl-N-(2-p... | CAS号64-17-5 乙醇 | CAS号104-15-4 对甲苯磺酸 | CAS号98-59-9 对甲苯磺酰氯(PTSC) | CAS号68-34-8 对甲苯磺酰苯胺 | CAS号109-63-7 三氟化硼乙醚 | CAS号1825-62-3 三甲基乙氧基硅烷 | CAS号75717-32-7 5-methyl-4-(phe... | CAS号4819-83-4 2H-Pyran, 2-eth... | CAS号5331-73-7 Ethyl 3-ethoxy-... | CAS号57592-45-7 3-乙氧基-2-丁烯酸乙酯 | CAS号1619-57-4 2,2-二乙基乙酰乙酸乙酯 | CAS号607-97-6 2-乙基乙酰乙酸乙酯 | CAS号3289-28-9 环己甲酸乙酯 | CAS号104-15-4 对甲苯磺酸 | CAS号93-89-0 苯甲酸乙酯 | CAS号93-55-0 苯丙酮 | CAS号14933-76-7 3-乙基-2-甲基苯并唑对甲基苯磺酸酯 | CAS号94-68-8 N-乙基邻甲苯胺

Ethyl P-Toluenesulfinate置于potassium Permanganate,溶剂黄146体系中,化学反应生成 对甲苯磺酸乙酯
参考文献:Otto; Roessing,Chemische Berichte,1886,Vol. 19,P. 1226
标题:Otto; Roessing,Chemische Berichte,1886,Vol. 19,P. 1226

专利信息

专利号:US-9085518-B2
优先权日:2011-10-14
标题 :Method for the synthesis of 18F-labelled molecules
发明人：NAIRNE ROBERT JAMES DOMETT; BHALLA RAJIV; KHAN IMTIAZ; BROWN JANE; WILSON ANTHONY; BLACK ANDRES
权利人:GE HEALTHCARE LTD
摘要:The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, in a preferred embodiment, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimized.

专利号:US-6417380-B1
优先权日:1987-12-31
标 题 :Synthesis of 1,2-dioxetanes and intermediates therefor
发明人：BRONSTEIN IRENA Y; EDWARDS BROOKS
摘要:Compounds having the formula: n wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C 1-20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (e.g., n m-phenylene), produced by reacting a compound having the formula: n with an R-ylating agent (e.g., R 2 SO 4 ) in the presence of an alkali metal alkoxide in a polar aprotic solvent. Also, compounds having the formula: n are produced by reacting a compound having the formula: n with n wherein X is an electronegative leaving group (e.g., a halogen anion such as chloride ion) in the presence of a Lewis base (e.g., a trialkyl-amine) dissolved in an aprotic organic solvent (e.g., benzene or toluene). Also, compounds having the formula n are produced by reacting a compound of the formula n with a tetra-O-acylated-O-hexopyranoside halide, then hydrolyzing off the protective acyl groups. The aforementioned compounds and procedures are useful in the synthesis of enzyme-cleavable 1,2-dioxetane ring systems that can serve as members of a binding pair employed, for example, in chemiluminescent immunoassays, DNA probe assays, and direct assays for an enzyme.

专利号:US-4237054-A
优先权日:1979-05-18
标 题 :Total synthesis of (1RS,4SR,5RS)-4-(4,8-dimethyl-5-hydroxy-7-nonenyl)-4-methyl-3,8-dioxabicyclo[3.2.1] octane-1-acetic acid
发明人：CHEN ROBERT H K
权利人:ORTHO PHARMA CORP
摘要:A method for the total synthesis of (1RS,4SR,5RS)-4-(4,8-dimethyl-5-hydroxy-7-nonenyl)-4-methyl-3,8-dioxabicyclo [3.2.1] octane-1-acetic acid is described. The compound is active as a utero-evacuant agent.

专利号:US-9125954-B2
优先权日:2011-10-14
标 题 :Method for the synthesis of 18F-labelled biomolecules
发明人：BHALLA RAJIV; WILSON ANTHONY; KHAN IMTIAZ; BROWN JANNE
权利人:GE HEALTHCARE LTD
摘要:The present invention provides a method for the synthesis of 18 F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimized.

专利号:US-5777133-A
优先权日:1987-12-31
标 题:Synthesis of 1, 2-dioxetanes and intermediates therefor
发明人：BRONSTEIN IRENA Y; EDWARDS BROOKS
权利人:TROPIX INC
摘要:Compounds having the formula: ##STR1## wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C 1-20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (eg., m-phenylene), produced by reacting a compound having the formula: ##STR2## with an R-ylating agent (e.g., R 2 SO 4 ) in the presence of an alkali metal alkoxide in a polar aprotic solvent. Also, compounds having the formula: ##STR3## are produced by reacting a compound having the formula: ##STR4## wherein X is an electronegative leaving group (e.g., a halogen anion such as chloride ion) in the presence of a Lewis base (e.g., a trialkyl-amine) dissolved in an aprotic organic solvent (e.g., benzene or toluene). Also, compounds having the formula ##STR5## are produced by reacting a compound of the formula ##STR6## with a tetra-O-acylated-O-hexopyranoside halide, then hydrolyzing off the protective acyl groups. The aforementioned compounds and procedures are useful in the synthesis of enzyme-cleavable 1,2-dioxetane ring systems that can serve as members of a binding pair employed, for example, in chemiluminescent immunoassays, DNA probe assays, and direct assays for an enzyme.

专利号:US-4956477-A
优先权日:1987-12-31
标 题:Synthesis of 1,2-dioxetanes
发明人：BRONSTEIN IRENA Y; EDWARDS BROOKS
权利人:TROPIX INC
摘要:Compounds having the formula: ##STR1## wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C 1-20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (e.g., m-phenylene), produced by reacting a compound having the formula: ##STR2## with an R-ylating agent (e.g., R 2 SO 4 ) in the presence of an alkali metal alkoxide in a polar aprotic solvent. Also, compounds having the formula: ##STR3## are produced by reacting a compound having the formula: ##STR4## wherein X is an electronegative leaving group (e.g., a halogen anion such as chloride ion) in the presence of a Lewis base (e.g., a trialkyl-amine) dissolved in an aprotic organic solvent (e.g., benzene or toluene). Also, compounds having the formula ##STR5## are produced by reacting a compound of the formula ##STR6## with a tetra-O-acylated-O-hexopyranoside halide, then hydrolyzing off the protective acyl groups. The aforementioned compounds and procedures are useful in the synthesis of enzyme-cleavable 1,2-dioxetane ring systems that can serve as members of a binding pair employed, for example, in chemiluminescent immunoassays, DNA probe assays, and direct assays for an enzyme.