专利号:US-7429670-B2 优先权日:2003-08-27 标题 :Synthesis of derivatives of ginkgolide C 发明人:NAKANISHI KOJI; JARACZ STANISLAV; STROMGAARD KRISTIAN 权利人:UNIV COLUMBIA 摘要:The subject invention provides ginkgolide C derivatives compounds having the structure: n n n n n n n n n n wherein R is H or -A-Ar,n where A is an alkyl group; and Ar is an aryl group, which may contain heteroatoms and may be unsubstituted or substituted by one to five substituents each selected from the group consisting of hydrogen, alkoxy, —CH 2 CO 2 R 4 , and —CH 2 CONR 5 R 6 ;n where R 4 is an alkyl group; and R 5 and R 6 are each, independently, hydrogen or a branched or unbranched alkyl group; n n n wherein R 1 is H or —COR 7 ,n where R 7 is alkyl, aryl or amino; n n wherein R 2 is present or absent, and when present is H, —COR 8 or —CO—Z—R 8 ;n where R 8 is alkyl, aryl or amino; and Z is oxygen; n n wherein R 3 is present or absent, and when present is —COR 9 ;n where R 9 is alkyl or aryl; n n wherein only one of R 2 or R 3 is present in the compound; n wherein only two of R, R 1 , R 2 and R 3 are H; and n wherein each of a and b designates a single covalent bond which is present or absent,n where bond a is present when R 3 is absent and bond b is present when R 2 is absent;n nor an optically pure enantiomer of the compound. Additionally, the subject invention provides methods of inhibiting the activity of a glycine receptor using these compounds.
专利号:WO-2019013789-A1 优先权日:2017-07-12 标 题 :ANTIMICROBIAL COMPOUNDS 发明人:REDDY HARIPRASADA R KANNA; SEBAHAR PAUL R; SERRANO CATHERINE M; LOOPER RYAN E 权利人:CURZA GLOBAL LLC; THE UNIV OF UTAH RESEARCH FOUNDATION 摘要:The invention relates to compounds of formula I or their pharmaceutically acceptable salts. The compounds of formula I are antimicrobial agents which inhibit, for example, Mycobacterium tuberculosis (Mtb) H37Ra. The compounds of formula I also have anti-tuberculous activity, exhibit limited cytotoxicity and inhibit protein synthesis. The invention also relates to methods of making compounds of formula I, as well as methods of using compounds of formula I for the treatment of bacterial infections, particularly tuberculosis.
专利号:US-2009221019-A1 优先权日:2005-06-22 标 题:Core-Modified Terpene Trilactones From Ginkgo Biloba Extract and Biological Evaluation Thereof 发明人:NAKANISHI KOJI; DZYUBA SERGEI; ISHII HIDEKI 权利人:NAKANISHI KOJI; DZYUBA SERGEI; ISHII HIDEKI 摘要:Lactone-rings of ginkgolides are converted into the corresponding tetrahydrofuran moieties via DIBAL-H reduction followed by deoxygenation of the formed lactols with Et 3 SiH/BF 3 Et 2 O producing a series of lactol-free ginkgolides. The present invention also relates to synthesis of hydroxyl-free, or hydroxyl-free and lactone-free, ginkgolides and bilobalides.
专利号:US-2005119336-A1 优先权日:2003-08-27 标 题:Synthesis of derivatives of ginkgolide C
专利号:CN-101365674-A 优先权日:2005-07-21 标题:Modulators of interleukin-1 and tumor necrosis factor alpha, synthesis of the modulators and methods of using the modulators
专利号:WO-2005021496-A2 优先权日:2003-08-27 标 题 :Synthesis of derivatives of ginkgolide c
参考标题:Cobalt(II)-Catalyzed Isocyanide Insertion Reaction With Sulfonyl Azides In Alcohols: Synthesis Of Sulfonyl Isoureas 作者:Tian Jiang,Zheng-Yang Gu,Ling Yin,Shun-Yi Wang,Shun-Jun Ji |发布日期:2017.8.4 摘要:A Co(II)-Catalyzed Isocyanide Insertion Reaction With Sulfonyl Azides In Alcohols To Form Sulfonyl Isoureas Via Nitrene Intermediate Has Been Developed. This Protocol Provides A New, Environmentally Friendly, And Simple Strategy For The Synthesis Of Sulfonyl Isourea Derivatives By Employing A Range Of Substrates Under Mild Conditions.
合成参考文献
参考文献:10.1007/978-3-642-52704-3_7 摘要:Shcherbakova, I., Science of Synthesis, (2007) 31, 813.